Effect of Gene and Physical Activity Interaction on Trunk Fat Percentage Among the Newfoundland Population
Objective To explore the effect of FTO gene and physical activity interaction on trunk fat percentage. Design and Methods Subjects are 3,004 individuals from Newfoundland and Labrador whose trunk fat percentage and physical activity were recorded, and who were genotyped for 11 single-nucleotide poly...
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ftdoajarticles:oai:doaj.org/article:4187651518a84b62a69d2d07889a969d 2023-05-15T17:21:33+02:00 Effect of Gene and Physical Activity Interaction on Trunk Fat Percentage Among the Newfoundland Population Anthony Payne Farrell Cahill Guang Sun J Concepción Loredo-Osti Taraneh Abarin 2014-01-01T00:00:00Z https://doi.org/10.4137/GEG.S14957 https://doaj.org/article/4187651518a84b62a69d2d07889a969d EN eng SAGE Publishing https://doi.org/10.4137/GEG.S14957 https://doaj.org/toc/1179-237X 1179-237X doi:10.4137/GEG.S14957 https://doaj.org/article/4187651518a84b62a69d2d07889a969d Genetics and Epigenetics, Vol 6 (2014) Genetics QH426-470 article 2014 ftdoajarticles https://doi.org/10.4137/GEG.S14957 2022-12-31T01:29:42Z Objective To explore the effect of FTO gene and physical activity interaction on trunk fat percentage. Design and Methods Subjects are 3,004 individuals from Newfoundland and Labrador whose trunk fat percentage and physical activity were recorded, and who were genotyped for 11 single-nucleotide polymorphisms (SNPs) in the FTO gene. Subjects were stratified by gender. Multiple tests and multiple regressions were used to analyze the effects of physical activity, variants of FTO , age, and their interactions on trunk fat percentage. Dietary information and other environmental factors were not considered. Results Higher levels of physical activity tend to reduce trunk fat percentage in all individuals. Furthermore, in males, rs9939609 and rs1421085 were significant (α = 0.05) in explaining central body fat, but no SNPs were significant in females. For highly active males, trunk fat percentage varied significantly between variants of rs9939609 and rs1421085, but there is no significant effect among individuals with low activity. The other SNPs examined were not significant in explaining trunk fat percentage. Conclusions Homozygous male carriers of non-obesity risk alleles at rs9939609 and rs1421085 will have significant reduction in central body fat from physical activity in contrast to homozygous males of the obesity-risk alleles. The additive effect of these SNPs is found in males with high physical activity only. Article in Journal/Newspaper Newfoundland Directory of Open Access Journals: DOAJ Articles Newfoundland Genetics & Epigenetics 6 GEG.S14957 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Genetics QH426-470 |
spellingShingle |
Genetics QH426-470 Anthony Payne Farrell Cahill Guang Sun J Concepción Loredo-Osti Taraneh Abarin Effect of Gene and Physical Activity Interaction on Trunk Fat Percentage Among the Newfoundland Population |
topic_facet |
Genetics QH426-470 |
description |
Objective To explore the effect of FTO gene and physical activity interaction on trunk fat percentage. Design and Methods Subjects are 3,004 individuals from Newfoundland and Labrador whose trunk fat percentage and physical activity were recorded, and who were genotyped for 11 single-nucleotide polymorphisms (SNPs) in the FTO gene. Subjects were stratified by gender. Multiple tests and multiple regressions were used to analyze the effects of physical activity, variants of FTO , age, and their interactions on trunk fat percentage. Dietary information and other environmental factors were not considered. Results Higher levels of physical activity tend to reduce trunk fat percentage in all individuals. Furthermore, in males, rs9939609 and rs1421085 were significant (α = 0.05) in explaining central body fat, but no SNPs were significant in females. For highly active males, trunk fat percentage varied significantly between variants of rs9939609 and rs1421085, but there is no significant effect among individuals with low activity. The other SNPs examined were not significant in explaining trunk fat percentage. Conclusions Homozygous male carriers of non-obesity risk alleles at rs9939609 and rs1421085 will have significant reduction in central body fat from physical activity in contrast to homozygous males of the obesity-risk alleles. The additive effect of these SNPs is found in males with high physical activity only. |
format |
Article in Journal/Newspaper |
author |
Anthony Payne Farrell Cahill Guang Sun J Concepción Loredo-Osti Taraneh Abarin |
author_facet |
Anthony Payne Farrell Cahill Guang Sun J Concepción Loredo-Osti Taraneh Abarin |
author_sort |
Anthony Payne |
title |
Effect of Gene and Physical Activity Interaction on Trunk Fat Percentage Among the Newfoundland Population |
title_short |
Effect of Gene and Physical Activity Interaction on Trunk Fat Percentage Among the Newfoundland Population |
title_full |
Effect of Gene and Physical Activity Interaction on Trunk Fat Percentage Among the Newfoundland Population |
title_fullStr |
Effect of Gene and Physical Activity Interaction on Trunk Fat Percentage Among the Newfoundland Population |
title_full_unstemmed |
Effect of Gene and Physical Activity Interaction on Trunk Fat Percentage Among the Newfoundland Population |
title_sort |
effect of gene and physical activity interaction on trunk fat percentage among the newfoundland population |
publisher |
SAGE Publishing |
publishDate |
2014 |
url |
https://doi.org/10.4137/GEG.S14957 https://doaj.org/article/4187651518a84b62a69d2d07889a969d |
geographic |
Newfoundland |
geographic_facet |
Newfoundland |
genre |
Newfoundland |
genre_facet |
Newfoundland |
op_source |
Genetics and Epigenetics, Vol 6 (2014) |
op_relation |
https://doi.org/10.4137/GEG.S14957 https://doaj.org/toc/1179-237X 1179-237X doi:10.4137/GEG.S14957 https://doaj.org/article/4187651518a84b62a69d2d07889a969d |
op_doi |
https://doi.org/10.4137/GEG.S14957 |
container_title |
Genetics & Epigenetics |
container_volume |
6 |
container_start_page |
GEG.S14957 |
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1766106516717305856 |