Reversible Audiometric Threshold Changes in Children with Uncomplicated Malaria
Background. Plasmodium falciparum malaria, as well as certain antimalarial drugs, is associated with hearing impairment in adults. There is little information, however, on the extent, if any, of this effect in children, and the evidence linking artemisinin combination therapies (ACTs) with hearing i...
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ftdoajarticles:oai:doaj.org/article:3e275cad6bd04115a30490d0dca1511c 2024-09-09T19:26:02+00:00 Reversible Audiometric Threshold Changes in Children with Uncomplicated Malaria George O. Adjei Bamenla Q. Goka Emmanuel Kitcher Onike P. Rodrigues Ebenezer Badoe Jorgen A. L. Kurtzhals 2013-01-01T00:00:00Z https://doi.org/10.1155/2013/360540 https://doaj.org/article/3e275cad6bd04115a30490d0dca1511c EN eng Wiley http://dx.doi.org/10.1155/2013/360540 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2013/360540 https://doaj.org/article/3e275cad6bd04115a30490d0dca1511c Journal of Tropical Medicine, Vol 2013 (2013) Arctic medicine. Tropical medicine RC955-962 article 2013 ftdoajarticles https://doi.org/10.1155/2013/360540 2024-08-05T17:48:43Z Background. Plasmodium falciparum malaria, as well as certain antimalarial drugs, is associated with hearing impairment in adults. There is little information, however, on the extent, if any, of this effect in children, and the evidence linking artemisinin combination therapies (ACTs) with hearing is inconclusive. Methods. Audiometry was conducted in children with uncomplicated malaria treated with artesunate-amodiaquine (n=37), artemether-lumefantrine (n=35), or amodiaquine (n=8) in Accra, Ghana. Audiometry was repeated 3, 7, and 28 days later and after 9 months. Audiometric thresholds were compared with those of a control group of children (n=57) from the same area. Findings. During the acute stage, hearing threshold levels of treated children were significantly elevated compared with controls (P<0.001). The threshold elevations persisted up to 28 days, but no differences in hearing thresholds were evident between treated children and controls after 9 months. The hearing thresholds of children treated with the two ACT regimens were comparable but lower than those of amodiaquine-treated children during acute illness. Interpretation. Malaria is the likely cause of the elevated hearing threshold levels during the acute illness, a finding that has implications for learning and development in areas of intense transmission, as well as for evaluating potential ototoxicity of new antimalarial drugs. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Tropical Medicine 2013 1 8 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
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English |
topic |
Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 George O. Adjei Bamenla Q. Goka Emmanuel Kitcher Onike P. Rodrigues Ebenezer Badoe Jorgen A. L. Kurtzhals Reversible Audiometric Threshold Changes in Children with Uncomplicated Malaria |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 |
description |
Background. Plasmodium falciparum malaria, as well as certain antimalarial drugs, is associated with hearing impairment in adults. There is little information, however, on the extent, if any, of this effect in children, and the evidence linking artemisinin combination therapies (ACTs) with hearing is inconclusive. Methods. Audiometry was conducted in children with uncomplicated malaria treated with artesunate-amodiaquine (n=37), artemether-lumefantrine (n=35), or amodiaquine (n=8) in Accra, Ghana. Audiometry was repeated 3, 7, and 28 days later and after 9 months. Audiometric thresholds were compared with those of a control group of children (n=57) from the same area. Findings. During the acute stage, hearing threshold levels of treated children were significantly elevated compared with controls (P<0.001). The threshold elevations persisted up to 28 days, but no differences in hearing thresholds were evident between treated children and controls after 9 months. The hearing thresholds of children treated with the two ACT regimens were comparable but lower than those of amodiaquine-treated children during acute illness. Interpretation. Malaria is the likely cause of the elevated hearing threshold levels during the acute illness, a finding that has implications for learning and development in areas of intense transmission, as well as for evaluating potential ototoxicity of new antimalarial drugs. |
format |
Article in Journal/Newspaper |
author |
George O. Adjei Bamenla Q. Goka Emmanuel Kitcher Onike P. Rodrigues Ebenezer Badoe Jorgen A. L. Kurtzhals |
author_facet |
George O. Adjei Bamenla Q. Goka Emmanuel Kitcher Onike P. Rodrigues Ebenezer Badoe Jorgen A. L. Kurtzhals |
author_sort |
George O. Adjei |
title |
Reversible Audiometric Threshold Changes in Children with Uncomplicated Malaria |
title_short |
Reversible Audiometric Threshold Changes in Children with Uncomplicated Malaria |
title_full |
Reversible Audiometric Threshold Changes in Children with Uncomplicated Malaria |
title_fullStr |
Reversible Audiometric Threshold Changes in Children with Uncomplicated Malaria |
title_full_unstemmed |
Reversible Audiometric Threshold Changes in Children with Uncomplicated Malaria |
title_sort |
reversible audiometric threshold changes in children with uncomplicated malaria |
publisher |
Wiley |
publishDate |
2013 |
url |
https://doi.org/10.1155/2013/360540 https://doaj.org/article/3e275cad6bd04115a30490d0dca1511c |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Tropical Medicine, Vol 2013 (2013) |
op_relation |
http://dx.doi.org/10.1155/2013/360540 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2013/360540 https://doaj.org/article/3e275cad6bd04115a30490d0dca1511c |
op_doi |
https://doi.org/10.1155/2013/360540 |
container_title |
Journal of Tropical Medicine |
container_volume |
2013 |
container_start_page |
1 |
op_container_end_page |
8 |
_version_ |
1809895735333748736 |