Naturally induced humoral response against Plasmodium vivax reticulocyte binding protein 2P1
Abstract Background Plasmodium vivax is the most prevalent malaria parasite in many countries. A better understanding of human immunity to this parasite can provide new insights for vaccine development. Plasmodium vivax Reticulocyte Binding Proteins (RBPs) are key parasite proteins that interact wit...
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ftdoajarticles:oai:doaj.org/article:413df681f5104c10b8ef54ed8d29e20e 2023-05-15T15:11:14+02:00 Naturally induced humoral response against Plasmodium vivax reticulocyte binding protein 2P1 Jenni Hietanen Anongruk Chim-ong Jetsumon Sattabongkot Wang Nguitragool 2021-06-01T00:00:00Z https://doi.org/10.1186/s12936-021-03784-1 https://doaj.org/article/413df681f5104c10b8ef54ed8d29e20e EN eng BMC https://doi.org/10.1186/s12936-021-03784-1 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-021-03784-1 1475-2875 https://doaj.org/article/413df681f5104c10b8ef54ed8d29e20e Malaria Journal, Vol 20, Iss 1, Pp 1-11 (2021) Plasmodium vivax Malaria Cytophilic Complement Antibody Serology Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2021 ftdoajarticles https://doi.org/10.1186/s12936-021-03784-1 2022-12-31T09:38:42Z Abstract Background Plasmodium vivax is the most prevalent malaria parasite in many countries. A better understanding of human immunity to this parasite can provide new insights for vaccine development. Plasmodium vivax Reticulocyte Binding Proteins (RBPs) are key parasite proteins that interact with human proteins during erythrocyte invasion and are targets of the human immune response. The aim of this study is to characterize the human antibody response to RBP2P1, the most recently described member of the RBP family. Methods The levels of total IgG and IgM against RBP2P1 were measured using plasmas from 68 P. vivax malaria patients and 525 villagers in a malarious village of western Thailand. The latter group comprises asymptomatic carriers and healthy uninfected individuals. Subsets of plasma samples were evaluated for anti-RBP2P1 IgG subtypes and complement-fixing activity. Results As age increased, it was found that the level of anti-RBP2P1 IgG increased while the level of IgM decreased. The main anti-RBP2P1 IgG subtypes were IgG1 and IgG3. The IgG3-seropositive rate was higher in asymptomatic carriers than in patients. The higher level of IgG3 was correlated with higher in vitro RBP2P1-mediated complement fixing activity. Conclusions In natural infection, the primary IgG response to RBP2P1 was IgG1 and IgG3. The predominance of these cytophilic subtypes and the elevated level of IgG3 correlating with complement fixing activity, suggest a possible role of anti-RBP2P1 antibodies in immunity against P. vivax. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 20 1 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
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Plasmodium vivax Malaria Cytophilic Complement Antibody Serology Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Plasmodium vivax Malaria Cytophilic Complement Antibody Serology Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Jenni Hietanen Anongruk Chim-ong Jetsumon Sattabongkot Wang Nguitragool Naturally induced humoral response against Plasmodium vivax reticulocyte binding protein 2P1 |
topic_facet |
Plasmodium vivax Malaria Cytophilic Complement Antibody Serology Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Plasmodium vivax is the most prevalent malaria parasite in many countries. A better understanding of human immunity to this parasite can provide new insights for vaccine development. Plasmodium vivax Reticulocyte Binding Proteins (RBPs) are key parasite proteins that interact with human proteins during erythrocyte invasion and are targets of the human immune response. The aim of this study is to characterize the human antibody response to RBP2P1, the most recently described member of the RBP family. Methods The levels of total IgG and IgM against RBP2P1 were measured using plasmas from 68 P. vivax malaria patients and 525 villagers in a malarious village of western Thailand. The latter group comprises asymptomatic carriers and healthy uninfected individuals. Subsets of plasma samples were evaluated for anti-RBP2P1 IgG subtypes and complement-fixing activity. Results As age increased, it was found that the level of anti-RBP2P1 IgG increased while the level of IgM decreased. The main anti-RBP2P1 IgG subtypes were IgG1 and IgG3. The IgG3-seropositive rate was higher in asymptomatic carriers than in patients. The higher level of IgG3 was correlated with higher in vitro RBP2P1-mediated complement fixing activity. Conclusions In natural infection, the primary IgG response to RBP2P1 was IgG1 and IgG3. The predominance of these cytophilic subtypes and the elevated level of IgG3 correlating with complement fixing activity, suggest a possible role of anti-RBP2P1 antibodies in immunity against P. vivax. |
format |
Article in Journal/Newspaper |
author |
Jenni Hietanen Anongruk Chim-ong Jetsumon Sattabongkot Wang Nguitragool |
author_facet |
Jenni Hietanen Anongruk Chim-ong Jetsumon Sattabongkot Wang Nguitragool |
author_sort |
Jenni Hietanen |
title |
Naturally induced humoral response against Plasmodium vivax reticulocyte binding protein 2P1 |
title_short |
Naturally induced humoral response against Plasmodium vivax reticulocyte binding protein 2P1 |
title_full |
Naturally induced humoral response against Plasmodium vivax reticulocyte binding protein 2P1 |
title_fullStr |
Naturally induced humoral response against Plasmodium vivax reticulocyte binding protein 2P1 |
title_full_unstemmed |
Naturally induced humoral response against Plasmodium vivax reticulocyte binding protein 2P1 |
title_sort |
naturally induced humoral response against plasmodium vivax reticulocyte binding protein 2p1 |
publisher |
BMC |
publishDate |
2021 |
url |
https://doi.org/10.1186/s12936-021-03784-1 https://doaj.org/article/413df681f5104c10b8ef54ed8d29e20e |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 20, Iss 1, Pp 1-11 (2021) |
op_relation |
https://doi.org/10.1186/s12936-021-03784-1 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-021-03784-1 1475-2875 https://doaj.org/article/413df681f5104c10b8ef54ed8d29e20e |
op_doi |
https://doi.org/10.1186/s12936-021-03784-1 |
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Malaria Journal |
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20 |
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1 |
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1766342124021743616 |