Genomic African and Native American Ancestry and Chagas Disease: The Bambui (Brazil) Epigen Cohort Study of Aging.
The influence of genetic ancestry on Trypanosoma cruzi infection and Chagas disease outcomes is unknown.We used 370,539 Single Nucleotide Polymorphisms (SNPs) to examine the association between individual proportions of African, European and Native American genomic ancestry with T. cruzi infection a...
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ftdoajarticles:oai:doaj.org/article:402cd2a1ff7a4982b0611eb89a88a37e 2023-05-15T15:13:54+02:00 Genomic African and Native American Ancestry and Chagas Disease: The Bambui (Brazil) Epigen Cohort Study of Aging. M Fernanda Lima-Costa James Macinko Juliana Vaz de Mello Mambrini Sérgio Viana Peixoto Alexandre Costa Pereira Eduardo Tarazona-Santos Antonio Luiz Pinho Ribeiro 2016-05-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0004724 https://doaj.org/article/402cd2a1ff7a4982b0611eb89a88a37e EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4868305?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004724 https://doaj.org/article/402cd2a1ff7a4982b0611eb89a88a37e PLoS Neglected Tropical Diseases, Vol 10, Iss 5, p e0004724 (2016) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2016 ftdoajarticles https://doi.org/10.1371/journal.pntd.0004724 2022-12-30T21:57:33Z The influence of genetic ancestry on Trypanosoma cruzi infection and Chagas disease outcomes is unknown.We used 370,539 Single Nucleotide Polymorphisms (SNPs) to examine the association between individual proportions of African, European and Native American genomic ancestry with T. cruzi infection and related outcomes in 1,341 participants (aged ≥ 60 years) of the Bambui (Brazil) population-based cohort study of aging. Potential confounding variables included sociodemographic characteristics and an array of health measures. The prevalence of T. cruzi infection was 37.5% and 56.3% of those infected had a major ECG abnormality. Baseline T. cruzi infection was correlated with higher levels of African and Native American ancestry, which in turn were strongly associated with poor socioeconomic circumstances. Cardiomyopathy in infected persons was not significantly associated with African or Native American ancestry levels. Infected persons with a major ECG abnormality were at increased risk of 15-year mortality relative to their counterparts with no such abnormalities (adjusted hazard ratio = 1.80; 95% 1.41, 2.32). African and Native American ancestry levels had no significant effect modifying this association.Our findings indicate that African and Native American ancestry have no influence on the presence of major ECG abnormalities and had no influence on the ability of an ECG abnormality to predict mortality in older people infected with T. cruzi. In contrast, our results revealed a strong and independent association between prevalent T. cruzi infection and higher levels of African and Native American ancestry. Whether this association is a consequence of genetic background or differential exposure to infection remains to be determined. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 10 5 e0004724 |
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Directory of Open Access Journals: DOAJ Articles |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 M Fernanda Lima-Costa James Macinko Juliana Vaz de Mello Mambrini Sérgio Viana Peixoto Alexandre Costa Pereira Eduardo Tarazona-Santos Antonio Luiz Pinho Ribeiro Genomic African and Native American Ancestry and Chagas Disease: The Bambui (Brazil) Epigen Cohort Study of Aging. |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
The influence of genetic ancestry on Trypanosoma cruzi infection and Chagas disease outcomes is unknown.We used 370,539 Single Nucleotide Polymorphisms (SNPs) to examine the association between individual proportions of African, European and Native American genomic ancestry with T. cruzi infection and related outcomes in 1,341 participants (aged ≥ 60 years) of the Bambui (Brazil) population-based cohort study of aging. Potential confounding variables included sociodemographic characteristics and an array of health measures. The prevalence of T. cruzi infection was 37.5% and 56.3% of those infected had a major ECG abnormality. Baseline T. cruzi infection was correlated with higher levels of African and Native American ancestry, which in turn were strongly associated with poor socioeconomic circumstances. Cardiomyopathy in infected persons was not significantly associated with African or Native American ancestry levels. Infected persons with a major ECG abnormality were at increased risk of 15-year mortality relative to their counterparts with no such abnormalities (adjusted hazard ratio = 1.80; 95% 1.41, 2.32). African and Native American ancestry levels had no significant effect modifying this association.Our findings indicate that African and Native American ancestry have no influence on the presence of major ECG abnormalities and had no influence on the ability of an ECG abnormality to predict mortality in older people infected with T. cruzi. In contrast, our results revealed a strong and independent association between prevalent T. cruzi infection and higher levels of African and Native American ancestry. Whether this association is a consequence of genetic background or differential exposure to infection remains to be determined. |
format |
Article in Journal/Newspaper |
author |
M Fernanda Lima-Costa James Macinko Juliana Vaz de Mello Mambrini Sérgio Viana Peixoto Alexandre Costa Pereira Eduardo Tarazona-Santos Antonio Luiz Pinho Ribeiro |
author_facet |
M Fernanda Lima-Costa James Macinko Juliana Vaz de Mello Mambrini Sérgio Viana Peixoto Alexandre Costa Pereira Eduardo Tarazona-Santos Antonio Luiz Pinho Ribeiro |
author_sort |
M Fernanda Lima-Costa |
title |
Genomic African and Native American Ancestry and Chagas Disease: The Bambui (Brazil) Epigen Cohort Study of Aging. |
title_short |
Genomic African and Native American Ancestry and Chagas Disease: The Bambui (Brazil) Epigen Cohort Study of Aging. |
title_full |
Genomic African and Native American Ancestry and Chagas Disease: The Bambui (Brazil) Epigen Cohort Study of Aging. |
title_fullStr |
Genomic African and Native American Ancestry and Chagas Disease: The Bambui (Brazil) Epigen Cohort Study of Aging. |
title_full_unstemmed |
Genomic African and Native American Ancestry and Chagas Disease: The Bambui (Brazil) Epigen Cohort Study of Aging. |
title_sort |
genomic african and native american ancestry and chagas disease: the bambui (brazil) epigen cohort study of aging. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2016 |
url |
https://doi.org/10.1371/journal.pntd.0004724 https://doaj.org/article/402cd2a1ff7a4982b0611eb89a88a37e |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 10, Iss 5, p e0004724 (2016) |
op_relation |
http://europepmc.org/articles/PMC4868305?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004724 https://doaj.org/article/402cd2a1ff7a4982b0611eb89a88a37e |
op_doi |
https://doi.org/10.1371/journal.pntd.0004724 |
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PLOS Neglected Tropical Diseases |
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10 |
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5 |
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e0004724 |
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