Spatial and Temporal Dynamics and Molecular Evolution of Tula orthohantavirus in German Vole Populations
Tula orthohantavirus (TULV) is a rodent-borne hantavirus with broad geographical distribution in Europe. Its major reservoir is the common vole ( Microtus arvalis ), but TULV has also been detected in closely related vole species. Given the large distributional range and high amplitude population dy...
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ftdoajarticles:oai:doaj.org/article:3ce99ac8a6334e48baf6603b22efd8da 2023-05-15T15:56:29+02:00 Spatial and Temporal Dynamics and Molecular Evolution of Tula orthohantavirus in German Vole Populations Sabrina Schmidt Daniela Reil Kathrin Jeske Stephan Drewes Ulrike M. Rosenfeld Stefan Fischer Nastasja G. Spierling Anton Labutin Gerald Heckel Jens Jacob Rainer G. Ulrich Christian Imholt 2021-06-01T00:00:00Z https://doi.org/10.3390/v13061132 https://doaj.org/article/3ce99ac8a6334e48baf6603b22efd8da EN eng MDPI AG https://www.mdpi.com/1999-4915/13/6/1132 https://doaj.org/toc/1999-4915 doi:10.3390/v13061132 1999-4915 https://doaj.org/article/3ce99ac8a6334e48baf6603b22efd8da Viruses, Vol 13, Iss 1132, p 1132 (2021) rodents hantavirus monitoring population dynamics common vole field vole Microbiology QR1-502 article 2021 ftdoajarticles https://doi.org/10.3390/v13061132 2022-12-31T09:06:11Z Tula orthohantavirus (TULV) is a rodent-borne hantavirus with broad geographical distribution in Europe. Its major reservoir is the common vole ( Microtus arvalis ), but TULV has also been detected in closely related vole species. Given the large distributional range and high amplitude population dynamics of common voles, this host–pathogen complex presents an ideal system to study the complex mechanisms of pathogen transmission in a wild rodent reservoir. We investigated the dynamics of TULV prevalence and the subsequent potential effects on the molecular evolution of TULV in common voles of the Central evolutionary lineage. Rodents were trapped for three years in four regions of Germany and samples were analyzed for the presence of TULV-reactive antibodies and TULV RNA with subsequent sequence determination. The results show that individual (sex) and population-level factors (abundance) of hosts were significant predictors of local TULV dynamics. At the large geographic scale, different phylogenetic TULV clades and an overall isolation-by-distance pattern in virus sequences were detected, while at the small scale (<4 km) this depended on the study area. In combination with an overall delayed density dependence, our results highlight that frequent, localized bottleneck events for the common vole and TULV do occur and can be offset by local recolonization dynamics. Article in Journal/Newspaper Common vole Microtus arvalis Directory of Open Access Journals: DOAJ Articles Tula ENVELOPE(-65.650,-65.650,-65.517,-65.517) Viruses 13 6 1132 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
rodents hantavirus monitoring population dynamics common vole field vole Microbiology QR1-502 |
spellingShingle |
rodents hantavirus monitoring population dynamics common vole field vole Microbiology QR1-502 Sabrina Schmidt Daniela Reil Kathrin Jeske Stephan Drewes Ulrike M. Rosenfeld Stefan Fischer Nastasja G. Spierling Anton Labutin Gerald Heckel Jens Jacob Rainer G. Ulrich Christian Imholt Spatial and Temporal Dynamics and Molecular Evolution of Tula orthohantavirus in German Vole Populations |
topic_facet |
rodents hantavirus monitoring population dynamics common vole field vole Microbiology QR1-502 |
description |
Tula orthohantavirus (TULV) is a rodent-borne hantavirus with broad geographical distribution in Europe. Its major reservoir is the common vole ( Microtus arvalis ), but TULV has also been detected in closely related vole species. Given the large distributional range and high amplitude population dynamics of common voles, this host–pathogen complex presents an ideal system to study the complex mechanisms of pathogen transmission in a wild rodent reservoir. We investigated the dynamics of TULV prevalence and the subsequent potential effects on the molecular evolution of TULV in common voles of the Central evolutionary lineage. Rodents were trapped for three years in four regions of Germany and samples were analyzed for the presence of TULV-reactive antibodies and TULV RNA with subsequent sequence determination. The results show that individual (sex) and population-level factors (abundance) of hosts were significant predictors of local TULV dynamics. At the large geographic scale, different phylogenetic TULV clades and an overall isolation-by-distance pattern in virus sequences were detected, while at the small scale (<4 km) this depended on the study area. In combination with an overall delayed density dependence, our results highlight that frequent, localized bottleneck events for the common vole and TULV do occur and can be offset by local recolonization dynamics. |
format |
Article in Journal/Newspaper |
author |
Sabrina Schmidt Daniela Reil Kathrin Jeske Stephan Drewes Ulrike M. Rosenfeld Stefan Fischer Nastasja G. Spierling Anton Labutin Gerald Heckel Jens Jacob Rainer G. Ulrich Christian Imholt |
author_facet |
Sabrina Schmidt Daniela Reil Kathrin Jeske Stephan Drewes Ulrike M. Rosenfeld Stefan Fischer Nastasja G. Spierling Anton Labutin Gerald Heckel Jens Jacob Rainer G. Ulrich Christian Imholt |
author_sort |
Sabrina Schmidt |
title |
Spatial and Temporal Dynamics and Molecular Evolution of Tula orthohantavirus in German Vole Populations |
title_short |
Spatial and Temporal Dynamics and Molecular Evolution of Tula orthohantavirus in German Vole Populations |
title_full |
Spatial and Temporal Dynamics and Molecular Evolution of Tula orthohantavirus in German Vole Populations |
title_fullStr |
Spatial and Temporal Dynamics and Molecular Evolution of Tula orthohantavirus in German Vole Populations |
title_full_unstemmed |
Spatial and Temporal Dynamics and Molecular Evolution of Tula orthohantavirus in German Vole Populations |
title_sort |
spatial and temporal dynamics and molecular evolution of tula orthohantavirus in german vole populations |
publisher |
MDPI AG |
publishDate |
2021 |
url |
https://doi.org/10.3390/v13061132 https://doaj.org/article/3ce99ac8a6334e48baf6603b22efd8da |
long_lat |
ENVELOPE(-65.650,-65.650,-65.517,-65.517) |
geographic |
Tula |
geographic_facet |
Tula |
genre |
Common vole Microtus arvalis |
genre_facet |
Common vole Microtus arvalis |
op_source |
Viruses, Vol 13, Iss 1132, p 1132 (2021) |
op_relation |
https://www.mdpi.com/1999-4915/13/6/1132 https://doaj.org/toc/1999-4915 doi:10.3390/v13061132 1999-4915 https://doaj.org/article/3ce99ac8a6334e48baf6603b22efd8da |
op_doi |
https://doi.org/10.3390/v13061132 |
container_title |
Viruses |
container_volume |
13 |
container_issue |
6 |
container_start_page |
1132 |
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1766391893748350976 |