Bioinformatics Study of Sea Cucumber Peptides as Antibreast Cancer Through Inhibiting the Activity of Overexpressed Protein (EGFR, PI3K, AKT1, and CDK4)

• Published in: Cancer Informatics
• Main Authors: Teresa Liliana Wargasetia, Hana Ratnawati, Nashi Widodo, Muhammad Hermawan Widyananda
• Format: Article in Journal/Newspaper
• Language: English
• Published: SAGE Publishing 2021
• Subjects: Neoplasms. Tumors. Oncology. Including cancer and carcinogens; RC254-282; Vina; Cucumaria frondosa
• Online Access: https://doi.org/10.1177/11769351211031864; https://doaj.org/article/3f16fb981db0428bbc0779ce281e41dd

Breast cancer is the most common type of cancer in women globally. The overexpressed proteins, including EGFR, PI3K, AKT1, and CDK4, have a role in the growth of breast cancer cells. The 3D peptide structure of sea cucumber Cucumaria frondosa was modeled and then docked with EGFR, PI3K, AKT1, and CD...