East1 toxin and its presence in a changing microbial world
This review shows the structure, mode of action, and actual epidemiological data about EAST1 toxin. It is a particularly intriguing bacterial toxin that may subvert multiple cellular processes to yield intestinal epithelial cell secretion. EAST1 toxin was first described in strains of EAggEC that we...
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ftdoajarticles:oai:doaj.org/article:4143aaa79aa642338a845bd89d629cab 2023-05-15T15:04:20+02:00 East1 toxin and its presence in a changing microbial world C. P. Sousa 2003-01-01T00:00:00Z https://doi.org/10.1590/S1678-91992003000100002 https://doaj.org/article/4143aaa79aa642338a845bd89d629cab EN eng SciELO http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992003000100002 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992003000100002 1678-9199 https://doaj.org/article/4143aaa79aa642338a845bd89d629cab Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 9, Iss 1, Pp 4-52 (2003) EAST1 toxin astA gene virulence in Escherichia coli virulence in Salmonella spp Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article 2003 ftdoajarticles https://doi.org/10.1590/S1678-91992003000100002 2022-12-31T03:29:35Z This review shows the structure, mode of action, and actual epidemiological data about EAST1 toxin. It is a particularly intriguing bacterial toxin that may subvert multiple cellular processes to yield intestinal epithelial cell secretion. EAST1 toxin was first described in strains of EAggEC that were associated with persistent diarrhea primarily in developing world countries. Molecular organization, mobility, and data in literature are suggesting that EAST1 could be a transposon. The insertion sequences in Escherichia coli and some of the usual transposition mechanisms as well as regulation are reviewed. This review emphasizes the presence of the gene astA in EPEC, EAggEC, A-EPEC, ETEC, DAEC, EIEC, and in non-diarrheagenic E. coli. It also discusses here the presence of the astA gene in Salmonella spp. and future perspectives for understanding its role in diarrheal disease in both bacterial genera. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Venomous Animals and Toxins including Tropical Diseases 9 1 4 52 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
EAST1 toxin astA gene virulence in Escherichia coli virulence in Salmonella spp Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
spellingShingle |
EAST1 toxin astA gene virulence in Escherichia coli virulence in Salmonella spp Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 C. P. Sousa East1 toxin and its presence in a changing microbial world |
topic_facet |
EAST1 toxin astA gene virulence in Escherichia coli virulence in Salmonella spp Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
description |
This review shows the structure, mode of action, and actual epidemiological data about EAST1 toxin. It is a particularly intriguing bacterial toxin that may subvert multiple cellular processes to yield intestinal epithelial cell secretion. EAST1 toxin was first described in strains of EAggEC that were associated with persistent diarrhea primarily in developing world countries. Molecular organization, mobility, and data in literature are suggesting that EAST1 could be a transposon. The insertion sequences in Escherichia coli and some of the usual transposition mechanisms as well as regulation are reviewed. This review emphasizes the presence of the gene astA in EPEC, EAggEC, A-EPEC, ETEC, DAEC, EIEC, and in non-diarrheagenic E. coli. It also discusses here the presence of the astA gene in Salmonella spp. and future perspectives for understanding its role in diarrheal disease in both bacterial genera. |
format |
Article in Journal/Newspaper |
author |
C. P. Sousa |
author_facet |
C. P. Sousa |
author_sort |
C. P. Sousa |
title |
East1 toxin and its presence in a changing microbial world |
title_short |
East1 toxin and its presence in a changing microbial world |
title_full |
East1 toxin and its presence in a changing microbial world |
title_fullStr |
East1 toxin and its presence in a changing microbial world |
title_full_unstemmed |
East1 toxin and its presence in a changing microbial world |
title_sort |
east1 toxin and its presence in a changing microbial world |
publisher |
SciELO |
publishDate |
2003 |
url |
https://doi.org/10.1590/S1678-91992003000100002 https://doaj.org/article/4143aaa79aa642338a845bd89d629cab |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 9, Iss 1, Pp 4-52 (2003) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992003000100002 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992003000100002 1678-9199 https://doaj.org/article/4143aaa79aa642338a845bd89d629cab |
op_doi |
https://doi.org/10.1590/S1678-91992003000100002 |
container_title |
Journal of Venomous Animals and Toxins including Tropical Diseases |
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9 |
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1 |
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4 |
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52 |
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1766336124665462784 |