Incidencia del virus Herpes simplex en pacientes con infecciones agudas del sistema nervioso central
Abstract: Herpes simplex viruses are agents responsible for a variety of infections on buccal and genital mucosa; they are neurotropic, capable of lodging in the nerve cells and remaining latent with subsequent reactivations; in some cases, they can provoke meningitis and encephalitis; and they have...
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Universidad del Zulia,Facultad de Medicina,Departamento de Enfermedades Infecciosas y Tropicales
2010
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ftdoajarticles:oai:doaj.org/article:41f3fa1b88d847ff97d6aa8dba20096c 2023-10-01T03:54:21+02:00 Incidencia del virus Herpes simplex en pacientes con infecciones agudas del sistema nervioso central Pérez S Kriss Porto-Espinoza Leticia Mindiola Raimy Callejas M Diana Estévez Jesús Moronta, Reyna 2010-12-01T00:00:00Z https://doaj.org/article/41f3fa1b88d847ff97d6aa8dba20096c EN ES eng spa Universidad del Zulia,Facultad de Medicina,Departamento de Enfermedades Infecciosas y Tropicales https://drive.google.com/file/d/1Vx-kNDNn1HIjZimB7QmZq4KQFDi8RWX3/view https://doaj.org/toc/0075-5222 https://doaj.org/toc/2477-9628 0075-5222 2477-9628 https://doaj.org/article/41f3fa1b88d847ff97d6aa8dba20096c Kasmera, Vol 38, Iss 2, Pp 147-156 (2010) Herpesvirus meningitis encefalitis líquido cefalorraquídeo (lcr) suero anticuerpos Herpes viruses encephalitis cerebrospinal fluid antibodies Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2010 ftdoajarticles 2023-09-03T00:35:36Z Abstract: Herpes simplex viruses are agents responsible for a variety of infections on buccal and genital mucosa; they are neurotropic, capable of lodging in the nerve cells and remaining latent with subsequent reactivations; in some cases, they can provoke meningitis and encephalitis; and they have a significant morbidity and are associated with a high mortality. The present project aims to determine HSV’s effect on the etiology of acute central nervous system (CNS) syndromes using the detection of specific antibodies in serum and cerebrospinal fluid. The 93 paired samples from patients with neurological affectations studied demonstrated negative results in the LCR bacteriological study and their Alb-LCR/Alb-serum relation was < 0.0075. Antibodies were detected by the enzymatic immunoassay ELISA method, where 1.2% (1/93) of the serum samples turned out positive for IgM; 89.24% (83/93) of the serum samples resulted positive for IgG; and 27.39% (20/93) of LCR samples were positive for anti-IgG. IgG presence in LCR suggested the intrathecal production of these antibodies inside the CNS, which demonstrates a significant participation by this viral agent in infections and diseases associated with the CNS. Resumen: Los Virus Herpes Simple son responsables de una variedad de infecciones a nivel de mucosas bucal y genital, son neurotrópicos, capaces de alojarse en células nerviosas y permanecer latentes con subsecuentes reactivaciones, en algunos casos pueden provocar meningitis y encefalitis. tienen una morbilidad significativa y una mortalidad elevada. El presente estudio tiene como objetivo determinar la incidencia de VHS en la etiología de los síndromes agudos del SNC mediante la detección en suero y LCR de anticuerpos específicos. Se estudiaron 93 muestras pareadas de pacientes con afecciones neurológicas que mostraron resultados negativos en el estudio bacteriológico de LCR y cuya relación Alb-LCR/Alb-suero fue <0,0075. Los anticuerpos fueron detectados por el método de inmunoensayo enzimático Elisa: ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English Spanish |
topic |
Herpesvirus meningitis encefalitis líquido cefalorraquídeo (lcr) suero anticuerpos Herpes viruses encephalitis cerebrospinal fluid antibodies Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Herpesvirus meningitis encefalitis líquido cefalorraquídeo (lcr) suero anticuerpos Herpes viruses encephalitis cerebrospinal fluid antibodies Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Pérez S Kriss Porto-Espinoza Leticia Mindiola Raimy Callejas M Diana Estévez Jesús Moronta, Reyna Incidencia del virus Herpes simplex en pacientes con infecciones agudas del sistema nervioso central |
topic_facet |
Herpesvirus meningitis encefalitis líquido cefalorraquídeo (lcr) suero anticuerpos Herpes viruses encephalitis cerebrospinal fluid antibodies Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Abstract: Herpes simplex viruses are agents responsible for a variety of infections on buccal and genital mucosa; they are neurotropic, capable of lodging in the nerve cells and remaining latent with subsequent reactivations; in some cases, they can provoke meningitis and encephalitis; and they have a significant morbidity and are associated with a high mortality. The present project aims to determine HSV’s effect on the etiology of acute central nervous system (CNS) syndromes using the detection of specific antibodies in serum and cerebrospinal fluid. The 93 paired samples from patients with neurological affectations studied demonstrated negative results in the LCR bacteriological study and their Alb-LCR/Alb-serum relation was < 0.0075. Antibodies were detected by the enzymatic immunoassay ELISA method, where 1.2% (1/93) of the serum samples turned out positive for IgM; 89.24% (83/93) of the serum samples resulted positive for IgG; and 27.39% (20/93) of LCR samples were positive for anti-IgG. IgG presence in LCR suggested the intrathecal production of these antibodies inside the CNS, which demonstrates a significant participation by this viral agent in infections and diseases associated with the CNS. Resumen: Los Virus Herpes Simple son responsables de una variedad de infecciones a nivel de mucosas bucal y genital, son neurotrópicos, capaces de alojarse en células nerviosas y permanecer latentes con subsecuentes reactivaciones, en algunos casos pueden provocar meningitis y encefalitis. tienen una morbilidad significativa y una mortalidad elevada. El presente estudio tiene como objetivo determinar la incidencia de VHS en la etiología de los síndromes agudos del SNC mediante la detección en suero y LCR de anticuerpos específicos. Se estudiaron 93 muestras pareadas de pacientes con afecciones neurológicas que mostraron resultados negativos en el estudio bacteriológico de LCR y cuya relación Alb-LCR/Alb-suero fue <0,0075. Los anticuerpos fueron detectados por el método de inmunoensayo enzimático Elisa: ... |
format |
Article in Journal/Newspaper |
author |
Pérez S Kriss Porto-Espinoza Leticia Mindiola Raimy Callejas M Diana Estévez Jesús Moronta, Reyna |
author_facet |
Pérez S Kriss Porto-Espinoza Leticia Mindiola Raimy Callejas M Diana Estévez Jesús Moronta, Reyna |
author_sort |
Pérez S Kriss |
title |
Incidencia del virus Herpes simplex en pacientes con infecciones agudas del sistema nervioso central |
title_short |
Incidencia del virus Herpes simplex en pacientes con infecciones agudas del sistema nervioso central |
title_full |
Incidencia del virus Herpes simplex en pacientes con infecciones agudas del sistema nervioso central |
title_fullStr |
Incidencia del virus Herpes simplex en pacientes con infecciones agudas del sistema nervioso central |
title_full_unstemmed |
Incidencia del virus Herpes simplex en pacientes con infecciones agudas del sistema nervioso central |
title_sort |
incidencia del virus herpes simplex en pacientes con infecciones agudas del sistema nervioso central |
publisher |
Universidad del Zulia,Facultad de Medicina,Departamento de Enfermedades Infecciosas y Tropicales |
publishDate |
2010 |
url |
https://doaj.org/article/41f3fa1b88d847ff97d6aa8dba20096c |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Kasmera, Vol 38, Iss 2, Pp 147-156 (2010) |
op_relation |
https://drive.google.com/file/d/1Vx-kNDNn1HIjZimB7QmZq4KQFDi8RWX3/view https://doaj.org/toc/0075-5222 https://doaj.org/toc/2477-9628 0075-5222 2477-9628 https://doaj.org/article/41f3fa1b88d847ff97d6aa8dba20096c |
_version_ |
1778521884192669696 |