Evidence of gene conversion in genes encoding the Gal/GalNac lectin complex of Entamoeba.
The human gut parasite Entamoeba histolytica, uses a lectin complex on its cell surface to bind to mucin and to ligands on the intestinal epithelia. Binding to mucin is necessary for colonisation and binding to intestinal epithelia for invasion, therefore blocking this binding may protect against am...
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ftdoajarticles:oai:doaj.org/article:3c8b6674d95a429a80ecc5c125a12f19 2023-05-15T15:01:30+02:00 Evidence of gene conversion in genes encoding the Gal/GalNac lectin complex of Entamoeba. Gareth D Weedall James Sherrington Steve Paterson Neil Hall 2011-06-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0001209 https://doaj.org/article/3c8b6674d95a429a80ecc5c125a12f19 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3125142?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0001209 https://doaj.org/article/3c8b6674d95a429a80ecc5c125a12f19 PLoS Neglected Tropical Diseases, Vol 5, Iss 6, p e1209 (2011) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2011 ftdoajarticles https://doi.org/10.1371/journal.pntd.0001209 2022-12-30T22:30:04Z The human gut parasite Entamoeba histolytica, uses a lectin complex on its cell surface to bind to mucin and to ligands on the intestinal epithelia. Binding to mucin is necessary for colonisation and binding to intestinal epithelia for invasion, therefore blocking this binding may protect against amoebiasis. Acquired protective immunity raised against the lectin complex should create a selection pressure to change the amino acid sequence of lectin genes in order to avoid future detection. We present evidence that gene conversion has occurred in lineages leading to E. histolytica strain HM1:IMSS and E. dispar strain SAW760. This evolutionary mechanism generates diversity and could contribute to immune evasion by the parasites. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 5 6 e1209 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Gareth D Weedall James Sherrington Steve Paterson Neil Hall Evidence of gene conversion in genes encoding the Gal/GalNac lectin complex of Entamoeba. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
The human gut parasite Entamoeba histolytica, uses a lectin complex on its cell surface to bind to mucin and to ligands on the intestinal epithelia. Binding to mucin is necessary for colonisation and binding to intestinal epithelia for invasion, therefore blocking this binding may protect against amoebiasis. Acquired protective immunity raised against the lectin complex should create a selection pressure to change the amino acid sequence of lectin genes in order to avoid future detection. We present evidence that gene conversion has occurred in lineages leading to E. histolytica strain HM1:IMSS and E. dispar strain SAW760. This evolutionary mechanism generates diversity and could contribute to immune evasion by the parasites. |
format |
Article in Journal/Newspaper |
author |
Gareth D Weedall James Sherrington Steve Paterson Neil Hall |
author_facet |
Gareth D Weedall James Sherrington Steve Paterson Neil Hall |
author_sort |
Gareth D Weedall |
title |
Evidence of gene conversion in genes encoding the Gal/GalNac lectin complex of Entamoeba. |
title_short |
Evidence of gene conversion in genes encoding the Gal/GalNac lectin complex of Entamoeba. |
title_full |
Evidence of gene conversion in genes encoding the Gal/GalNac lectin complex of Entamoeba. |
title_fullStr |
Evidence of gene conversion in genes encoding the Gal/GalNac lectin complex of Entamoeba. |
title_full_unstemmed |
Evidence of gene conversion in genes encoding the Gal/GalNac lectin complex of Entamoeba. |
title_sort |
evidence of gene conversion in genes encoding the gal/galnac lectin complex of entamoeba. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2011 |
url |
https://doi.org/10.1371/journal.pntd.0001209 https://doaj.org/article/3c8b6674d95a429a80ecc5c125a12f19 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 5, Iss 6, p e1209 (2011) |
op_relation |
http://europepmc.org/articles/PMC3125142?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0001209 https://doaj.org/article/3c8b6674d95a429a80ecc5c125a12f19 |
op_doi |
https://doi.org/10.1371/journal.pntd.0001209 |
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PLoS Neglected Tropical Diseases |
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5 |
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6 |
container_start_page |
e1209 |
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1766333521586028544 |