Severe Plasmodium ovale malaria complicated by acute respiratory distress syndrome in a young Caucasian man

Abstract Background Although Plasmodium ovale is considered the cause of only mild malaria, a case of severe malaria due to P. ovale with acute respiratory distress syndrome is reported. Case presentation A 37-year old Caucasian man returning home from Angola was admitted for ovale malaria to the Na...

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Bibliographic Details
Published in:Malaria Journal
Main Authors: Alessandra D’Abramo, Saba Gebremeskel Tekle, Marco Iannetta, Laura Scorzolini, Alessandra Oliva, Maria Grazia Paglia, Angela Corpolongo, Emanuele Nicastri
Format: Article in Journal/Newspaper
Language:English
Published: BMC 2018
Subjects:
Plasmodium ovale
Malaria
ARDS
Chloroquine failure
Arctic medicine. Tropical medicine
RC955-962
Infectious and parasitic diseases
RC109-216
Arctic
Spallanzani
Online Access:https://doi.org/10.1186/s12936-018-2289-2
https://doaj.org/article/4145c316e93047efa6f469390f0e1db5
Description
Summary:Abstract Background Although Plasmodium ovale is considered the cause of only mild malaria, a case of severe malaria due to P. ovale with acute respiratory distress syndrome is reported. Case presentation A 37-year old Caucasian man returning home from Angola was admitted for ovale malaria to the National Institute for Infectious Diseases Lazzaro Spallanzani in Rome, Italy. Two days after initiation of oral chloroquine treatment, an acute respiratory distress syndrome was diagnosed through chest X-ray and chest CT scan with intravenous contrast. Intravenous artesunate and oral doxycycline were started and he made a full recovery. Conclusion Ovale malaria is usually considered a tropical infectious disease associated with low morbidity and mortality. However, severe disease and death have occasionally been reported. In this case clinical failure of oral chloroquine treatment with clinical progression towards acute respiratory distress syndrome is described.

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