Epidemiology of malaria in an area prepared for clinical trials in Korogwe, north-eastern Tanzania
Abstract Background Site preparation is a pre-requesite in conducting malaria vaccines trials. This study was conducted in 12 villages to determine malariometric indices and associated risk factors, during long and short rainy seasons, in an area with varying malaria transmission intensities in Koro...
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ftdoajarticles:oai:doaj.org/article:3e0639cc4b624c54a6df6e6b1aeb16c5 2023-05-15T15:14:28+02:00 Epidemiology of malaria in an area prepared for clinical trials in Korogwe, north-eastern Tanzania Francis Filbert Seth Misago D Ishengoma Deus S Sembuche Samwel H Msangeni Hamisi A Segeja Method D Mmbando Bruno P Rutta Acleus S Kamugisha Mathias L Lemnge Martha M 2009-07-01T00:00:00Z https://doi.org/10.1186/1475-2875-8-165 https://doaj.org/article/3e0639cc4b624c54a6df6e6b1aeb16c5 EN eng BMC http://www.malariajournal.com/content/8/1/165 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-8-165 1475-2875 https://doaj.org/article/3e0639cc4b624c54a6df6e6b1aeb16c5 Malaria Journal, Vol 8, Iss 1, p 165 (2009) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2009 ftdoajarticles https://doi.org/10.1186/1475-2875-8-165 2022-12-31T00:39:31Z Abstract Background Site preparation is a pre-requesite in conducting malaria vaccines trials. This study was conducted in 12 villages to determine malariometric indices and associated risk factors, during long and short rainy seasons, in an area with varying malaria transmission intensities in Korogwe district, Tanzania. Four villages had passive case detection (PCD) of fever system using village health workers. Methods Four malariometric cross-sectional surveys were conducted between November 2005 and May 2007 among individuals aged 0–19 years, living in lowland urban, lowland rural and highland strata. A total of 10,766 blood samples were collected for malaria parasite diagnosis and anaemia estimation. Blood smears were stained with Giemsa while haemoglobin level was measured by HaemoCue. Socio-economic data were collected between Jan-Apr 2006. Results Adjusting for the effect of age, the risk of Plasmodium falciparum parasitaemia was significantly lower in both lowland urban, (OR = 0.26; 95%CI: 0.23–0.29, p < 0.001) and highlands, (OR = 0.21; 95%CI: 0.17–0.25, p < 0.001) compared to lowland rural. Individuals aged 6–9 years in the lowland rural and 4–19 years in both lowland urban and highlands had the highest parasite prevalence, whilst children below five years in all strata had the highest parasite density. Prevalence of splenomegaly and gametocyte were also lower in both lowland urban and highlands than in lowland rural. Anaemia (Hb <11 g/dl) prevalence was lowest in the lowland urban. Availability of PCD and higher socio-economic status (SES) were associated with reduced malaria and anaemia prevalence. Conclusion Higher SES and use of bed nets in the lowland urban could be the important factors for low malaria infections in this stratum. Results obtained here were used together with those from PCD and DSS in selecting a village for Phase 1b MSP3 vaccine trial, which was conducted in the study area in year 2008. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 8 1 |
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English |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Francis Filbert Seth Misago D Ishengoma Deus S Sembuche Samwel H Msangeni Hamisi A Segeja Method D Mmbando Bruno P Rutta Acleus S Kamugisha Mathias L Lemnge Martha M Epidemiology of malaria in an area prepared for clinical trials in Korogwe, north-eastern Tanzania |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Site preparation is a pre-requesite in conducting malaria vaccines trials. This study was conducted in 12 villages to determine malariometric indices and associated risk factors, during long and short rainy seasons, in an area with varying malaria transmission intensities in Korogwe district, Tanzania. Four villages had passive case detection (PCD) of fever system using village health workers. Methods Four malariometric cross-sectional surveys were conducted between November 2005 and May 2007 among individuals aged 0–19 years, living in lowland urban, lowland rural and highland strata. A total of 10,766 blood samples were collected for malaria parasite diagnosis and anaemia estimation. Blood smears were stained with Giemsa while haemoglobin level was measured by HaemoCue. Socio-economic data were collected between Jan-Apr 2006. Results Adjusting for the effect of age, the risk of Plasmodium falciparum parasitaemia was significantly lower in both lowland urban, (OR = 0.26; 95%CI: 0.23–0.29, p < 0.001) and highlands, (OR = 0.21; 95%CI: 0.17–0.25, p < 0.001) compared to lowland rural. Individuals aged 6–9 years in the lowland rural and 4–19 years in both lowland urban and highlands had the highest parasite prevalence, whilst children below five years in all strata had the highest parasite density. Prevalence of splenomegaly and gametocyte were also lower in both lowland urban and highlands than in lowland rural. Anaemia (Hb <11 g/dl) prevalence was lowest in the lowland urban. Availability of PCD and higher socio-economic status (SES) were associated with reduced malaria and anaemia prevalence. Conclusion Higher SES and use of bed nets in the lowland urban could be the important factors for low malaria infections in this stratum. Results obtained here were used together with those from PCD and DSS in selecting a village for Phase 1b MSP3 vaccine trial, which was conducted in the study area in year 2008. |
format |
Article in Journal/Newspaper |
author |
Francis Filbert Seth Misago D Ishengoma Deus S Sembuche Samwel H Msangeni Hamisi A Segeja Method D Mmbando Bruno P Rutta Acleus S Kamugisha Mathias L Lemnge Martha M |
author_facet |
Francis Filbert Seth Misago D Ishengoma Deus S Sembuche Samwel H Msangeni Hamisi A Segeja Method D Mmbando Bruno P Rutta Acleus S Kamugisha Mathias L Lemnge Martha M |
author_sort |
Francis Filbert |
title |
Epidemiology of malaria in an area prepared for clinical trials in Korogwe, north-eastern Tanzania |
title_short |
Epidemiology of malaria in an area prepared for clinical trials in Korogwe, north-eastern Tanzania |
title_full |
Epidemiology of malaria in an area prepared for clinical trials in Korogwe, north-eastern Tanzania |
title_fullStr |
Epidemiology of malaria in an area prepared for clinical trials in Korogwe, north-eastern Tanzania |
title_full_unstemmed |
Epidemiology of malaria in an area prepared for clinical trials in Korogwe, north-eastern Tanzania |
title_sort |
epidemiology of malaria in an area prepared for clinical trials in korogwe, north-eastern tanzania |
publisher |
BMC |
publishDate |
2009 |
url |
https://doi.org/10.1186/1475-2875-8-165 https://doaj.org/article/3e0639cc4b624c54a6df6e6b1aeb16c5 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 8, Iss 1, p 165 (2009) |
op_relation |
http://www.malariajournal.com/content/8/1/165 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-8-165 1475-2875 https://doaj.org/article/3e0639cc4b624c54a6df6e6b1aeb16c5 |
op_doi |
https://doi.org/10.1186/1475-2875-8-165 |
container_title |
Malaria Journal |
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8 |
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1 |
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1766344917802549248 |