Unlocking the biosynthetic potential and taxonomy of the Antarctic microbiome along temporal and spatial gradients
ABSTRACT Extreme environments, such as Antarctica, select microbial communities that display a range of evolutionary strategies to survive and thrive under harsh environmental conditions. These include a diversity of specialized metabolites, which have the potential to be a source for new natural pr...
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ftdoajarticles:oai:doaj.org/article:40d43f969ff041098b88b31cbcbee083 2024-09-15T17:48:17+00:00 Unlocking the biosynthetic potential and taxonomy of the Antarctic microbiome along temporal and spatial gradients William Medeiros Kelly Hidalgo Tiago Leão Lucas Miguel de Carvalho Nadine Ziemert Valeria Oliveira 2024-06-01T00:00:00Z https://doi.org/10.1128/spectrum.00244-24 https://doaj.org/article/40d43f969ff041098b88b31cbcbee083 EN eng American Society for Microbiology https://journals.asm.org/doi/10.1128/spectrum.00244-24 https://doaj.org/toc/2165-0497 doi:10.1128/spectrum.00244-24 2165-0497 https://doaj.org/article/40d43f969ff041098b88b31cbcbee083 Microbiology Spectrum, Vol 12, Iss 6 (2024) biosynthetic gene clusters metagenome mining Antarctic environments Whalers Bay Microbiology QR1-502 article 2024 ftdoajarticles https://doi.org/10.1128/spectrum.00244-24 2024-08-05T17:49:15Z ABSTRACT Extreme environments, such as Antarctica, select microbial communities that display a range of evolutionary strategies to survive and thrive under harsh environmental conditions. These include a diversity of specialized metabolites, which have the potential to be a source for new natural product discovery. Efforts using (meta)genome mining approaches to identify and understand biosynthetic gene clusters in Antarctica are still scarce, and the extent of their diversity and distribution patterns in the environment have yet to be discovered. Herein, we investigated the biosynthetic gene diversity of the biofilm microbial community of Whalers Bay, Deception Island, in the Antarctic Peninsula and revealed its distribution patterns along spatial and temporal gradients by applying metagenome mining approaches and multivariable analysis. The results showed that the Whalers Bay microbial community harbors a great diversity of biosynthetic gene clusters distributed into seven classes, with terpene being the most abundant. The phyla Proteobacteria and Bacteroidota were the most abundant in the microbial community and contributed significantly to the biosynthetic gene abundances in Whalers Bay. Furthermore, the results highlighted a significant correlation between the distribution of biosynthetic genes and taxonomic diversity, emphasizing the intricate interplay between microbial taxonomy and their potential for specialized metabolite production.IMPORTANCEThis research on antarctic microbial biosynthetic diversity in Whalers Bay, Deception Island, unveils the hidden potential of extreme environments for natural product discovery. By employing metagenomic techniques, the research highlights the extensive diversity of biosynthetic gene clusters and identifies key microbial phyla, Proteobacteria and Bacteroidota, as significant contributors. The correlation between taxonomic diversity and biosynthetic gene distribution underscores the intricate interplay governing specialized metabolite production. These findings are ... Article in Journal/Newspaper Antarc* Antarctic Antarctic Peninsula Antarctica Deception Island Directory of Open Access Journals: DOAJ Articles Microbiology Spectrum 12 6 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
biosynthetic gene clusters metagenome mining Antarctic environments Whalers Bay Microbiology QR1-502 |
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biosynthetic gene clusters metagenome mining Antarctic environments Whalers Bay Microbiology QR1-502 William Medeiros Kelly Hidalgo Tiago Leão Lucas Miguel de Carvalho Nadine Ziemert Valeria Oliveira Unlocking the biosynthetic potential and taxonomy of the Antarctic microbiome along temporal and spatial gradients |
topic_facet |
biosynthetic gene clusters metagenome mining Antarctic environments Whalers Bay Microbiology QR1-502 |
description |
ABSTRACT Extreme environments, such as Antarctica, select microbial communities that display a range of evolutionary strategies to survive and thrive under harsh environmental conditions. These include a diversity of specialized metabolites, which have the potential to be a source for new natural product discovery. Efforts using (meta)genome mining approaches to identify and understand biosynthetic gene clusters in Antarctica are still scarce, and the extent of their diversity and distribution patterns in the environment have yet to be discovered. Herein, we investigated the biosynthetic gene diversity of the biofilm microbial community of Whalers Bay, Deception Island, in the Antarctic Peninsula and revealed its distribution patterns along spatial and temporal gradients by applying metagenome mining approaches and multivariable analysis. The results showed that the Whalers Bay microbial community harbors a great diversity of biosynthetic gene clusters distributed into seven classes, with terpene being the most abundant. The phyla Proteobacteria and Bacteroidota were the most abundant in the microbial community and contributed significantly to the biosynthetic gene abundances in Whalers Bay. Furthermore, the results highlighted a significant correlation between the distribution of biosynthetic genes and taxonomic diversity, emphasizing the intricate interplay between microbial taxonomy and their potential for specialized metabolite production.IMPORTANCEThis research on antarctic microbial biosynthetic diversity in Whalers Bay, Deception Island, unveils the hidden potential of extreme environments for natural product discovery. By employing metagenomic techniques, the research highlights the extensive diversity of biosynthetic gene clusters and identifies key microbial phyla, Proteobacteria and Bacteroidota, as significant contributors. The correlation between taxonomic diversity and biosynthetic gene distribution underscores the intricate interplay governing specialized metabolite production. These findings are ... |
format |
Article in Journal/Newspaper |
author |
William Medeiros Kelly Hidalgo Tiago Leão Lucas Miguel de Carvalho Nadine Ziemert Valeria Oliveira |
author_facet |
William Medeiros Kelly Hidalgo Tiago Leão Lucas Miguel de Carvalho Nadine Ziemert Valeria Oliveira |
author_sort |
William Medeiros |
title |
Unlocking the biosynthetic potential and taxonomy of the Antarctic microbiome along temporal and spatial gradients |
title_short |
Unlocking the biosynthetic potential and taxonomy of the Antarctic microbiome along temporal and spatial gradients |
title_full |
Unlocking the biosynthetic potential and taxonomy of the Antarctic microbiome along temporal and spatial gradients |
title_fullStr |
Unlocking the biosynthetic potential and taxonomy of the Antarctic microbiome along temporal and spatial gradients |
title_full_unstemmed |
Unlocking the biosynthetic potential and taxonomy of the Antarctic microbiome along temporal and spatial gradients |
title_sort |
unlocking the biosynthetic potential and taxonomy of the antarctic microbiome along temporal and spatial gradients |
publisher |
American Society for Microbiology |
publishDate |
2024 |
url |
https://doi.org/10.1128/spectrum.00244-24 https://doaj.org/article/40d43f969ff041098b88b31cbcbee083 |
genre |
Antarc* Antarctic Antarctic Peninsula Antarctica Deception Island |
genre_facet |
Antarc* Antarctic Antarctic Peninsula Antarctica Deception Island |
op_source |
Microbiology Spectrum, Vol 12, Iss 6 (2024) |
op_relation |
https://journals.asm.org/doi/10.1128/spectrum.00244-24 https://doaj.org/toc/2165-0497 doi:10.1128/spectrum.00244-24 2165-0497 https://doaj.org/article/40d43f969ff041098b88b31cbcbee083 |
op_doi |
https://doi.org/10.1128/spectrum.00244-24 |
container_title |
Microbiology Spectrum |
container_volume |
12 |
container_issue |
6 |
_version_ |
1810289437112795136 |