Congenital Plasmodium falciparum infection in neonates in Muheza District, Tanzania
Abstract Background Although recent reports on congenital malaria suggest that the incidence is increasing, it is difficult to determine whether the clinical disease is due to parasites acquired before delivery or as a result of contamination by maternal blood at birth. Understanding of the method o...
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ftdoajarticles:oai:doaj.org/article:3ca05711dcc54f279d898facc86cb75f 2023-05-15T15:16:07+02:00 Congenital Plasmodium falciparum infection in neonates in Muheza District, Tanzania Kimera Sharadhuli I Mwangoka Grace W Mboera Leonard EG 2008-07-01T00:00:00Z https://doi.org/10.1186/1475-2875-7-117 https://doaj.org/article/3ca05711dcc54f279d898facc86cb75f EN eng BMC http://www.malariajournal.com/content/7/1/117 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-7-117 1475-2875 https://doaj.org/article/3ca05711dcc54f279d898facc86cb75f Malaria Journal, Vol 7, Iss 1, p 117 (2008) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2008 ftdoajarticles https://doi.org/10.1186/1475-2875-7-117 2022-12-30T22:26:24Z Abstract Background Although recent reports on congenital malaria suggest that the incidence is increasing, it is difficult to determine whether the clinical disease is due to parasites acquired before delivery or as a result of contamination by maternal blood at birth. Understanding of the method of parasite acquisition is important for estimating the time incidence of congenital malaria and design of preventive measures. The aim of this study was to determine whether the first Plasmodium falciparum malaria disease in infants is due to same parasites present on the placenta at birth. Methods Babies born to mothers with P. falciparum parasites on the placenta detected by PCR were followed up to two years and observed for malaria episodes. Paired placental and infant peripheral blood samples at first malaria episode within first three months of life were genotyped ( msp2 ) to determine genetic relatedness. Selected amplifications from nested PCR were sequenced and compared between pairs. Results Eighteen (19.1%) out of 95 infants who were followed up developed clinical malaria within the first three months of age. Eight pairs (60%) out of 14 pairs of sequenced placental and cord samples were genetically related while six (40%) were genetically unrelated. One pair (14.3%) out of seven pairs of sequenced placental and infants samples were genetically related. In addition, infants born from primigravidae mothers were more likely to be infected with P. falciparum ( P < 0.001) as compared to infants from secundigravidae and multigravidae mothers during the two years of follow up. Infants from multigravidae mothers got the first P. falciparum infection earlier than those from secundigravidae and primigravidae mothers (RR = 1.43). Conclusion Plasmodium falciparum malaria parasites present on the placenta as detected by PCR are more likely to result in clinical disease (congenital malaria) in the infant during the first three months of life. However, sequencing data seem to question the validity of this likelihood. ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 7 1 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Kimera Sharadhuli I Mwangoka Grace W Mboera Leonard EG Congenital Plasmodium falciparum infection in neonates in Muheza District, Tanzania |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Although recent reports on congenital malaria suggest that the incidence is increasing, it is difficult to determine whether the clinical disease is due to parasites acquired before delivery or as a result of contamination by maternal blood at birth. Understanding of the method of parasite acquisition is important for estimating the time incidence of congenital malaria and design of preventive measures. The aim of this study was to determine whether the first Plasmodium falciparum malaria disease in infants is due to same parasites present on the placenta at birth. Methods Babies born to mothers with P. falciparum parasites on the placenta detected by PCR were followed up to two years and observed for malaria episodes. Paired placental and infant peripheral blood samples at first malaria episode within first three months of life were genotyped ( msp2 ) to determine genetic relatedness. Selected amplifications from nested PCR were sequenced and compared between pairs. Results Eighteen (19.1%) out of 95 infants who were followed up developed clinical malaria within the first three months of age. Eight pairs (60%) out of 14 pairs of sequenced placental and cord samples were genetically related while six (40%) were genetically unrelated. One pair (14.3%) out of seven pairs of sequenced placental and infants samples were genetically related. In addition, infants born from primigravidae mothers were more likely to be infected with P. falciparum ( P < 0.001) as compared to infants from secundigravidae and multigravidae mothers during the two years of follow up. Infants from multigravidae mothers got the first P. falciparum infection earlier than those from secundigravidae and primigravidae mothers (RR = 1.43). Conclusion Plasmodium falciparum malaria parasites present on the placenta as detected by PCR are more likely to result in clinical disease (congenital malaria) in the infant during the first three months of life. However, sequencing data seem to question the validity of this likelihood. ... |
format |
Article in Journal/Newspaper |
author |
Kimera Sharadhuli I Mwangoka Grace W Mboera Leonard EG |
author_facet |
Kimera Sharadhuli I Mwangoka Grace W Mboera Leonard EG |
author_sort |
Kimera Sharadhuli I |
title |
Congenital Plasmodium falciparum infection in neonates in Muheza District, Tanzania |
title_short |
Congenital Plasmodium falciparum infection in neonates in Muheza District, Tanzania |
title_full |
Congenital Plasmodium falciparum infection in neonates in Muheza District, Tanzania |
title_fullStr |
Congenital Plasmodium falciparum infection in neonates in Muheza District, Tanzania |
title_full_unstemmed |
Congenital Plasmodium falciparum infection in neonates in Muheza District, Tanzania |
title_sort |
congenital plasmodium falciparum infection in neonates in muheza district, tanzania |
publisher |
BMC |
publishDate |
2008 |
url |
https://doi.org/10.1186/1475-2875-7-117 https://doaj.org/article/3ca05711dcc54f279d898facc86cb75f |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 7, Iss 1, p 117 (2008) |
op_relation |
http://www.malariajournal.com/content/7/1/117 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-7-117 1475-2875 https://doaj.org/article/3ca05711dcc54f279d898facc86cb75f |
op_doi |
https://doi.org/10.1186/1475-2875-7-117 |
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Malaria Journal |
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7 |
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1 |
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1766346422479749120 |