The first high-density genetic map of common cockle (Cerastoderma edule) reveals a major QTL controlling shell color variation
Abstract Shell color shows broad variation within mollusc species and despite information on the genetic pathways involved in shell construction and color has recently increased, more studies are needed to understand its genetic architecture. The common cockle (Cerastoderma edule) is a valuable spec...
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ftdoajarticles:oai:doaj.org/article:3cd9ed04952b412d86527410ec29df43 2023-05-15T17:41:29+02:00 The first high-density genetic map of common cockle (Cerastoderma edule) reveals a major QTL controlling shell color variation Miguel Hermida Diego Robledo Seila Díaz Damián Costas Alicia L. Bruzos Andrés Blanco Belén G. Pardo Paulino Martínez 2022-10-01T00:00:00Z https://doi.org/10.1038/s41598-022-21214-3 https://doaj.org/article/3cd9ed04952b412d86527410ec29df43 EN eng Nature Portfolio https://doi.org/10.1038/s41598-022-21214-3 https://doaj.org/toc/2045-2322 doi:10.1038/s41598-022-21214-3 2045-2322 https://doaj.org/article/3cd9ed04952b412d86527410ec29df43 Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022) Medicine R Science Q article 2022 ftdoajarticles https://doi.org/10.1038/s41598-022-21214-3 2022-12-30T20:31:31Z Abstract Shell color shows broad variation within mollusc species and despite information on the genetic pathways involved in shell construction and color has recently increased, more studies are needed to understand its genetic architecture. The common cockle (Cerastoderma edule) is a valuable species from ecological and commercial perspectives which shows important variation in shell color across Northeast Atlantic. In this study, we constructed a high-density genetic map, as a tool for screening common cockle genome, which was applied to ascertain the genetic basis of color variation in the species. The consensus genetic map comprised 19 linkage groups (LGs) in accordance with the cockle karyotype (2n = 38) and spanned 1073 cM, including 730 markers per LG and an inter-marker distance of 0.13 cM. Five full-sib families showing segregation for several color-associated traits were used for a genome-wide association study and a major QTL on chromosome 13 associated to different color-traits was detected. Mining on this genomic region revealed several candidate genes related to shell construction and color. A genomic region previously reported associated with divergent selection in cockle distribution overlapped with this QTL suggesting its putative role on adaptation. Article in Journal/Newspaper Northeast Atlantic Directory of Open Access Journals: DOAJ Articles Scientific Reports 12 1 |
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Medicine R Science Q Miguel Hermida Diego Robledo Seila Díaz Damián Costas Alicia L. Bruzos Andrés Blanco Belén G. Pardo Paulino Martínez The first high-density genetic map of common cockle (Cerastoderma edule) reveals a major QTL controlling shell color variation |
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Medicine R Science Q |
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Abstract Shell color shows broad variation within mollusc species and despite information on the genetic pathways involved in shell construction and color has recently increased, more studies are needed to understand its genetic architecture. The common cockle (Cerastoderma edule) is a valuable species from ecological and commercial perspectives which shows important variation in shell color across Northeast Atlantic. In this study, we constructed a high-density genetic map, as a tool for screening common cockle genome, which was applied to ascertain the genetic basis of color variation in the species. The consensus genetic map comprised 19 linkage groups (LGs) in accordance with the cockle karyotype (2n = 38) and spanned 1073 cM, including 730 markers per LG and an inter-marker distance of 0.13 cM. Five full-sib families showing segregation for several color-associated traits were used for a genome-wide association study and a major QTL on chromosome 13 associated to different color-traits was detected. Mining on this genomic region revealed several candidate genes related to shell construction and color. A genomic region previously reported associated with divergent selection in cockle distribution overlapped with this QTL suggesting its putative role on adaptation. |
format |
Article in Journal/Newspaper |
author |
Miguel Hermida Diego Robledo Seila Díaz Damián Costas Alicia L. Bruzos Andrés Blanco Belén G. Pardo Paulino Martínez |
author_facet |
Miguel Hermida Diego Robledo Seila Díaz Damián Costas Alicia L. Bruzos Andrés Blanco Belén G. Pardo Paulino Martínez |
author_sort |
Miguel Hermida |
title |
The first high-density genetic map of common cockle (Cerastoderma edule) reveals a major QTL controlling shell color variation |
title_short |
The first high-density genetic map of common cockle (Cerastoderma edule) reveals a major QTL controlling shell color variation |
title_full |
The first high-density genetic map of common cockle (Cerastoderma edule) reveals a major QTL controlling shell color variation |
title_fullStr |
The first high-density genetic map of common cockle (Cerastoderma edule) reveals a major QTL controlling shell color variation |
title_full_unstemmed |
The first high-density genetic map of common cockle (Cerastoderma edule) reveals a major QTL controlling shell color variation |
title_sort |
first high-density genetic map of common cockle (cerastoderma edule) reveals a major qtl controlling shell color variation |
publisher |
Nature Portfolio |
publishDate |
2022 |
url |
https://doi.org/10.1038/s41598-022-21214-3 https://doaj.org/article/3cd9ed04952b412d86527410ec29df43 |
genre |
Northeast Atlantic |
genre_facet |
Northeast Atlantic |
op_source |
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022) |
op_relation |
https://doi.org/10.1038/s41598-022-21214-3 https://doaj.org/toc/2045-2322 doi:10.1038/s41598-022-21214-3 2045-2322 https://doaj.org/article/3cd9ed04952b412d86527410ec29df43 |
op_doi |
https://doi.org/10.1038/s41598-022-21214-3 |
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Scientific Reports |
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12 |
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1 |
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1766143071307694080 |