Syntheses of Benzo[ d ]Thiazol-2(3 H )-One Derivatives and Their Antidepressant and Anticonvulsant Effects
Thirty-four new benzo[ d ]thiazol derivatives 2a − 2i , 3a − 3r , and 4a − 4g were synthesized and investigated for their potential antidepressant and anticonvulsant effects. In a forced swimming test, 2c and 2d showed the highest antidepressant and anticonvulsant effects. 2c and 2d displayed a high...
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ftdoajarticles:oai:doaj.org/article:3cfba9414951408a8776b823ac29b506 2023-05-15T14:02:56+02:00 Syntheses of Benzo[ d ]Thiazol-2(3 H )-One Derivatives and Their Antidepressant and Anticonvulsant Effects Qinghao Jin Zhiyang Fu Liping Guan Haiying Jiang 2019-07-01T00:00:00Z https://doi.org/10.3390/md17070430 https://doaj.org/article/3cfba9414951408a8776b823ac29b506 EN eng MDPI AG https://www.mdpi.com/1660-3397/17/7/430 https://doaj.org/toc/1660-3397 1660-3397 doi:10.3390/md17070430 https://doaj.org/article/3cfba9414951408a8776b823ac29b506 Marine Drugs, Vol 17, Iss 7, p 430 (2019) benzo[ d ]thiazol synthesis antarctic-derived fungus antidepressant anticonvulsant Biology (General) QH301-705.5 article 2019 ftdoajarticles https://doi.org/10.3390/md17070430 2022-12-30T20:01:01Z Thirty-four new benzo[ d ]thiazol derivatives 2a − 2i , 3a − 3r , and 4a − 4g were synthesized and investigated for their potential antidepressant and anticonvulsant effects. In a forced swimming test, 2c and 2d showed the highest antidepressant and anticonvulsant effects. 2c and 2d displayed a higher percentage decrease in immobility duration (89.96% and 89.62%, respectively) than that of fluoxetine (83.62%). In the maximal electroshock seizure test, 3n and 3q showed the highest anticonvulsant effect, with ED 50 values of 46.1 and 64.3 mg kg − 1 , and protective indices of 6.34 and 4.11, respectively, which were similar to those of phenobarbital or valproate. We also found that the mechanism for the antidepressant activity of 2c and 2d may be via increasing the concentrations of serotonin and norepinephrine. Article in Journal/Newspaper Antarc* Antarctic Directory of Open Access Journals: DOAJ Articles Antarctic Marine Drugs 17 7 430 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
benzo[ d ]thiazol synthesis antarctic-derived fungus antidepressant anticonvulsant Biology (General) QH301-705.5 |
spellingShingle |
benzo[ d ]thiazol synthesis antarctic-derived fungus antidepressant anticonvulsant Biology (General) QH301-705.5 Qinghao Jin Zhiyang Fu Liping Guan Haiying Jiang Syntheses of Benzo[ d ]Thiazol-2(3 H )-One Derivatives and Their Antidepressant and Anticonvulsant Effects |
topic_facet |
benzo[ d ]thiazol synthesis antarctic-derived fungus antidepressant anticonvulsant Biology (General) QH301-705.5 |
description |
Thirty-four new benzo[ d ]thiazol derivatives 2a − 2i , 3a − 3r , and 4a − 4g were synthesized and investigated for their potential antidepressant and anticonvulsant effects. In a forced swimming test, 2c and 2d showed the highest antidepressant and anticonvulsant effects. 2c and 2d displayed a higher percentage decrease in immobility duration (89.96% and 89.62%, respectively) than that of fluoxetine (83.62%). In the maximal electroshock seizure test, 3n and 3q showed the highest anticonvulsant effect, with ED 50 values of 46.1 and 64.3 mg kg − 1 , and protective indices of 6.34 and 4.11, respectively, which were similar to those of phenobarbital or valproate. We also found that the mechanism for the antidepressant activity of 2c and 2d may be via increasing the concentrations of serotonin and norepinephrine. |
format |
Article in Journal/Newspaper |
author |
Qinghao Jin Zhiyang Fu Liping Guan Haiying Jiang |
author_facet |
Qinghao Jin Zhiyang Fu Liping Guan Haiying Jiang |
author_sort |
Qinghao Jin |
title |
Syntheses of Benzo[ d ]Thiazol-2(3 H )-One Derivatives and Their Antidepressant and Anticonvulsant Effects |
title_short |
Syntheses of Benzo[ d ]Thiazol-2(3 H )-One Derivatives and Their Antidepressant and Anticonvulsant Effects |
title_full |
Syntheses of Benzo[ d ]Thiazol-2(3 H )-One Derivatives and Their Antidepressant and Anticonvulsant Effects |
title_fullStr |
Syntheses of Benzo[ d ]Thiazol-2(3 H )-One Derivatives and Their Antidepressant and Anticonvulsant Effects |
title_full_unstemmed |
Syntheses of Benzo[ d ]Thiazol-2(3 H )-One Derivatives and Their Antidepressant and Anticonvulsant Effects |
title_sort |
syntheses of benzo[ d ]thiazol-2(3 h )-one derivatives and their antidepressant and anticonvulsant effects |
publisher |
MDPI AG |
publishDate |
2019 |
url |
https://doi.org/10.3390/md17070430 https://doaj.org/article/3cfba9414951408a8776b823ac29b506 |
geographic |
Antarctic |
geographic_facet |
Antarctic |
genre |
Antarc* Antarctic |
genre_facet |
Antarc* Antarctic |
op_source |
Marine Drugs, Vol 17, Iss 7, p 430 (2019) |
op_relation |
https://www.mdpi.com/1660-3397/17/7/430 https://doaj.org/toc/1660-3397 1660-3397 doi:10.3390/md17070430 https://doaj.org/article/3cfba9414951408a8776b823ac29b506 |
op_doi |
https://doi.org/10.3390/md17070430 |
container_title |
Marine Drugs |
container_volume |
17 |
container_issue |
7 |
container_start_page |
430 |
_version_ |
1766273390658715648 |