LEPR polymorphisms and haplotypes in Mexican patients with colorectal cancer
Introduction: Obesity and colorectal cancer could be linked by adipocytokines, which are proteins associated with cell proliferation. High levels of the adipocytokine leptin promote the development of colorectal cancer through its receptor. Objective: To determine the association between c.326A>G...
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ftdoajarticles:oai:doaj.org/article:405655b08b4540a79c2207a282ddb7fc 2023-05-15T15:08:52+02:00 LEPR polymorphisms and haplotypes in Mexican patients with colorectal cancer Miriam Partida Melva Gutiérrez María de la Luz Ayala Nelly Margarita Macías Carlos Rogelio Alvizo Jorge Peregrina 2019-03-01T00:00:00Z https://doi.org/10.7705/biomedica.v39i1.4091 https://doaj.org/article/405655b08b4540a79c2207a282ddb7fc EN ES eng spa Instituto Nacional de Salud https://www.revistabiomedica.org/index.php/biomedica/article/view/4091 https://doaj.org/toc/0120-4157 0120-4157 doi:10.7705/biomedica.v39i1.4091 https://doaj.org/article/405655b08b4540a79c2207a282ddb7fc Biomédica: revista del Instituto Nacional de Salud, Vol 39, Iss 1, Pp 205-211 (2019) Opportunistic infections/epidemiology HIV infections socioeconomic factors health status disparities health systems Medicine R Arctic medicine. Tropical medicine RC955-962 article 2019 ftdoajarticles https://doi.org/10.7705/biomedica.v39i1.4091 2022-12-30T23:12:43Z Introduction: Obesity and colorectal cancer could be linked by adipocytokines, which are proteins associated with cell proliferation. High levels of the adipocytokine leptin promote the development of colorectal cancer through its receptor. Objective: To determine the association between c.326A>G and c.668A>G LEPR gene polymorphisms and colorectal cancer. Materials and methods: DNA was extracted from the peripheral blood of 147 patients with sporadic colorectal cancer and 134 healthy people. Genotypes were obtained by PCRRFLP and the association was determined by the odds ratio (OR) test using the SPSS™, version 10.0, program. Haplotype frequencies and linkage disequilibrium were estimated by the Arlequin, version 3.5, software. Results: Both polymorphisms were in Hardy-Weinberg equilibrium. Only the c.326A>G heterozygous genotype revealed an increased risk for colorectal cancer development (OR=1.81, 95% CI=1.04-3.16, p=0.04). The AG haplotype showed a significant association with colorectal cancer (OR=0.58, 95% CI=0.35-0.96, p<0.03). Linkage disequilibrium between the variants was only evident for the patients group (r2=0.36). Conclusion: Our results suggest that AG individuals heterozygous for the c.326A>G LEPR variant have a higher risk of colorectal cancer development whereas the AG haplotype (c.326A/c.668G) has a protective effect in the Mexican population. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Biomédica 39 1 205 211 |
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topic |
Opportunistic infections/epidemiology HIV infections socioeconomic factors health status disparities health systems Medicine R Arctic medicine. Tropical medicine RC955-962 |
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Opportunistic infections/epidemiology HIV infections socioeconomic factors health status disparities health systems Medicine R Arctic medicine. Tropical medicine RC955-962 Miriam Partida Melva Gutiérrez María de la Luz Ayala Nelly Margarita Macías Carlos Rogelio Alvizo Jorge Peregrina LEPR polymorphisms and haplotypes in Mexican patients with colorectal cancer |
topic_facet |
Opportunistic infections/epidemiology HIV infections socioeconomic factors health status disparities health systems Medicine R Arctic medicine. Tropical medicine RC955-962 |
description |
Introduction: Obesity and colorectal cancer could be linked by adipocytokines, which are proteins associated with cell proliferation. High levels of the adipocytokine leptin promote the development of colorectal cancer through its receptor. Objective: To determine the association between c.326A>G and c.668A>G LEPR gene polymorphisms and colorectal cancer. Materials and methods: DNA was extracted from the peripheral blood of 147 patients with sporadic colorectal cancer and 134 healthy people. Genotypes were obtained by PCRRFLP and the association was determined by the odds ratio (OR) test using the SPSS™, version 10.0, program. Haplotype frequencies and linkage disequilibrium were estimated by the Arlequin, version 3.5, software. Results: Both polymorphisms were in Hardy-Weinberg equilibrium. Only the c.326A>G heterozygous genotype revealed an increased risk for colorectal cancer development (OR=1.81, 95% CI=1.04-3.16, p=0.04). The AG haplotype showed a significant association with colorectal cancer (OR=0.58, 95% CI=0.35-0.96, p<0.03). Linkage disequilibrium between the variants was only evident for the patients group (r2=0.36). Conclusion: Our results suggest that AG individuals heterozygous for the c.326A>G LEPR variant have a higher risk of colorectal cancer development whereas the AG haplotype (c.326A/c.668G) has a protective effect in the Mexican population. |
format |
Article in Journal/Newspaper |
author |
Miriam Partida Melva Gutiérrez María de la Luz Ayala Nelly Margarita Macías Carlos Rogelio Alvizo Jorge Peregrina |
author_facet |
Miriam Partida Melva Gutiérrez María de la Luz Ayala Nelly Margarita Macías Carlos Rogelio Alvizo Jorge Peregrina |
author_sort |
Miriam Partida |
title |
LEPR polymorphisms and haplotypes in Mexican patients with colorectal cancer |
title_short |
LEPR polymorphisms and haplotypes in Mexican patients with colorectal cancer |
title_full |
LEPR polymorphisms and haplotypes in Mexican patients with colorectal cancer |
title_fullStr |
LEPR polymorphisms and haplotypes in Mexican patients with colorectal cancer |
title_full_unstemmed |
LEPR polymorphisms and haplotypes in Mexican patients with colorectal cancer |
title_sort |
lepr polymorphisms and haplotypes in mexican patients with colorectal cancer |
publisher |
Instituto Nacional de Salud |
publishDate |
2019 |
url |
https://doi.org/10.7705/biomedica.v39i1.4091 https://doaj.org/article/405655b08b4540a79c2207a282ddb7fc |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Biomédica: revista del Instituto Nacional de Salud, Vol 39, Iss 1, Pp 205-211 (2019) |
op_relation |
https://www.revistabiomedica.org/index.php/biomedica/article/view/4091 https://doaj.org/toc/0120-4157 0120-4157 doi:10.7705/biomedica.v39i1.4091 https://doaj.org/article/405655b08b4540a79c2207a282ddb7fc |
op_doi |
https://doi.org/10.7705/biomedica.v39i1.4091 |
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Biomédica |
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39 |
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1 |
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205 |
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211 |
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