Russian registry of hypothalamic and pituitary tumors: clinical and statistical analysis for 01.01.2023

• Published in: Obesity and metabolism
• Main Authors: A. S. Lutsenko, E. G. Przhiyalkovskaya, O. K. Vikulova, M. A. Isakov, Zh. E. Belaya, L. Ya. Rozhinskaya, E. A. Pigarova, L. K. Dzeranova, E. I. Marova, G. A. Melnichenko, N. M. Platonova, E. A. Troshina, N. G. Mokrysheva
• Format: Article in Journal/Newspaper
• Language: English; Russian
• Published: Endocrinology Research Centre 2024
• Subjects: registry; epidemiology; acromegaly; cushing’s disease; prolactinoma; pituitary adenoma; Physiology; QP1-981; Biochemistry; QD415-436; Sakha; Chukotka; Yakutia; Yakutia Republic
• Online Access: https://doi.org/10.14341/omet13054; https://doaj.org/article/3c8fb017bc52413f98ecfcac654d7e6f

BACKGROUND: Pituitary adenomas are the third most common intracranial neoplasm. Clinical significance is determined by the nature of growth and hormonal activity, leading to disruption of various parts of metabolism. Medical registries are a valuable tool for assessing clinical and epidemiological parameters and obtaining data on real-life clinical practice.AIM: To analyze the epidemiological and clinical characteristics of four pituitary disorders in Russian Hypothalamic and Pituitary Tumor Registry (OGGO): acromegaly, Cushing’s disease, prolactin-secreting and non-functioning pituitary adenomasMATERIALS AND METHODS: The object of the study is the database of the OGGO registry, which includes 84 regions of the Russian Federation, as of 01/01/2023.RESULTS: The maximum prevalence of acromegaly in the Russian Federation was noted in Karelia (9.48/100 thousand) and Chuvash Republic (10.8/100 thousand) and in Tyumen region (8.9/100 thousand). The incidence of acromegaly in 2021 was 0.6/1 million population. The maximum prevalence of Cushing’s disease is observed in Karelia Republic (2.33/100 thousand), Chukotka (2.01/100 thousand), Kirov (1.79/100 thousand) and Tver region ( 1.79/100 thousand). The incidence of Cushing’s disease in 2021 was 0.1/1 million population. The maximum prevalence of prolactinomas is observed Karelia (13.33/100 thousand) and Chuvash Republic (12.35/100 thousand) and in Voronezh region (8.66/100 thousand). The incidence of prolactin-secreting adenomas in 2021 was 0.6/1 million population. The maximum prevalence of non-functioning pituitary adenomas is observed in the Karelia (15.08/100 thousand), Voronezh region (8.82/100 thousand), Tyumen region (8.11/100 thousand) and Sakha/Yakutia Republic (7.56 /100 thousand). The incidence of non-functioning pituitary adenomas in 2021 was 0.3/1 million population. The median age for acromegaly was 63.6 [53.2;71.5], for Cushing’s disease 49.2 [38.8;60.8], for prolactin-secreting adenomas 47.5 [38.3;59.7], for patients with non-functioning pituitary ...