Adverse drug events and the associated factors in patients with chronic Chagas disease

Abstract INTRODUCTION: Herein, we aimed to identify the factors associated with adverse drug events (ADEs) in chronic Chagas disease (CD) patients. METHODS: We analyzed 320 medical notes from 295 patients. The Naranjo algorithm was applied to determine the cause of ADEs. Mixed effects logistic regre...

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Bibliographic Details
Published in:Revista da Sociedade Brasileira de Medicina Tropical
Main Authors: Luiza Braz da Cunha Lopes, Raquel Rodrigues Pereira, Patricia Mello Andrade, Fernanda Martins Carneiro, Mauro Felippe Felix Mediano, Sophia Isabel Linnemann Kilgore, Alejandro Marcel Hasslocher-Moreno, Andréa Silvestre de Sousa, Manoel Marques Evangelista Oliveira, Roberto Magalhães Saraiva, Marcelo Teixeira de Holanda, Gilberto Marcelo Sperandio da Silva
Format: Article in Journal/Newspaper
Language:English
Published: Sociedade Brasileira de Medicina Tropical (SBMT) 2020
Subjects:
Chagas disease
Adverse drug event
Cardiomyopathy
Arctic medicine. Tropical medicine
RC955-962
Arctic
Online Access:https://doi.org/10.1590/0037-8682-0443-2019
https://doaj.org/article/40e0a186c7844dee8256032d02c4f987
Description
Summary:Abstract INTRODUCTION: Herein, we aimed to identify the factors associated with adverse drug events (ADEs) in chronic Chagas disease (CD) patients. METHODS: We analyzed 320 medical notes from 295 patients. The Naranjo algorithm was applied to determine the cause of ADEs. Mixed effects logistic regression was performed to evaluate the factors associated with ADEs. RESULTS: ADEs were described in 102 medical notes (31.9%). Captopril was most frequently associated with ADEs. Age (RR 0.96; 95%CI 0.94-0.99) and cardiac C/D stages (RR 3.24; 95%CI 1.30-4.58) were the most important clinical factors associated with ADEs. CONCLUSIONS: Close follow-up is warranted for CD patients.

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