Human papillomavirus genotypes in invasive cervical squamous cell carcinoma in Trinidad Genotipos de virus de los papilomas humanos en carcinoma cervicouterino escamocelular invasor en Trinidad
OBJECTIVE: To determine the relative contribution of known high-risk human papillomavirus (HPV) genotypes to the occurrence of cervical cancers in Trinidad. METHODS: The distribution of HPV genotypes in cases of invasive cervical squamous cell carcinoma in Trinidad was investigated. This study was a...
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Pan American Health Organization
2013
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ftdoajarticles:oai:doaj.org/article:3f888915f3f44f87b5a7286157b50122 2023-05-15T15:18:21+02:00 Human papillomavirus genotypes in invasive cervical squamous cell carcinoma in Trinidad Genotipos de virus de los papilomas humanos en carcinoma cervicouterino escamocelular invasor en Trinidad Felicia Hosein Wayne Mohammed Vanessa Zubach George Legall Alberto Severini 2013-04-01T00:00:00Z https://doaj.org/article/3f888915f3f44f87b5a7286157b50122 EN ES PT eng spa por Pan American Health Organization http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49892013000400005 https://doaj.org/toc/1020-4989 https://doaj.org/toc/1680-5348 1020-4989 1680-5348 https://doaj.org/article/3f888915f3f44f87b5a7286157b50122 Revista Panamericana de Salud Pública, Vol 33, Iss 4, Pp 267-270 (2013) Prevención de cáncer de cuello uterino Papillomaviridae región del Caribe Trinidad y Tobago Cervix neoplasms prevention Caribbean region Trinidad and Tobago Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2013 ftdoajarticles 2022-12-31T02:48:23Z OBJECTIVE: To determine the relative contribution of known high-risk human papillomavirus (HPV) genotypes to the occurrence of cervical cancers in Trinidad. METHODS: The distribution of HPV genotypes in cases of invasive cervical squamous cell carcinoma in Trinidad was investigated. This study was a follow-up to an investigation of HPV genotypes in 310 nonsymptomatic women in Trinidad. The latter study showed that cervical HPV prevalence and heterogeneity of genotypes were high in the study population; notably, the genotypes targeted by the available HPV prophylactic vaccines were not the most common types. RESULTS: The current study of 85 cases of invasive cervical squamous cell carcinomas demonstrated that the previously observed heterogeneity in HPV genotype distribution is lost in cases of invasive cervical cancer, with the vaccine-targeted HPV types HPV 16 and HPV 18 becoming the most prevalent. CONCLUSIONS: HPV 16 and HPV 18 were the primary HPV genotypes associated with cases of invasive squamous cell carcinoma in the current Trinidad study. This strong association leads us to conclude that the HPV vaccines targeting HPV 16 and HPV 18 may contribute to reducing the cervical cancer burden in Trinidad. OBJETIVO: Determinar la contribución relativa de los diferentes genotipos de virus de los papilomas humanos (VPH) conocidos como de alto riesgo para la aparición de cáncer cervicouterino en Trinidad. MÉTODOS: Se investigó la distribución de los genotipos de VPH en casos de carcinoma cervicouterino escamocelular invasor en Trinidad. Este estudio fue la continuación de una investigación de los genotipos de VPH presentes en 310 mujeres asintomáticas en Trinidad. Este último estudio reveló altas prevalencia de VPH en el cuello uterino y heterogeneidad de los genotipos en la población del estudio; cabe destacar que los genotipos a los que se dirigen las vacunas preventivas de la infección por VPH disponibles no fueron los tipos más frecuentes. RESULTADOS: El presente estudio, llevado a cabo en 85 casos de ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Trinidad ENVELOPE(-60.734,-60.734,-63.816,-63.816) |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English Spanish Portuguese |
topic |
Prevención de cáncer de cuello uterino Papillomaviridae región del Caribe Trinidad y Tobago Cervix neoplasms prevention Caribbean region Trinidad and Tobago Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Prevención de cáncer de cuello uterino Papillomaviridae región del Caribe Trinidad y Tobago Cervix neoplasms prevention Caribbean region Trinidad and Tobago Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Felicia Hosein Wayne Mohammed Vanessa Zubach George Legall Alberto Severini Human papillomavirus genotypes in invasive cervical squamous cell carcinoma in Trinidad Genotipos de virus de los papilomas humanos en carcinoma cervicouterino escamocelular invasor en Trinidad |
topic_facet |
Prevención de cáncer de cuello uterino Papillomaviridae región del Caribe Trinidad y Tobago Cervix neoplasms prevention Caribbean region Trinidad and Tobago Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
OBJECTIVE: To determine the relative contribution of known high-risk human papillomavirus (HPV) genotypes to the occurrence of cervical cancers in Trinidad. METHODS: The distribution of HPV genotypes in cases of invasive cervical squamous cell carcinoma in Trinidad was investigated. This study was a follow-up to an investigation of HPV genotypes in 310 nonsymptomatic women in Trinidad. The latter study showed that cervical HPV prevalence and heterogeneity of genotypes were high in the study population; notably, the genotypes targeted by the available HPV prophylactic vaccines were not the most common types. RESULTS: The current study of 85 cases of invasive cervical squamous cell carcinomas demonstrated that the previously observed heterogeneity in HPV genotype distribution is lost in cases of invasive cervical cancer, with the vaccine-targeted HPV types HPV 16 and HPV 18 becoming the most prevalent. CONCLUSIONS: HPV 16 and HPV 18 were the primary HPV genotypes associated with cases of invasive squamous cell carcinoma in the current Trinidad study. This strong association leads us to conclude that the HPV vaccines targeting HPV 16 and HPV 18 may contribute to reducing the cervical cancer burden in Trinidad. OBJETIVO: Determinar la contribución relativa de los diferentes genotipos de virus de los papilomas humanos (VPH) conocidos como de alto riesgo para la aparición de cáncer cervicouterino en Trinidad. MÉTODOS: Se investigó la distribución de los genotipos de VPH en casos de carcinoma cervicouterino escamocelular invasor en Trinidad. Este estudio fue la continuación de una investigación de los genotipos de VPH presentes en 310 mujeres asintomáticas en Trinidad. Este último estudio reveló altas prevalencia de VPH en el cuello uterino y heterogeneidad de los genotipos en la población del estudio; cabe destacar que los genotipos a los que se dirigen las vacunas preventivas de la infección por VPH disponibles no fueron los tipos más frecuentes. RESULTADOS: El presente estudio, llevado a cabo en 85 casos de ... |
format |
Article in Journal/Newspaper |
author |
Felicia Hosein Wayne Mohammed Vanessa Zubach George Legall Alberto Severini |
author_facet |
Felicia Hosein Wayne Mohammed Vanessa Zubach George Legall Alberto Severini |
author_sort |
Felicia Hosein |
title |
Human papillomavirus genotypes in invasive cervical squamous cell carcinoma in Trinidad Genotipos de virus de los papilomas humanos en carcinoma cervicouterino escamocelular invasor en Trinidad |
title_short |
Human papillomavirus genotypes in invasive cervical squamous cell carcinoma in Trinidad Genotipos de virus de los papilomas humanos en carcinoma cervicouterino escamocelular invasor en Trinidad |
title_full |
Human papillomavirus genotypes in invasive cervical squamous cell carcinoma in Trinidad Genotipos de virus de los papilomas humanos en carcinoma cervicouterino escamocelular invasor en Trinidad |
title_fullStr |
Human papillomavirus genotypes in invasive cervical squamous cell carcinoma in Trinidad Genotipos de virus de los papilomas humanos en carcinoma cervicouterino escamocelular invasor en Trinidad |
title_full_unstemmed |
Human papillomavirus genotypes in invasive cervical squamous cell carcinoma in Trinidad Genotipos de virus de los papilomas humanos en carcinoma cervicouterino escamocelular invasor en Trinidad |
title_sort |
human papillomavirus genotypes in invasive cervical squamous cell carcinoma in trinidad genotipos de virus de los papilomas humanos en carcinoma cervicouterino escamocelular invasor en trinidad |
publisher |
Pan American Health Organization |
publishDate |
2013 |
url |
https://doaj.org/article/3f888915f3f44f87b5a7286157b50122 |
long_lat |
ENVELOPE(-60.734,-60.734,-63.816,-63.816) |
geographic |
Arctic Trinidad |
geographic_facet |
Arctic Trinidad |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista Panamericana de Salud Pública, Vol 33, Iss 4, Pp 267-270 (2013) |
op_relation |
http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49892013000400005 https://doaj.org/toc/1020-4989 https://doaj.org/toc/1680-5348 1020-4989 1680-5348 https://doaj.org/article/3f888915f3f44f87b5a7286157b50122 |
_version_ |
1766348552401846272 |