THE COMPARATIVE STUDY OF EFFICACY AND TOLERABILITY OF GENERIC AND ORIGINAL VALSARTAN AS A MONOTHERAPY OR IN COMBINATION WITH HYDROCHLOROTHIAZIDE AND BISOPROLOL IN PATIENTS WITH ARTERIAL HYPERTENSION OF 1-2 DEGREE AND METABOLIC SYNDROME
Aim. To study the efficacy and safety of generic valsartan Valz (Actavis Group, Iceland) in comparison with the original valsartan Diovan® (Novartis, Switzerland) in patients with arterial hypertension (HT) of 1-2 degrees and metabolic syndrome. Material and Methods. 30 hypertensive patients (12 men...
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Столичная издательская компания
2015
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Online Access: | https://doi.org/10.1234/1819-6446-2012-1-17-22 https://doaj.org/article/3d972a433c3343c789115a62fc232cd3 |
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ftdoajarticles:oai:doaj.org/article:3d972a433c3343c789115a62fc232cd3 2023-10-01T03:56:59+02:00 THE COMPARATIVE STUDY OF EFFICACY AND TOLERABILITY OF GENERIC AND ORIGINAL VALSARTAN AS A MONOTHERAPY OR IN COMBINATION WITH HYDROCHLOROTHIAZIDE AND BISOPROLOL IN PATIENTS WITH ARTERIAL HYPERTENSION OF 1-2 DEGREE AND METABOLIC SYNDROME S. Yu. Martsevich Yu. V. Lukina N. A. Dmitrieva O. V. Lerman S. N. Tolpygina V. P. Voronina L. Yu. Drozdova 2015-12-01T00:00:00Z https://doi.org/10.1234/1819-6446-2012-1-17-22 https://doaj.org/article/3d972a433c3343c789115a62fc232cd3 EN RU eng rus Столичная издательская компания http://www.rpcardio.ru/jour/article/view/394 https://doaj.org/toc/1819-6446 https://doaj.org/toc/2225-3653 1819-6446 2225-3653 doi:10.1234/1819-6446-2012-1-17-22 https://doaj.org/article/3d972a433c3343c789115a62fc232cd3 Рациональная фармакотерапия в кардиологии, Vol 8, Iss 1, Pp 17-22 (2015) валсартан артериальная гипертония метаболический синдром комбинированная антигипертензивная терапия фиксированные комбинации Therapeutics. Pharmacology RM1-950 Diseases of the circulatory (Cardiovascular) system RC666-701 article 2015 ftdoajarticles https://doi.org/10.1234/1819-6446-2012-1-17-22 2023-09-03T00:40:52Z Aim. To study the efficacy and safety of generic valsartan Valz (Actavis Group, Iceland) in comparison with the original valsartan Diovan® (Novartis, Switzerland) in patients with arterial hypertension (HT) of 1-2 degrees and metabolic syndrome. Material and Methods. 30 hypertensive patients (12 men and 18 women) were enrolled in a randomized open-label crossover study. Each patient received generic and original valsartan (80 mg QD) sequentially during 8 weeks. When target blood pressure (BP) level (<130/80 mm Hg) was not reached, a fixed combination of valsartan with hydrochlorothiazide (80/12.5 mg, and then 160/12.5 mg), and bisoprolol 5 mg/daily , if necessary , were used. Treatment efficacy and safety was assessed at visit to doctor every 2 weeks throughout the study. The sequence of drug use was determined by randomization. Results. Systolic BP (SBP) decreased by 27.5 and 27.4 mm Hg from baseline due to generic and original valsartan 8 week treatment, respectively. Diastolic BP (DBP) decreased by 12.8 and 12.9 mm Hg , respectively (p>0.05). Target BP was achieved in 23 patients (77%) in both randomized groups. Serious adverse reaction were not observed during the treatment with both valsartan drugs. Conclusion. The therapeutic equivalence of generic and original valsartan drugs is shown. Therapy based on valsartan (in combination) was safe and effective in 77% of patients with HT of 1-2 degrees and metabolic syndrome. Article in Journal/Newspaper Iceland Directory of Open Access Journals: DOAJ Articles |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English Russian |
topic |
валсартан артериальная гипертония метаболический синдром комбинированная антигипертензивная терапия фиксированные комбинации Therapeutics. Pharmacology RM1-950 Diseases of the circulatory (Cardiovascular) system RC666-701 |
spellingShingle |
валсартан артериальная гипертония метаболический синдром комбинированная антигипертензивная терапия фиксированные комбинации Therapeutics. Pharmacology RM1-950 Diseases of the circulatory (Cardiovascular) system RC666-701 S. Yu. Martsevich Yu. V. Lukina N. A. Dmitrieva O. V. Lerman S. N. Tolpygina V. P. Voronina L. Yu. Drozdova THE COMPARATIVE STUDY OF EFFICACY AND TOLERABILITY OF GENERIC AND ORIGINAL VALSARTAN AS A MONOTHERAPY OR IN COMBINATION WITH HYDROCHLOROTHIAZIDE AND BISOPROLOL IN PATIENTS WITH ARTERIAL HYPERTENSION OF 1-2 DEGREE AND METABOLIC SYNDROME |
topic_facet |
валсартан артериальная гипертония метаболический синдром комбинированная антигипертензивная терапия фиксированные комбинации Therapeutics. Pharmacology RM1-950 Diseases of the circulatory (Cardiovascular) system RC666-701 |
description |
Aim. To study the efficacy and safety of generic valsartan Valz (Actavis Group, Iceland) in comparison with the original valsartan Diovan® (Novartis, Switzerland) in patients with arterial hypertension (HT) of 1-2 degrees and metabolic syndrome. Material and Methods. 30 hypertensive patients (12 men and 18 women) were enrolled in a randomized open-label crossover study. Each patient received generic and original valsartan (80 mg QD) sequentially during 8 weeks. When target blood pressure (BP) level (<130/80 mm Hg) was not reached, a fixed combination of valsartan with hydrochlorothiazide (80/12.5 mg, and then 160/12.5 mg), and bisoprolol 5 mg/daily , if necessary , were used. Treatment efficacy and safety was assessed at visit to doctor every 2 weeks throughout the study. The sequence of drug use was determined by randomization. Results. Systolic BP (SBP) decreased by 27.5 and 27.4 mm Hg from baseline due to generic and original valsartan 8 week treatment, respectively. Diastolic BP (DBP) decreased by 12.8 and 12.9 mm Hg , respectively (p>0.05). Target BP was achieved in 23 patients (77%) in both randomized groups. Serious adverse reaction were not observed during the treatment with both valsartan drugs. Conclusion. The therapeutic equivalence of generic and original valsartan drugs is shown. Therapy based on valsartan (in combination) was safe and effective in 77% of patients with HT of 1-2 degrees and metabolic syndrome. |
format |
Article in Journal/Newspaper |
author |
S. Yu. Martsevich Yu. V. Lukina N. A. Dmitrieva O. V. Lerman S. N. Tolpygina V. P. Voronina L. Yu. Drozdova |
author_facet |
S. Yu. Martsevich Yu. V. Lukina N. A. Dmitrieva O. V. Lerman S. N. Tolpygina V. P. Voronina L. Yu. Drozdova |
author_sort |
S. Yu. Martsevich |
title |
THE COMPARATIVE STUDY OF EFFICACY AND TOLERABILITY OF GENERIC AND ORIGINAL VALSARTAN AS A MONOTHERAPY OR IN COMBINATION WITH HYDROCHLOROTHIAZIDE AND BISOPROLOL IN PATIENTS WITH ARTERIAL HYPERTENSION OF 1-2 DEGREE AND METABOLIC SYNDROME |
title_short |
THE COMPARATIVE STUDY OF EFFICACY AND TOLERABILITY OF GENERIC AND ORIGINAL VALSARTAN AS A MONOTHERAPY OR IN COMBINATION WITH HYDROCHLOROTHIAZIDE AND BISOPROLOL IN PATIENTS WITH ARTERIAL HYPERTENSION OF 1-2 DEGREE AND METABOLIC SYNDROME |
title_full |
THE COMPARATIVE STUDY OF EFFICACY AND TOLERABILITY OF GENERIC AND ORIGINAL VALSARTAN AS A MONOTHERAPY OR IN COMBINATION WITH HYDROCHLOROTHIAZIDE AND BISOPROLOL IN PATIENTS WITH ARTERIAL HYPERTENSION OF 1-2 DEGREE AND METABOLIC SYNDROME |
title_fullStr |
THE COMPARATIVE STUDY OF EFFICACY AND TOLERABILITY OF GENERIC AND ORIGINAL VALSARTAN AS A MONOTHERAPY OR IN COMBINATION WITH HYDROCHLOROTHIAZIDE AND BISOPROLOL IN PATIENTS WITH ARTERIAL HYPERTENSION OF 1-2 DEGREE AND METABOLIC SYNDROME |
title_full_unstemmed |
THE COMPARATIVE STUDY OF EFFICACY AND TOLERABILITY OF GENERIC AND ORIGINAL VALSARTAN AS A MONOTHERAPY OR IN COMBINATION WITH HYDROCHLOROTHIAZIDE AND BISOPROLOL IN PATIENTS WITH ARTERIAL HYPERTENSION OF 1-2 DEGREE AND METABOLIC SYNDROME |
title_sort |
comparative study of efficacy and tolerability of generic and original valsartan as a monotherapy or in combination with hydrochlorothiazide and bisoprolol in patients with arterial hypertension of 1-2 degree and metabolic syndrome |
publisher |
Столичная издательская компания |
publishDate |
2015 |
url |
https://doi.org/10.1234/1819-6446-2012-1-17-22 https://doaj.org/article/3d972a433c3343c789115a62fc232cd3 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Рациональная фармакотерапия в кардиологии, Vol 8, Iss 1, Pp 17-22 (2015) |
op_relation |
http://www.rpcardio.ru/jour/article/view/394 https://doaj.org/toc/1819-6446 https://doaj.org/toc/2225-3653 1819-6446 2225-3653 doi:10.1234/1819-6446-2012-1-17-22 https://doaj.org/article/3d972a433c3343c789115a62fc232cd3 |
op_doi |
https://doi.org/10.1234/1819-6446-2012-1-17-22 |
_version_ |
1778527721961291776 |