Influence of different cultivars of Phoenix dactylifera L-date fruits on blood clotting and wound healing
Objective: To investigate different types of dates and medical properties of influencing blood clotting and wound healing in an animal model. Methods: Three different cultivars of dates (Ajwa, Khalas, and Fardh) were examined in-vivo, for blood clotting and wound healing using CD1 mice of both sexes...
Published in: | Asian Pacific Journal of Tropical Biomedicine |
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Wolters Kluwer Medknow Publications
2018
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ftdoajarticles:oai:doaj.org/article:404b8592c3714c33a991cc60f680081a 2023-05-15T15:16:21+02:00 Influence of different cultivars of Phoenix dactylifera L-date fruits on blood clotting and wound healing S S Hasson M S Al-Shaqsi J Z Albusaidi M S Al-Balushi F L Hakkim G M Aleemallah A A Al-Jabri 2018-01-01T00:00:00Z https://doi.org/10.4103/2221-1691.237081 https://doaj.org/article/404b8592c3714c33a991cc60f680081a EN eng Wolters Kluwer Medknow Publications http://www.apjtb.org/article.asp?issn=2221-1691;year=2018;volume=8;issue=7;spage=371;epage=376;aulast=Hasson https://doaj.org/toc/2221-1691 2221-1691 doi:10.4103/2221-1691.237081 https://doaj.org/article/404b8592c3714c33a991cc60f680081a Asian Pacific Journal of Tropical Biomedicine, Vol 8, Iss 7, Pp 371-376 (2018) phoenix dactylifera l prothrombin time wound healing bleeding time Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2018 ftdoajarticles https://doi.org/10.4103/2221-1691.237081 2022-12-31T01:27:08Z Objective: To investigate different types of dates and medical properties of influencing blood clotting and wound healing in an animal model. Methods: Three different cultivars of dates (Ajwa, Khalas, and Fardh) were examined in-vivo, for blood clotting and wound healing using CD1 mice of both sexes. Study of toxicity to animals was performed accordingly prior to further investigations. The ethanolic extracts were given orally to animals as a constituent in their daily water. Blood samples were obtained from the mice inferior vena cava to carry out the prothrombin time (PT) assay using the manual method and confirmed using a semi-automated machine. The bleeding time (BT) assay was performed using the cutting technique. In the wound healing analysis, a small cut (5-10 mm) in the skin overlying the thigh was conducted in all mice under anesthesia. The diameter of the cut and healing status were measured on a daily basis throughout the time of the experiment using a roller. Results: Ajwa was able to elevate both PT and BT (P<0.05), significantly in a time-dependent manner followed by Khalas date (P<0.05). The results of PT and BT of Fardh date were found to be very close to those of the control group (P<0.05). Despite its activity as an anticoagulant, Khalas date showed a potential property to enhance wound healing in contrast to other dates and the control groups in this study. Conclusions: Omani Khalas date fruit has both antithrombotic as well as wound healing properties. The results open a new gate with these fruits for exploring the potential component(s) that may play an important role in antithrombotic as well as wound healing process. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 8 7 371 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
topic |
phoenix dactylifera l prothrombin time wound healing bleeding time Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
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phoenix dactylifera l prothrombin time wound healing bleeding time Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 S S Hasson M S Al-Shaqsi J Z Albusaidi M S Al-Balushi F L Hakkim G M Aleemallah A A Al-Jabri Influence of different cultivars of Phoenix dactylifera L-date fruits on blood clotting and wound healing |
topic_facet |
phoenix dactylifera l prothrombin time wound healing bleeding time Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To investigate different types of dates and medical properties of influencing blood clotting and wound healing in an animal model. Methods: Three different cultivars of dates (Ajwa, Khalas, and Fardh) were examined in-vivo, for blood clotting and wound healing using CD1 mice of both sexes. Study of toxicity to animals was performed accordingly prior to further investigations. The ethanolic extracts were given orally to animals as a constituent in their daily water. Blood samples were obtained from the mice inferior vena cava to carry out the prothrombin time (PT) assay using the manual method and confirmed using a semi-automated machine. The bleeding time (BT) assay was performed using the cutting technique. In the wound healing analysis, a small cut (5-10 mm) in the skin overlying the thigh was conducted in all mice under anesthesia. The diameter of the cut and healing status were measured on a daily basis throughout the time of the experiment using a roller. Results: Ajwa was able to elevate both PT and BT (P<0.05), significantly in a time-dependent manner followed by Khalas date (P<0.05). The results of PT and BT of Fardh date were found to be very close to those of the control group (P<0.05). Despite its activity as an anticoagulant, Khalas date showed a potential property to enhance wound healing in contrast to other dates and the control groups in this study. Conclusions: Omani Khalas date fruit has both antithrombotic as well as wound healing properties. The results open a new gate with these fruits for exploring the potential component(s) that may play an important role in antithrombotic as well as wound healing process. |
format |
Article in Journal/Newspaper |
author |
S S Hasson M S Al-Shaqsi J Z Albusaidi M S Al-Balushi F L Hakkim G M Aleemallah A A Al-Jabri |
author_facet |
S S Hasson M S Al-Shaqsi J Z Albusaidi M S Al-Balushi F L Hakkim G M Aleemallah A A Al-Jabri |
author_sort |
S S Hasson |
title |
Influence of different cultivars of Phoenix dactylifera L-date fruits on blood clotting and wound healing |
title_short |
Influence of different cultivars of Phoenix dactylifera L-date fruits on blood clotting and wound healing |
title_full |
Influence of different cultivars of Phoenix dactylifera L-date fruits on blood clotting and wound healing |
title_fullStr |
Influence of different cultivars of Phoenix dactylifera L-date fruits on blood clotting and wound healing |
title_full_unstemmed |
Influence of different cultivars of Phoenix dactylifera L-date fruits on blood clotting and wound healing |
title_sort |
influence of different cultivars of phoenix dactylifera l-date fruits on blood clotting and wound healing |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2018 |
url |
https://doi.org/10.4103/2221-1691.237081 https://doaj.org/article/404b8592c3714c33a991cc60f680081a |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 8, Iss 7, Pp 371-376 (2018) |
op_relation |
http://www.apjtb.org/article.asp?issn=2221-1691;year=2018;volume=8;issue=7;spage=371;epage=376;aulast=Hasson https://doaj.org/toc/2221-1691 2221-1691 doi:10.4103/2221-1691.237081 https://doaj.org/article/404b8592c3714c33a991cc60f680081a |
op_doi |
https://doi.org/10.4103/2221-1691.237081 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
8 |
container_issue |
7 |
container_start_page |
371 |
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1766346636876840960 |