Plasmodium vivax resistance to chloroquine (R2) and mefloquine (R3) in Brazilian Amazon region Resistência do Plasmodium vivax pela cloroquina (R2) e mefloquina (R3) na amazônia Brasileira

• Published in: Revista da Sociedade Brasileira de Medicina Tropical
• Main Authors: Maria das Graças C. Alecrim, Wilson Alecrim, Vanize Macêdo
• Format: Article in Journal/Newspaper
• Language: English
• Published: Sociedade Brasileira de Medicina Tropical (SBMT) 1999
• Subjects: Plasmodium vivax; Resistência a drogas; Resistência à cloroquina; Resistência à mefloquina; Drug resistance; Chloroquine resistance; Mefloquine resistance; Arctic medicine. Tropical medicine; RC955-962; Arctic; Sob’
• Online Access: https://doi.org/10.1590/S0037-86821999000100013; https://doaj.org/article/3e0d6d10774b49b0935947ed258fa9ff

We report for the first time a patient with malaria due to Plasmodium vivax who showed R2 resistance to chloroquine and R3 resistance to mefloquine in the Brazilian Amazon region based on WHO clinical criteria for diagnosis of malaria resistance. Failure was observed with unsupervised oral chloroquine, chloroquine under rigorous supervision and mefloquine in the same scheme. Finally, the patient was cured with oral artesunate. Estamos relatando pela primeira vez um paciente com malária por Plasmodium vivax que mostrou resistência R2 à cloroquina e resistência R3 à mefloquina na Amazônia brasileira, de acordo com os critérios clínicos da OMS para resistência da malária. A falha foi observada com cloroquina oral, não supervisionada, cloroquina oral administrada sob rigorosa supervisão e com mefloquina no mesmo esquema. A paciente curou com o artesunato oral.