Composite Medicine “Azisal” Based on Azithromycin and Salicylic Acid
Salicylic acid essentially is obtained under the pressure by the method of Kolbe-Schmidt. One of the biggest drawbacks of this method is the necessity of synthesizing sodium phenolate in advance which involves considerable technological difficulties: water predistillation under vacuum and also the d...
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al-Farabi Kazakh National University
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ftdoajarticles:oai:doaj.org/article:3e6a4ee494064f86b651edc5842814a3 2023-05-15T15:52:59+02:00 Composite Medicine “Azisal” Based on Azithromycin and Salicylic Acid D. K. Kiyashev N. Shamshabanu M. D. Kiyashev M. K. Kamanova B. A. Ramazanova S. Sh. Shakiev G. M. Pichkhadze 2013-07-01T00:00:00Z https://doi.org/10.18321/ectj229 https://doaj.org/article/3e6a4ee494064f86b651edc5842814a3 EN eng al-Farabi Kazakh National University http://ect-journal.kz/index.php/ectj/article/view/333 https://doaj.org/toc/1562-3920 https://doaj.org/toc/2522-4867 1562-3920 2522-4867 doi:10.18321/ectj229 https://doaj.org/article/3e6a4ee494064f86b651edc5842814a3 Eurasian Chemico-Technological Journal, Vol 15, Iss 3, Pp 251-257 (2013) Chemistry QD1-999 article 2013 ftdoajarticles https://doi.org/10.18321/ectj229 2022-12-31T09:14:19Z Salicylic acid essentially is obtained under the pressure by the method of Kolbe-Schmidt. One of the biggest drawbacks of this method is the necessity of synthesizing sodium phenolate in advance which involves considerable technological difficulties: water predistillation under vacuum and also the dry sodium phenolate getting very hygroscopic. It is therefore of interest to look for more convenient alternative pathways for the synthesis of salicylic acid, excluding the use of sodium phenolate and this drawback is eliminated by using sodium and potassium salts of ethyl carbonic acid as carboxylation body. Consequently, according to the more convenient method we obtained the salicylic acid. In medicine, 1% solution of salicylic acid in 70 % alcohol called salicylic alcohol is used as an antiseptic. We investigated the antimicrobial activity of a 1% solution of salicylic acid in various concentrations of ethanol (40%, 50%, 60%, 70%, 80% and 90%) in order to determine the effect of different concentrations of ethanol on the antimicrobial activity of salicylic acid. The experiment proved that 1% solution of salicylic acid in various concentrations of ethanol (40-90%) to the appropriate strains of bacteria acts with the same activity regardless of the concentration of ethanol (40%, 50%, 60%, 70%, 80% and 90%). These actions of the acid are due to its solubility in alcohols of different concentrations and complete disintegration of salicylic acid molecules into ions. Thus, on the basis of antimicrobial research the necessity of preparation of 1% solution of salicylic acid in 40% alcohol is proved as the drug is cheaper and cost-effective to produce. The technology of the new composition of the drug “Azisal” consisting of 0.25 g azithromycin and 1.0 g salicylic acid in 60% ethanol was developed, in a similar way solution of azithromycin in different concentrations 0.25, 0.5, 0.75, 1.0% in 60% ethanol were prepared and their antimicrobial activities were defined. The comparison of their antimicrobial activity shows the ... Article in Journal/Newspaper Carbonic acid Directory of Open Access Journals: DOAJ Articles Eurasian Chemico-Technological Journal 15 3 251 |
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Chemistry QD1-999 |
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Chemistry QD1-999 D. K. Kiyashev N. Shamshabanu M. D. Kiyashev M. K. Kamanova B. A. Ramazanova S. Sh. Shakiev G. M. Pichkhadze Composite Medicine “Azisal” Based on Azithromycin and Salicylic Acid |
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Chemistry QD1-999 |
description |
Salicylic acid essentially is obtained under the pressure by the method of Kolbe-Schmidt. One of the biggest drawbacks of this method is the necessity of synthesizing sodium phenolate in advance which involves considerable technological difficulties: water predistillation under vacuum and also the dry sodium phenolate getting very hygroscopic. It is therefore of interest to look for more convenient alternative pathways for the synthesis of salicylic acid, excluding the use of sodium phenolate and this drawback is eliminated by using sodium and potassium salts of ethyl carbonic acid as carboxylation body. Consequently, according to the more convenient method we obtained the salicylic acid. In medicine, 1% solution of salicylic acid in 70 % alcohol called salicylic alcohol is used as an antiseptic. We investigated the antimicrobial activity of a 1% solution of salicylic acid in various concentrations of ethanol (40%, 50%, 60%, 70%, 80% and 90%) in order to determine the effect of different concentrations of ethanol on the antimicrobial activity of salicylic acid. The experiment proved that 1% solution of salicylic acid in various concentrations of ethanol (40-90%) to the appropriate strains of bacteria acts with the same activity regardless of the concentration of ethanol (40%, 50%, 60%, 70%, 80% and 90%). These actions of the acid are due to its solubility in alcohols of different concentrations and complete disintegration of salicylic acid molecules into ions. Thus, on the basis of antimicrobial research the necessity of preparation of 1% solution of salicylic acid in 40% alcohol is proved as the drug is cheaper and cost-effective to produce. The technology of the new composition of the drug “Azisal” consisting of 0.25 g azithromycin and 1.0 g salicylic acid in 60% ethanol was developed, in a similar way solution of azithromycin in different concentrations 0.25, 0.5, 0.75, 1.0% in 60% ethanol were prepared and their antimicrobial activities were defined. The comparison of their antimicrobial activity shows the ... |
format |
Article in Journal/Newspaper |
author |
D. K. Kiyashev N. Shamshabanu M. D. Kiyashev M. K. Kamanova B. A. Ramazanova S. Sh. Shakiev G. M. Pichkhadze |
author_facet |
D. K. Kiyashev N. Shamshabanu M. D. Kiyashev M. K. Kamanova B. A. Ramazanova S. Sh. Shakiev G. M. Pichkhadze |
author_sort |
D. K. Kiyashev |
title |
Composite Medicine “Azisal” Based on Azithromycin and Salicylic Acid |
title_short |
Composite Medicine “Azisal” Based on Azithromycin and Salicylic Acid |
title_full |
Composite Medicine “Azisal” Based on Azithromycin and Salicylic Acid |
title_fullStr |
Composite Medicine “Azisal” Based on Azithromycin and Salicylic Acid |
title_full_unstemmed |
Composite Medicine “Azisal” Based on Azithromycin and Salicylic Acid |
title_sort |
composite medicine “azisal” based on azithromycin and salicylic acid |
publisher |
al-Farabi Kazakh National University |
publishDate |
2013 |
url |
https://doi.org/10.18321/ectj229 https://doaj.org/article/3e6a4ee494064f86b651edc5842814a3 |
genre |
Carbonic acid |
genre_facet |
Carbonic acid |
op_source |
Eurasian Chemico-Technological Journal, Vol 15, Iss 3, Pp 251-257 (2013) |
op_relation |
http://ect-journal.kz/index.php/ectj/article/view/333 https://doaj.org/toc/1562-3920 https://doaj.org/toc/2522-4867 1562-3920 2522-4867 doi:10.18321/ectj229 https://doaj.org/article/3e6a4ee494064f86b651edc5842814a3 |
op_doi |
https://doi.org/10.18321/ectj229 |
container_title |
Eurasian Chemico-Technological Journal |
container_volume |
15 |
container_issue |
3 |
container_start_page |
251 |
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1766388060391473152 |