Propolis modulates cellular biochemistry, antioxidants, cytokine profile, histological and ultra-morphological status against antituberculosis drugs induced hepatic injury
Objective: To evaluate hepatic injury induced by antituberculosis drugs (ATDs) when administered orally for 2, 4, 6 and 8 weeks and the therapeutic potential of propolis (bee hive product) against ATDs induced hepatic injury. Methods: The ATDs were administered for 8 weeks as well as propolis extrac...
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ftdoajarticles:oai:doaj.org/article:3e9b8686e8bc44c59b14c2ffd37171fb 2023-05-15T15:11:07+02:00 Propolis modulates cellular biochemistry, antioxidants, cytokine profile, histological and ultra-morphological status against antituberculosis drugs induced hepatic injury Nisha Sahu Gita Mishra Hemeshwer Kumar Chandra Satendra Kumar Nirala Monika Bhadauria 2018-01-01T00:00:00Z https://doi.org/10.4103/1995-7645.246337 https://doaj.org/article/3e9b8686e8bc44c59b14c2ffd37171fb EN eng Wolters Kluwer Medknow Publications http://www.apjtm.org/article.asp?issn=1995-7645;year=2018;volume=11;issue=11;spage=609;epage=620;aulast=Sahu https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.246337 https://doaj.org/article/3e9b8686e8bc44c59b14c2ffd37171fb Asian Pacific Journal of Tropical Medicine, Vol 11, Iss 11, Pp 609-620 (2018) antituberculosis drugs propolis biochemical hepatic injury Arctic medicine. Tropical medicine RC955-962 article 2018 ftdoajarticles https://doi.org/10.4103/1995-7645.246337 2022-12-31T05:38:54Z Objective: To evaluate hepatic injury induced by antituberculosis drugs (ATDs) when administered orally for 2, 4, 6 and 8 weeks and the therapeutic potential of propolis (bee hive product) against ATDs induced hepatic injury. Methods: The ATDs were administered for 8 weeks as well as propolis extract at three different doses (100, 200, 400 mg/kg) conjointly for 8 weeks in rats. Silymarin (50 mg/kg) was given as positive control. Animals were euthanized after 8 weeks; blood and liver samples were collected to perform various biochemicals, serological and histopathological and ultramorphological studies. Results: Significant increase (P < 0.05) in aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, triglyceride and cholesterol along with reduction in glucose and albumin level were noted after ATDs induced hepatic injury. Significant increase (P < 0.05) in lipid peroxidation, triglyceride, cholesterol and CYP2E1 activity; decline in reduced glutathione, catalase, superoxide dismutase, glutathione reductase, glutathione peroxidase, glucose-6-phosphatase dehydrogenase activity were observed after ATDs intoxication. Due to presence of a wide range of flavonoids and polyphenols in propolis extract, its administration reduced hepatic injury and maintained biochemical indices towards control. Histopathological and electron microscopic observations indicated hepatoprotective potential of propolis at cellular level whereas, TNF-α, IL-6 and IGF-1 confirmed therapeutic potential of propolis at molecular level. Conclusions: It can be concluded that propolis possess hepatoprotective potential against ATDs induced hepatic injury that may prove itself as a clinically useful natural product in management of drug induced liver injury. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Medicine 11 11 609 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
antituberculosis drugs propolis biochemical hepatic injury Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
antituberculosis drugs propolis biochemical hepatic injury Arctic medicine. Tropical medicine RC955-962 Nisha Sahu Gita Mishra Hemeshwer Kumar Chandra Satendra Kumar Nirala Monika Bhadauria Propolis modulates cellular biochemistry, antioxidants, cytokine profile, histological and ultra-morphological status against antituberculosis drugs induced hepatic injury |
topic_facet |
antituberculosis drugs propolis biochemical hepatic injury Arctic medicine. Tropical medicine RC955-962 |
description |
Objective: To evaluate hepatic injury induced by antituberculosis drugs (ATDs) when administered orally for 2, 4, 6 and 8 weeks and the therapeutic potential of propolis (bee hive product) against ATDs induced hepatic injury. Methods: The ATDs were administered for 8 weeks as well as propolis extract at three different doses (100, 200, 400 mg/kg) conjointly for 8 weeks in rats. Silymarin (50 mg/kg) was given as positive control. Animals were euthanized after 8 weeks; blood and liver samples were collected to perform various biochemicals, serological and histopathological and ultramorphological studies. Results: Significant increase (P < 0.05) in aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, triglyceride and cholesterol along with reduction in glucose and albumin level were noted after ATDs induced hepatic injury. Significant increase (P < 0.05) in lipid peroxidation, triglyceride, cholesterol and CYP2E1 activity; decline in reduced glutathione, catalase, superoxide dismutase, glutathione reductase, glutathione peroxidase, glucose-6-phosphatase dehydrogenase activity were observed after ATDs intoxication. Due to presence of a wide range of flavonoids and polyphenols in propolis extract, its administration reduced hepatic injury and maintained biochemical indices towards control. Histopathological and electron microscopic observations indicated hepatoprotective potential of propolis at cellular level whereas, TNF-α, IL-6 and IGF-1 confirmed therapeutic potential of propolis at molecular level. Conclusions: It can be concluded that propolis possess hepatoprotective potential against ATDs induced hepatic injury that may prove itself as a clinically useful natural product in management of drug induced liver injury. |
format |
Article in Journal/Newspaper |
author |
Nisha Sahu Gita Mishra Hemeshwer Kumar Chandra Satendra Kumar Nirala Monika Bhadauria |
author_facet |
Nisha Sahu Gita Mishra Hemeshwer Kumar Chandra Satendra Kumar Nirala Monika Bhadauria |
author_sort |
Nisha Sahu |
title |
Propolis modulates cellular biochemistry, antioxidants, cytokine profile, histological and ultra-morphological status against antituberculosis drugs induced hepatic injury |
title_short |
Propolis modulates cellular biochemistry, antioxidants, cytokine profile, histological and ultra-morphological status against antituberculosis drugs induced hepatic injury |
title_full |
Propolis modulates cellular biochemistry, antioxidants, cytokine profile, histological and ultra-morphological status against antituberculosis drugs induced hepatic injury |
title_fullStr |
Propolis modulates cellular biochemistry, antioxidants, cytokine profile, histological and ultra-morphological status against antituberculosis drugs induced hepatic injury |
title_full_unstemmed |
Propolis modulates cellular biochemistry, antioxidants, cytokine profile, histological and ultra-morphological status against antituberculosis drugs induced hepatic injury |
title_sort |
propolis modulates cellular biochemistry, antioxidants, cytokine profile, histological and ultra-morphological status against antituberculosis drugs induced hepatic injury |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2018 |
url |
https://doi.org/10.4103/1995-7645.246337 https://doaj.org/article/3e9b8686e8bc44c59b14c2ffd37171fb |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Medicine, Vol 11, Iss 11, Pp 609-620 (2018) |
op_relation |
http://www.apjtm.org/article.asp?issn=1995-7645;year=2018;volume=11;issue=11;spage=609;epage=620;aulast=Sahu https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.246337 https://doaj.org/article/3e9b8686e8bc44c59b14c2ffd37171fb |
op_doi |
https://doi.org/10.4103/1995-7645.246337 |
container_title |
Asian Pacific Journal of Tropical Medicine |
container_volume |
11 |
container_issue |
11 |
container_start_page |
609 |
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1766342023026049024 |