Primary Motor Cortex Representation of Handgrip Muscles in Patients with Leprosy.
Leprosy is an endemic infectious disease caused by Mycobacterium leprae that predominantly attacks the skin and peripheral nerves, leading to progressive impairment of motor, sensory and autonomic function. Little is known about how this peripheral neuropathy affects corticospinal excitability of ha...
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ftdoajarticles:oai:doaj.org/article:3cdff866b3fe4d0d96c9d5559fa49e0b 2023-05-15T15:15:02+02:00 Primary Motor Cortex Representation of Handgrip Muscles in Patients with Leprosy. Vagner Wilian Batista E Sá Maria Katia Gomes Maria Luíza Sales Rangel Tiago Arruda Sanchez Filipe Azaline Moreira Sebastian Hoefle Inaiacy Bittencourt Souto Antônio José Ledo Alves da Cunha Ana Paula Fontana Claudia Domingues Vargas 2015-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0003944 https://doaj.org/article/3cdff866b3fe4d0d96c9d5559fa49e0b EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4512691?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003944 https://doaj.org/article/3cdff866b3fe4d0d96c9d5559fa49e0b PLoS Neglected Tropical Diseases, Vol 9, Iss 7, p e0003944 (2015) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2015 ftdoajarticles https://doi.org/10.1371/journal.pntd.0003944 2023-01-08T01:27:25Z Leprosy is an endemic infectious disease caused by Mycobacterium leprae that predominantly attacks the skin and peripheral nerves, leading to progressive impairment of motor, sensory and autonomic function. Little is known about how this peripheral neuropathy affects corticospinal excitability of handgrip muscles. Our purpose was to explore the motor cortex organization after progressive peripheral nerve injury and upper-limb dysfunction induced by leprosy using noninvasive transcranial magnetic stimulation (TMS).In a cross-sectional study design, we mapped bilaterally in the primary motor cortex (M1) the representations of the hand flexor digitorum superficialis (FDS), as well as of the intrinsic hand muscles abductor pollicis brevis (APB), first dorsal interosseous (FDI) and abductor digiti minimi (ADM). All participants underwent clinical assessment, handgrip dynamometry and motor and sensory nerve conduction exams 30 days before mapping. Wilcoxon signed rank and Mann-Whitney tests were performed with an alpha-value of p<0.05.Dynamometry performance of the patients' most affected hand (MAH), was worse than that of the less affected hand (LAH) and of healthy controls participants (p = 0.031), confirming handgrip impairment. Motor threshold (MT) of the FDS muscle was higher in both hemispheres in patients as compared to controls, and lower in the hemisphere contralateral to the MAH when compared to that of the LAH. Moreover, motor evoked potential (MEP) amplitudes collected in the FDS of the MAH were higher in comparison to those of controls. Strikingly, MEPs in the intrinsic hand muscle FDI had lower amplitudes in the hemisphere contralateral to MAH as compared to those of the LAH and the control group. Taken together, these results are suggestive of a more robust representation of an extrinsic hand flexor and impaired intrinsic hand muscle function in the hemisphere contralateral to the MAH due to leprosy.Decreased sensory-motor function induced by leprosy affects handgrip muscle representation in M1. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 9 7 e0003944 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Vagner Wilian Batista E Sá Maria Katia Gomes Maria Luíza Sales Rangel Tiago Arruda Sanchez Filipe Azaline Moreira Sebastian Hoefle Inaiacy Bittencourt Souto Antônio José Ledo Alves da Cunha Ana Paula Fontana Claudia Domingues Vargas Primary Motor Cortex Representation of Handgrip Muscles in Patients with Leprosy. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Leprosy is an endemic infectious disease caused by Mycobacterium leprae that predominantly attacks the skin and peripheral nerves, leading to progressive impairment of motor, sensory and autonomic function. Little is known about how this peripheral neuropathy affects corticospinal excitability of handgrip muscles. Our purpose was to explore the motor cortex organization after progressive peripheral nerve injury and upper-limb dysfunction induced by leprosy using noninvasive transcranial magnetic stimulation (TMS).In a cross-sectional study design, we mapped bilaterally in the primary motor cortex (M1) the representations of the hand flexor digitorum superficialis (FDS), as well as of the intrinsic hand muscles abductor pollicis brevis (APB), first dorsal interosseous (FDI) and abductor digiti minimi (ADM). All participants underwent clinical assessment, handgrip dynamometry and motor and sensory nerve conduction exams 30 days before mapping. Wilcoxon signed rank and Mann-Whitney tests were performed with an alpha-value of p<0.05.Dynamometry performance of the patients' most affected hand (MAH), was worse than that of the less affected hand (LAH) and of healthy controls participants (p = 0.031), confirming handgrip impairment. Motor threshold (MT) of the FDS muscle was higher in both hemispheres in patients as compared to controls, and lower in the hemisphere contralateral to the MAH when compared to that of the LAH. Moreover, motor evoked potential (MEP) amplitudes collected in the FDS of the MAH were higher in comparison to those of controls. Strikingly, MEPs in the intrinsic hand muscle FDI had lower amplitudes in the hemisphere contralateral to MAH as compared to those of the LAH and the control group. Taken together, these results are suggestive of a more robust representation of an extrinsic hand flexor and impaired intrinsic hand muscle function in the hemisphere contralateral to the MAH due to leprosy.Decreased sensory-motor function induced by leprosy affects handgrip muscle representation in M1. |
format |
Article in Journal/Newspaper |
author |
Vagner Wilian Batista E Sá Maria Katia Gomes Maria Luíza Sales Rangel Tiago Arruda Sanchez Filipe Azaline Moreira Sebastian Hoefle Inaiacy Bittencourt Souto Antônio José Ledo Alves da Cunha Ana Paula Fontana Claudia Domingues Vargas |
author_facet |
Vagner Wilian Batista E Sá Maria Katia Gomes Maria Luíza Sales Rangel Tiago Arruda Sanchez Filipe Azaline Moreira Sebastian Hoefle Inaiacy Bittencourt Souto Antônio José Ledo Alves da Cunha Ana Paula Fontana Claudia Domingues Vargas |
author_sort |
Vagner Wilian Batista E Sá |
title |
Primary Motor Cortex Representation of Handgrip Muscles in Patients with Leprosy. |
title_short |
Primary Motor Cortex Representation of Handgrip Muscles in Patients with Leprosy. |
title_full |
Primary Motor Cortex Representation of Handgrip Muscles in Patients with Leprosy. |
title_fullStr |
Primary Motor Cortex Representation of Handgrip Muscles in Patients with Leprosy. |
title_full_unstemmed |
Primary Motor Cortex Representation of Handgrip Muscles in Patients with Leprosy. |
title_sort |
primary motor cortex representation of handgrip muscles in patients with leprosy. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2015 |
url |
https://doi.org/10.1371/journal.pntd.0003944 https://doaj.org/article/3cdff866b3fe4d0d96c9d5559fa49e0b |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 9, Iss 7, p e0003944 (2015) |
op_relation |
http://europepmc.org/articles/PMC4512691?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003944 https://doaj.org/article/3cdff866b3fe4d0d96c9d5559fa49e0b |
op_doi |
https://doi.org/10.1371/journal.pntd.0003944 |
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PLOS Neglected Tropical Diseases |
container_volume |
9 |
container_issue |
7 |
container_start_page |
e0003944 |
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