Lives saved from malaria prevention in Africa--evidence to sustain cost-effective gains
Abstract Lives saved have become a standard metric to express health benefits across interventions and diseases. Recent estimates of malaria-attributable under-five deaths prevented using the Lives Saved tool (LiST), extrapolating effectiveness estimates from community-randomized trials of scale-up...
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ftdoajarticles:oai:doaj.org/article:3de8156f2e4b4c5a9f5dd6521e245038 2023-05-15T15:14:13+02:00 Lives saved from malaria prevention in Africa--evidence to sustain cost-effective gains Korenromp Eline L 2012-03-01T00:00:00Z https://doi.org/10.1186/1475-2875-11-94 https://doaj.org/article/3de8156f2e4b4c5a9f5dd6521e245038 EN eng BMC http://www.malariajournal.com/content/11/1/94 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-11-94 1475-2875 https://doaj.org/article/3de8156f2e4b4c5a9f5dd6521e245038 Malaria Journal, Vol 11, Iss 1, p 94 (2012) Malaria/economics Malaria/prevention and control Mortality Child Programme impact Programme evaluation Financing Health resources Investments Africa Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2012 ftdoajarticles https://doi.org/10.1186/1475-2875-11-94 2022-12-31T12:59:00Z Abstract Lives saved have become a standard metric to express health benefits across interventions and diseases. Recent estimates of malaria-attributable under-five deaths prevented using the Lives Saved tool (LiST), extrapolating effectiveness estimates from community-randomized trials of scale-up of insecticide-treated nets (ITNs) in the 1990s, confirm the substantial impact and good cost-effectiveness that ITNs have achieved in high-endemic sub-Saharan Africa. An even higher cost-effectiveness would likely have been found if the modelling had included the additional indirect mortality impact of ITNs on preventing deaths from other common child illnesses, to which malaria contributes as a risk factor. As conventional ITNs are being replaced by long-lasting insecticidal nets and scale-up is expanded to target universal coverage for full, all-age populations at risk, enhanced transmission reduction may--above certain thresholds--enhance the mortality impact beyond that observed in the trials of the 1990s. On the other hand, lives saved by ITNs might fall if improved malaria case management with artemisinin-based combination therapy averts the deaths that ITNs would otherwise prevent. Validation and updating of LiST's simple assumption of a universal, fixed coverage-to-mortality-reduction ratio will require enhanced national programme and impact monitoring and evaluation. Key indicators for time trend analysis include malaria-related mortality from population-based surveys and vital registration, vector control and treatment coverage from surveys, and parasitologically-confirmed malaria cases and deaths recorded in health facilities. Indispensable is triangulation with dynamic transmission models, fitted to long-term trend data on vector, parasite and human populations over successive phases of malaria control and elimination. Sound, locally optimized budget allocation including on monitoring and evaluation priorities will benefit much if policy makers and programme planners use planning tools such as LiST - even ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 11 1 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Malaria/economics Malaria/prevention and control Mortality Child Programme impact Programme evaluation Financing Health resources Investments Africa Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Malaria/economics Malaria/prevention and control Mortality Child Programme impact Programme evaluation Financing Health resources Investments Africa Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Korenromp Eline L Lives saved from malaria prevention in Africa--evidence to sustain cost-effective gains |
topic_facet |
Malaria/economics Malaria/prevention and control Mortality Child Programme impact Programme evaluation Financing Health resources Investments Africa Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Lives saved have become a standard metric to express health benefits across interventions and diseases. Recent estimates of malaria-attributable under-five deaths prevented using the Lives Saved tool (LiST), extrapolating effectiveness estimates from community-randomized trials of scale-up of insecticide-treated nets (ITNs) in the 1990s, confirm the substantial impact and good cost-effectiveness that ITNs have achieved in high-endemic sub-Saharan Africa. An even higher cost-effectiveness would likely have been found if the modelling had included the additional indirect mortality impact of ITNs on preventing deaths from other common child illnesses, to which malaria contributes as a risk factor. As conventional ITNs are being replaced by long-lasting insecticidal nets and scale-up is expanded to target universal coverage for full, all-age populations at risk, enhanced transmission reduction may--above certain thresholds--enhance the mortality impact beyond that observed in the trials of the 1990s. On the other hand, lives saved by ITNs might fall if improved malaria case management with artemisinin-based combination therapy averts the deaths that ITNs would otherwise prevent. Validation and updating of LiST's simple assumption of a universal, fixed coverage-to-mortality-reduction ratio will require enhanced national programme and impact monitoring and evaluation. Key indicators for time trend analysis include malaria-related mortality from population-based surveys and vital registration, vector control and treatment coverage from surveys, and parasitologically-confirmed malaria cases and deaths recorded in health facilities. Indispensable is triangulation with dynamic transmission models, fitted to long-term trend data on vector, parasite and human populations over successive phases of malaria control and elimination. Sound, locally optimized budget allocation including on monitoring and evaluation priorities will benefit much if policy makers and programme planners use planning tools such as LiST - even ... |
format |
Article in Journal/Newspaper |
author |
Korenromp Eline L |
author_facet |
Korenromp Eline L |
author_sort |
Korenromp Eline L |
title |
Lives saved from malaria prevention in Africa--evidence to sustain cost-effective gains |
title_short |
Lives saved from malaria prevention in Africa--evidence to sustain cost-effective gains |
title_full |
Lives saved from malaria prevention in Africa--evidence to sustain cost-effective gains |
title_fullStr |
Lives saved from malaria prevention in Africa--evidence to sustain cost-effective gains |
title_full_unstemmed |
Lives saved from malaria prevention in Africa--evidence to sustain cost-effective gains |
title_sort |
lives saved from malaria prevention in africa--evidence to sustain cost-effective gains |
publisher |
BMC |
publishDate |
2012 |
url |
https://doi.org/10.1186/1475-2875-11-94 https://doaj.org/article/3de8156f2e4b4c5a9f5dd6521e245038 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 11, Iss 1, p 94 (2012) |
op_relation |
http://www.malariajournal.com/content/11/1/94 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-11-94 1475-2875 https://doaj.org/article/3de8156f2e4b4c5a9f5dd6521e245038 |
op_doi |
https://doi.org/10.1186/1475-2875-11-94 |
container_title |
Malaria Journal |
container_volume |
11 |
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1 |
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1766344692816936960 |