Rationale for short course primaquine in Africa to interrupt malaria transmission
Abstract Following the recent successes of malaria control in sub-Saharan Africa, the gametocytocidal drug primaquine needs evaluation as a tool to further reduce the transmission of Plasmodium falciparum malaria. The drug has scarcely been used in Africa because of concerns about its safety in peop...
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ftdoajarticles:oai:doaj.org/article:3ddb581b29a24158bc70d5f5bc814a41 2023-05-15T15:11:30+02:00 Rationale for short course primaquine in Africa to interrupt malaria transmission Eziefula Alice C Gosling Roly Hwang Jimee Hsiang Michelle S Bousema Teun von Seidlein Lorenz Drakeley Chris 2012-10-01T00:00:00Z https://doi.org/10.1186/1475-2875-11-360 https://doaj.org/article/3ddb581b29a24158bc70d5f5bc814a41 EN eng BMC http://www.malariajournal.com/content/11/1/360 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-11-360 1475-2875 https://doaj.org/article/3ddb581b29a24158bc70d5f5bc814a41 Malaria Journal, Vol 11, Iss 1, p 360 (2012) Plasmodium falciparum Malaria Primaquine 8-aminoquinoline Transmission Gametocyte Glucose-6-phosphate dehydrogenase deficiency G6PD Africa Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2012 ftdoajarticles https://doi.org/10.1186/1475-2875-11-360 2022-12-30T21:45:34Z Abstract Following the recent successes of malaria control in sub-Saharan Africa, the gametocytocidal drug primaquine needs evaluation as a tool to further reduce the transmission of Plasmodium falciparum malaria. The drug has scarcely been used in Africa because of concerns about its safety in people with glucose-6-phosphate dehydrogenase (G6PD) deficiency. The evidence base for the use of primaquine as a transmission blocker is limited by a lack of comparable clinical and parasitological endpoints between trials. In March 2012, a group of experts met in London to discuss the existing evidence on the ability of primaquine to block malaria transmission, to define the roadblocks to the use of primaquine in Africa and to develop a roadmap to enable its rapid, safe and effective deployment. The output of this meeting is a strategic plan to optimize trial design to reach desired goals efficiently. The roadmap includes suggestions for a series of phase 1, 2, 3 and 4 studies to address specific hurdles to primaquine’s deployment. These include ex-vivo studies on efficacy, primaquine pharmacokinetics and pharmacodynamics and dose escalation studies for safety in high-risk groups. Phase 3 community trials are proposed, along with Phase 4 studies to evaluate safety, particularly in pregnancy, through pharmacovigilance in areas where primaquine is already deployed. In parallel, efforts need to be made to address issues in drug supply and regulation, to map G6PD deficiency and to support the evaluation of alternative gametocytocidal compounds. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 11 1 360 |
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English |
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Plasmodium falciparum Malaria Primaquine 8-aminoquinoline Transmission Gametocyte Glucose-6-phosphate dehydrogenase deficiency G6PD Africa Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Plasmodium falciparum Malaria Primaquine 8-aminoquinoline Transmission Gametocyte Glucose-6-phosphate dehydrogenase deficiency G6PD Africa Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Eziefula Alice C Gosling Roly Hwang Jimee Hsiang Michelle S Bousema Teun von Seidlein Lorenz Drakeley Chris Rationale for short course primaquine in Africa to interrupt malaria transmission |
topic_facet |
Plasmodium falciparum Malaria Primaquine 8-aminoquinoline Transmission Gametocyte Glucose-6-phosphate dehydrogenase deficiency G6PD Africa Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Following the recent successes of malaria control in sub-Saharan Africa, the gametocytocidal drug primaquine needs evaluation as a tool to further reduce the transmission of Plasmodium falciparum malaria. The drug has scarcely been used in Africa because of concerns about its safety in people with glucose-6-phosphate dehydrogenase (G6PD) deficiency. The evidence base for the use of primaquine as a transmission blocker is limited by a lack of comparable clinical and parasitological endpoints between trials. In March 2012, a group of experts met in London to discuss the existing evidence on the ability of primaquine to block malaria transmission, to define the roadblocks to the use of primaquine in Africa and to develop a roadmap to enable its rapid, safe and effective deployment. The output of this meeting is a strategic plan to optimize trial design to reach desired goals efficiently. The roadmap includes suggestions for a series of phase 1, 2, 3 and 4 studies to address specific hurdles to primaquine’s deployment. These include ex-vivo studies on efficacy, primaquine pharmacokinetics and pharmacodynamics and dose escalation studies for safety in high-risk groups. Phase 3 community trials are proposed, along with Phase 4 studies to evaluate safety, particularly in pregnancy, through pharmacovigilance in areas where primaquine is already deployed. In parallel, efforts need to be made to address issues in drug supply and regulation, to map G6PD deficiency and to support the evaluation of alternative gametocytocidal compounds. |
format |
Article in Journal/Newspaper |
author |
Eziefula Alice C Gosling Roly Hwang Jimee Hsiang Michelle S Bousema Teun von Seidlein Lorenz Drakeley Chris |
author_facet |
Eziefula Alice C Gosling Roly Hwang Jimee Hsiang Michelle S Bousema Teun von Seidlein Lorenz Drakeley Chris |
author_sort |
Eziefula Alice C |
title |
Rationale for short course primaquine in Africa to interrupt malaria transmission |
title_short |
Rationale for short course primaquine in Africa to interrupt malaria transmission |
title_full |
Rationale for short course primaquine in Africa to interrupt malaria transmission |
title_fullStr |
Rationale for short course primaquine in Africa to interrupt malaria transmission |
title_full_unstemmed |
Rationale for short course primaquine in Africa to interrupt malaria transmission |
title_sort |
rationale for short course primaquine in africa to interrupt malaria transmission |
publisher |
BMC |
publishDate |
2012 |
url |
https://doi.org/10.1186/1475-2875-11-360 https://doaj.org/article/3ddb581b29a24158bc70d5f5bc814a41 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 11, Iss 1, p 360 (2012) |
op_relation |
http://www.malariajournal.com/content/11/1/360 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-11-360 1475-2875 https://doaj.org/article/3ddb581b29a24158bc70d5f5bc814a41 |
op_doi |
https://doi.org/10.1186/1475-2875-11-360 |
container_title |
Malaria Journal |
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11 |
container_issue |
1 |
container_start_page |
360 |
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