Methodology of clinical trials aimed at assessing interventions for cutaneous leishmaniasis.
The current evidence-base for recommendations on the treatment of cutaneous leishmaniasis (CL) is generally weak. Systematic reviews have pointed to a general lack of standardization of methods for the conduct and analysis of clinical trials of CL, compounded with poor overall quality of several tri...
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ftdoajarticles:oai:doaj.org/article:4095eff5c5754f3b90248ec3efdfd325 2023-05-15T15:03:14+02:00 Methodology of clinical trials aimed at assessing interventions for cutaneous leishmaniasis. Piero Olliaro Michel Vaillant Byron Arana Max Grogl Farrokh Modabber Alan Magill Olivier Lapujade Pierre Buffet Jorge Alvar 2013-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0002130 https://doaj.org/article/4095eff5c5754f3b90248ec3efdfd325 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3605149?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0002130 https://doaj.org/article/4095eff5c5754f3b90248ec3efdfd325 PLoS Neglected Tropical Diseases, Vol 7, Iss 3, p e2130 (2013) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2013 ftdoajarticles https://doi.org/10.1371/journal.pntd.0002130 2022-12-31T03:15:26Z The current evidence-base for recommendations on the treatment of cutaneous leishmaniasis (CL) is generally weak. Systematic reviews have pointed to a general lack of standardization of methods for the conduct and analysis of clinical trials of CL, compounded with poor overall quality of several trials. For CL, there is a specific need for methodologies which can be applied generally, while allowing the flexibility needed to cover the diverse forms of the disease. This paper intends to provide clinical investigators with guidance for the design, conduct, analysis and report of clinical trials of treatments for CL, including the definition of measurable, reproducible and clinically-meaningful outcomes. Having unified criteria will help strengthen evidence, optimize investments, and enhance the capacity for high-quality trials. The limited resources available for CL have to be concentrated in clinical studies of excellence that meet international quality standards. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 7 3 e2130 |
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Directory of Open Access Journals: DOAJ Articles |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Piero Olliaro Michel Vaillant Byron Arana Max Grogl Farrokh Modabber Alan Magill Olivier Lapujade Pierre Buffet Jorge Alvar Methodology of clinical trials aimed at assessing interventions for cutaneous leishmaniasis. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
The current evidence-base for recommendations on the treatment of cutaneous leishmaniasis (CL) is generally weak. Systematic reviews have pointed to a general lack of standardization of methods for the conduct and analysis of clinical trials of CL, compounded with poor overall quality of several trials. For CL, there is a specific need for methodologies which can be applied generally, while allowing the flexibility needed to cover the diverse forms of the disease. This paper intends to provide clinical investigators with guidance for the design, conduct, analysis and report of clinical trials of treatments for CL, including the definition of measurable, reproducible and clinically-meaningful outcomes. Having unified criteria will help strengthen evidence, optimize investments, and enhance the capacity for high-quality trials. The limited resources available for CL have to be concentrated in clinical studies of excellence that meet international quality standards. |
format |
Article in Journal/Newspaper |
author |
Piero Olliaro Michel Vaillant Byron Arana Max Grogl Farrokh Modabber Alan Magill Olivier Lapujade Pierre Buffet Jorge Alvar |
author_facet |
Piero Olliaro Michel Vaillant Byron Arana Max Grogl Farrokh Modabber Alan Magill Olivier Lapujade Pierre Buffet Jorge Alvar |
author_sort |
Piero Olliaro |
title |
Methodology of clinical trials aimed at assessing interventions for cutaneous leishmaniasis. |
title_short |
Methodology of clinical trials aimed at assessing interventions for cutaneous leishmaniasis. |
title_full |
Methodology of clinical trials aimed at assessing interventions for cutaneous leishmaniasis. |
title_fullStr |
Methodology of clinical trials aimed at assessing interventions for cutaneous leishmaniasis. |
title_full_unstemmed |
Methodology of clinical trials aimed at assessing interventions for cutaneous leishmaniasis. |
title_sort |
methodology of clinical trials aimed at assessing interventions for cutaneous leishmaniasis. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2013 |
url |
https://doi.org/10.1371/journal.pntd.0002130 https://doaj.org/article/4095eff5c5754f3b90248ec3efdfd325 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 7, Iss 3, p e2130 (2013) |
op_relation |
http://europepmc.org/articles/PMC3605149?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0002130 https://doaj.org/article/4095eff5c5754f3b90248ec3efdfd325 |
op_doi |
https://doi.org/10.1371/journal.pntd.0002130 |
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PLoS Neglected Tropical Diseases |
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7 |
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3 |
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e2130 |
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