Postepidemic analysis of Rift Valley fever virus transmission in northeastern kenya: a village cohort study.
In endemic areas, Rift Valley fever virus (RVFV) is a significant threat to both human and animal health. Goals of this study were to measure human anti-RVFV seroprevalence in a high-risk area following the 2006-2007 Kenyan Rift Valley Fever (RVF) epidemic, to identify risk factors for interval sero...
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ftdoajarticles:oai:doaj.org/article:3d3e9cafacbf4fd3b3eb920e8d239d1d 2023-05-15T15:15:20+02:00 Postepidemic analysis of Rift Valley fever virus transmission in northeastern kenya: a village cohort study. A Desirée LaBeaud Samuel Muiruri Laura J Sutherland Saidi Dahir Ginny Gildengorin John Morrill Eric M Muchiri Clarence J Peters Charles H King 2011-08-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0001265 https://doaj.org/article/3d3e9cafacbf4fd3b3eb920e8d239d1d EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3156691?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0001265 https://doaj.org/article/3d3e9cafacbf4fd3b3eb920e8d239d1d PLoS Neglected Tropical Diseases, Vol 5, Iss 8, p e1265 (2011) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2011 ftdoajarticles https://doi.org/10.1371/journal.pntd.0001265 2022-12-31T06:04:08Z In endemic areas, Rift Valley fever virus (RVFV) is a significant threat to both human and animal health. Goals of this study were to measure human anti-RVFV seroprevalence in a high-risk area following the 2006-2007 Kenyan Rift Valley Fever (RVF) epidemic, to identify risk factors for interval seroconversion, and to monitor individuals previously exposed to RVFV in order to document the persistence of their anti-RVFV antibodies.We conducted a village cohort study in Ijara District, Northeastern Province, Kenya. One hundred two individuals tested for RVFV exposure before the 2006-2007 RVF outbreak were restudied to determine interval anti-RVFV seroconversion and persistence of humoral immunity since 2006. Ninety-two additional subjects were enrolled from randomly selected households to help identify risk factors for current seropositivity. Overall, 44/194 or 23% (CI(95%):17%-29%) of local residents were RVFV seropositive. 1/85 at-risk individuals restudied in the follow-up cohort had seroconverted since early 2006. 27/92 (29%, CI(95%): 20%-39%) of newly tested individuals were seropositive. All 13 individuals with positive titers (by plaque reduction neutralization testing (PRNT₈₀) in 2006 remained positive in 2009. After adjustment in multivariable logistic models, age, village, and drinking raw milk were significantly associated with RVFV seropositivity. Visual impairment (defined as ≤ 20/80) was much more likely in the RVFV-seropositive group (P<0.0001).Our results highlight significant variability in RVFV exposure in two neighboring villages having very similar climate, terrain, and insect density. Among those with previous exposure, RVFV titers remained at > 1∶40 for more than 3 years. In concordance with previous studies, residents of the more rural village were more likely to be seropositive and RVFV seropositivity was associated with poor visual acuity. Raw milk consumption was strongly associated with RVFV exposure, which may represent an important new focus for public health education during ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 5 8 e1265 |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 A Desirée LaBeaud Samuel Muiruri Laura J Sutherland Saidi Dahir Ginny Gildengorin John Morrill Eric M Muchiri Clarence J Peters Charles H King Postepidemic analysis of Rift Valley fever virus transmission in northeastern kenya: a village cohort study. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
In endemic areas, Rift Valley fever virus (RVFV) is a significant threat to both human and animal health. Goals of this study were to measure human anti-RVFV seroprevalence in a high-risk area following the 2006-2007 Kenyan Rift Valley Fever (RVF) epidemic, to identify risk factors for interval seroconversion, and to monitor individuals previously exposed to RVFV in order to document the persistence of their anti-RVFV antibodies.We conducted a village cohort study in Ijara District, Northeastern Province, Kenya. One hundred two individuals tested for RVFV exposure before the 2006-2007 RVF outbreak were restudied to determine interval anti-RVFV seroconversion and persistence of humoral immunity since 2006. Ninety-two additional subjects were enrolled from randomly selected households to help identify risk factors for current seropositivity. Overall, 44/194 or 23% (CI(95%):17%-29%) of local residents were RVFV seropositive. 1/85 at-risk individuals restudied in the follow-up cohort had seroconverted since early 2006. 27/92 (29%, CI(95%): 20%-39%) of newly tested individuals were seropositive. All 13 individuals with positive titers (by plaque reduction neutralization testing (PRNT₈₀) in 2006 remained positive in 2009. After adjustment in multivariable logistic models, age, village, and drinking raw milk were significantly associated with RVFV seropositivity. Visual impairment (defined as ≤ 20/80) was much more likely in the RVFV-seropositive group (P<0.0001).Our results highlight significant variability in RVFV exposure in two neighboring villages having very similar climate, terrain, and insect density. Among those with previous exposure, RVFV titers remained at > 1∶40 for more than 3 years. In concordance with previous studies, residents of the more rural village were more likely to be seropositive and RVFV seropositivity was associated with poor visual acuity. Raw milk consumption was strongly associated with RVFV exposure, which may represent an important new focus for public health education during ... |
format |
Article in Journal/Newspaper |
author |
A Desirée LaBeaud Samuel Muiruri Laura J Sutherland Saidi Dahir Ginny Gildengorin John Morrill Eric M Muchiri Clarence J Peters Charles H King |
author_facet |
A Desirée LaBeaud Samuel Muiruri Laura J Sutherland Saidi Dahir Ginny Gildengorin John Morrill Eric M Muchiri Clarence J Peters Charles H King |
author_sort |
A Desirée LaBeaud |
title |
Postepidemic analysis of Rift Valley fever virus transmission in northeastern kenya: a village cohort study. |
title_short |
Postepidemic analysis of Rift Valley fever virus transmission in northeastern kenya: a village cohort study. |
title_full |
Postepidemic analysis of Rift Valley fever virus transmission in northeastern kenya: a village cohort study. |
title_fullStr |
Postepidemic analysis of Rift Valley fever virus transmission in northeastern kenya: a village cohort study. |
title_full_unstemmed |
Postepidemic analysis of Rift Valley fever virus transmission in northeastern kenya: a village cohort study. |
title_sort |
postepidemic analysis of rift valley fever virus transmission in northeastern kenya: a village cohort study. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2011 |
url |
https://doi.org/10.1371/journal.pntd.0001265 https://doaj.org/article/3d3e9cafacbf4fd3b3eb920e8d239d1d |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 5, Iss 8, p e1265 (2011) |
op_relation |
http://europepmc.org/articles/PMC3156691?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0001265 https://doaj.org/article/3d3e9cafacbf4fd3b3eb920e8d239d1d |
op_doi |
https://doi.org/10.1371/journal.pntd.0001265 |
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PLoS Neglected Tropical Diseases |
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5 |
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8 |
container_start_page |
e1265 |
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1766345688643272704 |