Primary and booster vaccination with DTPw-HB/Hib pentavalent vaccine in Costa Rican children who had received a birth dose of hepatitis B vaccine
Objective. The DTPw-HB/Hib pentavalent combination vaccine has been developed following recommendations of the World Health Organization for the introduction of hepatitis B (HB) and Haemophilus influenzae type b (Hib) vaccines into routine childhood vaccination programs. The objectives of this study...
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Pan American Health Organization
2002
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ftdoajarticles:oai:doaj.org/article:3d4061ca29944d519b8fb8d9f234e2a6 2023-05-15T15:19:11+02:00 Primary and booster vaccination with DTPw-HB/Hib pentavalent vaccine in Costa Rican children who had received a birth dose of hepatitis B vaccine Idis Faingezicht Maria Luisa Avila-Aguerro Yolanda Cervantes Marc Fourneau Sue Ann Costa Clemens 2002-10-01T00:00:00Z https://doi.org/10.1590/s1020-49892002001000005 https://doaj.org/article/3d4061ca29944d519b8fb8d9f234e2a6 EN ES PT eng spa por Pan American Health Organization http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49892002001000005&lng=en&tlng=en https://doaj.org/toc/1020-4989 1020-4989 doi:10.1590/s1020-49892002001000005 https://doaj.org/article/3d4061ca29944d519b8fb8d9f234e2a6 Revista Panamericana de Salud Pública, Vol 12, Iss 4, Pp 247-257 (2002) Vaccination vaccines combined diphtheria-tetanus-pertussis vaccine Haemophilus influenzae hepatitis B Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2002 ftdoajarticles https://doi.org/10.1590/s1020-49892002001000005 2022-12-30T21:59:32Z Objective. The DTPw-HB/Hib pentavalent combination vaccine has been developed following recommendations of the World Health Organization for the introduction of hepatitis B (HB) and Haemophilus influenzae type b (Hib) vaccines into routine childhood vaccination programs. The objectives of this study were to: 1) analyze the immunogenicity and the reactogenicity of the DTPw-HB/Hib pentavalent combination vaccine in comparison to separate injections of DTPw-HB and Hib vaccines as primary vaccination in a group of children who had received a dose of HB vaccine at birth and 2) in the second year of life to assess the antibody persistence as well as the response to a DTPw-HB/Hib or DTPw/Hib booster. Methods. In the first part of the study (primary-vaccination stage), conducted in 1998-1999, we analyzed the immunogenicity and reactogenicity of the DTPw-HB/Hib combination vaccine in comparison to separate injections of DTPw-HB and Hib vaccines as primary vaccination at 2, 4, and 6 months of age in 207 Costa Rican children who had received a dose of HB vaccine at birth. Later, in the booster-vaccination stage of the study, in 1999-2000, in a subset of the children (69 toddlers, now 15-18 months old), antibody persistence was measured, and response to a DTPw-HB/Hib or DTPw/Hib booster was also assessed. Results. In both primary-vaccination groups, at least 97.5% of the infants reached protective levels of antibodies (seropositivity) against the antigens employed in the vaccines. The DTPw-HB/Hib pentavalent combination vaccine did not result in more local reactions than did the DTPw-HB vaccine alone, and, in terms of general reactions, there was no clinically significant difference between the combination or separate injections, and with the pentavalent vaccine having the benefit of needing one less injection. Nine months after the third dose of the primary-vaccination course, antibody persistence was similar in both groups, with over 93% of children still having protective/seropositive titers for Hib, HB, and tetanus and ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista Panamericana de Salud P�blica 12 4 |
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Vaccination vaccines combined diphtheria-tetanus-pertussis vaccine Haemophilus influenzae hepatitis B Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Vaccination vaccines combined diphtheria-tetanus-pertussis vaccine Haemophilus influenzae hepatitis B Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Idis Faingezicht Maria Luisa Avila-Aguerro Yolanda Cervantes Marc Fourneau Sue Ann Costa Clemens Primary and booster vaccination with DTPw-HB/Hib pentavalent vaccine in Costa Rican children who had received a birth dose of hepatitis B vaccine |
topic_facet |
Vaccination vaccines combined diphtheria-tetanus-pertussis vaccine Haemophilus influenzae hepatitis B Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Objective. The DTPw-HB/Hib pentavalent combination vaccine has been developed following recommendations of the World Health Organization for the introduction of hepatitis B (HB) and Haemophilus influenzae type b (Hib) vaccines into routine childhood vaccination programs. The objectives of this study were to: 1) analyze the immunogenicity and the reactogenicity of the DTPw-HB/Hib pentavalent combination vaccine in comparison to separate injections of DTPw-HB and Hib vaccines as primary vaccination in a group of children who had received a dose of HB vaccine at birth and 2) in the second year of life to assess the antibody persistence as well as the response to a DTPw-HB/Hib or DTPw/Hib booster. Methods. In the first part of the study (primary-vaccination stage), conducted in 1998-1999, we analyzed the immunogenicity and reactogenicity of the DTPw-HB/Hib combination vaccine in comparison to separate injections of DTPw-HB and Hib vaccines as primary vaccination at 2, 4, and 6 months of age in 207 Costa Rican children who had received a dose of HB vaccine at birth. Later, in the booster-vaccination stage of the study, in 1999-2000, in a subset of the children (69 toddlers, now 15-18 months old), antibody persistence was measured, and response to a DTPw-HB/Hib or DTPw/Hib booster was also assessed. Results. In both primary-vaccination groups, at least 97.5% of the infants reached protective levels of antibodies (seropositivity) against the antigens employed in the vaccines. The DTPw-HB/Hib pentavalent combination vaccine did not result in more local reactions than did the DTPw-HB vaccine alone, and, in terms of general reactions, there was no clinically significant difference between the combination or separate injections, and with the pentavalent vaccine having the benefit of needing one less injection. Nine months after the third dose of the primary-vaccination course, antibody persistence was similar in both groups, with over 93% of children still having protective/seropositive titers for Hib, HB, and tetanus and ... |
format |
Article in Journal/Newspaper |
author |
Idis Faingezicht Maria Luisa Avila-Aguerro Yolanda Cervantes Marc Fourneau Sue Ann Costa Clemens |
author_facet |
Idis Faingezicht Maria Luisa Avila-Aguerro Yolanda Cervantes Marc Fourneau Sue Ann Costa Clemens |
author_sort |
Idis Faingezicht |
title |
Primary and booster vaccination with DTPw-HB/Hib pentavalent vaccine in Costa Rican children who had received a birth dose of hepatitis B vaccine |
title_short |
Primary and booster vaccination with DTPw-HB/Hib pentavalent vaccine in Costa Rican children who had received a birth dose of hepatitis B vaccine |
title_full |
Primary and booster vaccination with DTPw-HB/Hib pentavalent vaccine in Costa Rican children who had received a birth dose of hepatitis B vaccine |
title_fullStr |
Primary and booster vaccination with DTPw-HB/Hib pentavalent vaccine in Costa Rican children who had received a birth dose of hepatitis B vaccine |
title_full_unstemmed |
Primary and booster vaccination with DTPw-HB/Hib pentavalent vaccine in Costa Rican children who had received a birth dose of hepatitis B vaccine |
title_sort |
primary and booster vaccination with dtpw-hb/hib pentavalent vaccine in costa rican children who had received a birth dose of hepatitis b vaccine |
publisher |
Pan American Health Organization |
publishDate |
2002 |
url |
https://doi.org/10.1590/s1020-49892002001000005 https://doaj.org/article/3d4061ca29944d519b8fb8d9f234e2a6 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista Panamericana de Salud Pública, Vol 12, Iss 4, Pp 247-257 (2002) |
op_relation |
http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49892002001000005&lng=en&tlng=en https://doaj.org/toc/1020-4989 1020-4989 doi:10.1590/s1020-49892002001000005 https://doaj.org/article/3d4061ca29944d519b8fb8d9f234e2a6 |
op_doi |
https://doi.org/10.1590/s1020-49892002001000005 |
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Revista Panamericana de Salud P�blica |
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12 |
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