Atorvastatin prevents Plasmodium falciparum cytoadherence and endothelial damage
Abstract Background The adhesion of Plasmodium falciparum parasitized red blood cell (PRBC) to human endothelial cells (EC) induces inflammatory processes, coagulation cascades, oxidative stress and apoptosis. These pathological processes are suspected to be responsible for the blood-brain-barrier a...
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ftdoajarticles:oai:doaj.org/article:3f5c0b28e03744ad9b071d4eae076310 2023-05-15T15:04:32+02:00 Atorvastatin prevents Plasmodium falciparum cytoadherence and endothelial damage Soubrier Florent Assi Serge Arrouss Issam N'dilimabaka Nadine Pino Paco Taoufiq Zacharie Rebollo Angelita Mazier Dominique 2011-02-01T00:00:00Z https://doi.org/10.1186/1475-2875-10-52 https://doaj.org/article/3f5c0b28e03744ad9b071d4eae076310 EN eng BMC http://www.malariajournal.com/content/10/1/52 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-10-52 1475-2875 https://doaj.org/article/3f5c0b28e03744ad9b071d4eae076310 Malaria Journal, Vol 10, Iss 1, p 52 (2011) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2011 ftdoajarticles https://doi.org/10.1186/1475-2875-10-52 2022-12-31T13:10:30Z Abstract Background The adhesion of Plasmodium falciparum parasitized red blood cell (PRBC) to human endothelial cells (EC) induces inflammatory processes, coagulation cascades, oxidative stress and apoptosis. These pathological processes are suspected to be responsible for the blood-brain-barrier and other organs' endothelial dysfunctions observed in fatal cases of malaria. Atorvastatin, a drug that belongs to the lowering cholesterol molecule family of statins, has been shown to ameliorate endothelial functions and is widely used in patients with cardiovascular disorders. Methods The effect of this compound on PRBC induced endothelial impairments was assessed using endothelial co-culture models. Results Atorvastatin pre-treatment of EC was found to reduce the expression of adhesion molecules and P. falciparum cytoadherence, to protect cells against PRBC-induced apoptosis and to enhance endothelial monolayer integrity during co-incubation with parasites. Conclusions These results might suggest a potential interest use of atorvastatin as a protective treatment to interfere with the pathophysiological cascades leading to severe malaria. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 10 1 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
topic |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Soubrier Florent Assi Serge Arrouss Issam N'dilimabaka Nadine Pino Paco Taoufiq Zacharie Rebollo Angelita Mazier Dominique Atorvastatin prevents Plasmodium falciparum cytoadherence and endothelial damage |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background The adhesion of Plasmodium falciparum parasitized red blood cell (PRBC) to human endothelial cells (EC) induces inflammatory processes, coagulation cascades, oxidative stress and apoptosis. These pathological processes are suspected to be responsible for the blood-brain-barrier and other organs' endothelial dysfunctions observed in fatal cases of malaria. Atorvastatin, a drug that belongs to the lowering cholesterol molecule family of statins, has been shown to ameliorate endothelial functions and is widely used in patients with cardiovascular disorders. Methods The effect of this compound on PRBC induced endothelial impairments was assessed using endothelial co-culture models. Results Atorvastatin pre-treatment of EC was found to reduce the expression of adhesion molecules and P. falciparum cytoadherence, to protect cells against PRBC-induced apoptosis and to enhance endothelial monolayer integrity during co-incubation with parasites. Conclusions These results might suggest a potential interest use of atorvastatin as a protective treatment to interfere with the pathophysiological cascades leading to severe malaria. |
format |
Article in Journal/Newspaper |
author |
Soubrier Florent Assi Serge Arrouss Issam N'dilimabaka Nadine Pino Paco Taoufiq Zacharie Rebollo Angelita Mazier Dominique |
author_facet |
Soubrier Florent Assi Serge Arrouss Issam N'dilimabaka Nadine Pino Paco Taoufiq Zacharie Rebollo Angelita Mazier Dominique |
author_sort |
Soubrier Florent |
title |
Atorvastatin prevents Plasmodium falciparum cytoadherence and endothelial damage |
title_short |
Atorvastatin prevents Plasmodium falciparum cytoadherence and endothelial damage |
title_full |
Atorvastatin prevents Plasmodium falciparum cytoadherence and endothelial damage |
title_fullStr |
Atorvastatin prevents Plasmodium falciparum cytoadherence and endothelial damage |
title_full_unstemmed |
Atorvastatin prevents Plasmodium falciparum cytoadherence and endothelial damage |
title_sort |
atorvastatin prevents plasmodium falciparum cytoadherence and endothelial damage |
publisher |
BMC |
publishDate |
2011 |
url |
https://doi.org/10.1186/1475-2875-10-52 https://doaj.org/article/3f5c0b28e03744ad9b071d4eae076310 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 10, Iss 1, p 52 (2011) |
op_relation |
http://www.malariajournal.com/content/10/1/52 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-10-52 1475-2875 https://doaj.org/article/3f5c0b28e03744ad9b071d4eae076310 |
op_doi |
https://doi.org/10.1186/1475-2875-10-52 |
container_title |
Malaria Journal |
container_volume |
10 |
container_issue |
1 |
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1766336287816548352 |