Sucrose concentration and pH in liquid oral pediatric medicines of long-term use for children Concentración de sacarosa y pH en medicamentos líquidos pediátricos para uso a largo plazo por vía oral

• Main Authors: Isabela Albuquerque Passos, Fábio Correia Sampaio, Cosme Rafael Martínez, Cláudia Helena Soares de Morais Freitas
• Format: Article in Journal/Newspaper
• Language: English; Spanish; Portuguese
• Published: Pan American Health Organization 2010
• Subjects: Sacarosa; concentración de iones hidrógeno; niño; preescolar; caries dental; erosión de los dientes; Brasil; Sucrose; hydrogen-ion concentration; child; preschool; dental caries; tooth erosion; Brazil; Medicine; R; Arctic medicine. Tropical medicine; RC955-962; Public aspects of medicine; RA1-1270; Arctic; Los Dientes
• Online Access: https://doaj.org/article/3cdf2e8a8fdf4ff29072c2a99e493429

OBJECTIVES: To determine the pH and sucrose concentrations (SC) of pediatric liquid drugs of long-term use by children in order to evaluate the potential risk for dental caries and dental erosion. METHODS: After assessing the pH, we analyzed 71 aqueous medicine samples for sucrose by the Lane-Eynon general volumetric method. The pH and SC values (mean ± standard deviation (SD) were calculated according to therapeutic action. RESULTS: The highest and the lowest SC values (mean ± SD) were found in respiratory (37.75% ± 17.23%) and endocrine drugs (11.97% ± 15.16%) (p < 0.01). The values for medicines prescribed for daily ingestion were 47.15% ± 9.57%, whereas for twice daily and three or four times a day, these numbers were 24.42% ± 18.03% and 34.43% ± 14.83%, respectively (p < 0.01). The SC (mean ± SD)) values were higher in syrups (36.32% ± 17.62%) than in other formulations (p > 0.05). The overall pH (mean ± SD) was 5.89 ± 2.02 (range 2.3 ± 0.01 to 10.6 ± 0.02). In products with acidic pH, the SC (mean ± SD) was significantly lower (22.14% ± 15.72%) than in nonacidic medicines (39.22% ± 15.82%) (p < 0.001). CONCLUSIONS: It can be concluded that the pediatric medicines studied have a high SC and low pH, which vary according to therapeutic class, daily dose, and brand. Caution about dental caries, dental erosion, and systemic diseases such as diabetes mellitus is warranted when these medicines are ingested frequently. OBJETIVOS: Determinar el pH y las concentraciones de sacarosa de medicamentos pediátricos líquidos de uso oral a largo plazo, para evaluar el riesgo potencial de caries y erosión dental. MÉTODOS: Se analizaron 71 muestras de medicamentos líquidos; después de evaluar el pH, se determinó la sacarosa por el método volumétrico de Lane&Eynon. El pH y los valores de sacarosa (media ± desviación estándar [DE]) se calcularon de acuerdo con la acción terapéutica. RESULTADOS: El valor de sacarosa más alto (media ± DE) se encontró en los medicamentos respiratorios (37,75% ± 17,23%) y el más ...