In vivo susceptibility of Plasmodium falciparum to artesunate in Binh Phuoc Province, Vietnam
Abstract Background By 2009, there were worrying signs from western Cambodia that parasitological responses to artesunate-containing treatment regimens for uncomplicated Plasmodium falciparum malaria were slower than elsewhere which suggested the emergence of artemisinin resistance. Vietnam shares a...
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ftdoajarticles:oai:doaj.org/article:3c7ecf9343324e6092a07e122a2cd4e1 2023-05-15T15:17:13+02:00 In vivo susceptibility of Plasmodium falciparum to artesunate in Binh Phuoc Province, Vietnam Hien Tran Thuy-Nhien Nguyen Phu Nguyen Boni Maciej F Thanh Ngo Nha-Ca Nguyen Thai Le Thai Cao Van Toi Pham Thuan Phung Long Le Dong Le Merson Laura Dolecek Christiane Stepniewska Kasia Ringwald Pascal White Nicholas J Farrar Jeremy Wolbers Marcel 2012-10-01T00:00:00Z https://doi.org/10.1186/1475-2875-11-355 https://doaj.org/article/3c7ecf9343324e6092a07e122a2cd4e1 EN eng BMC http://www.malariajournal.com/content/11/1/355 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-11-355 1475-2875 https://doaj.org/article/3c7ecf9343324e6092a07e122a2cd4e1 Malaria Journal, Vol 11, Iss 1, p 355 (2012) Plasmodium falciparum Artesunate Parasite clearance half-life Parasite reduction ratio Parasite clearance of >72 hours Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2012 ftdoajarticles https://doi.org/10.1186/1475-2875-11-355 2022-12-31T00:55:38Z Abstract Background By 2009, there were worrying signs from western Cambodia that parasitological responses to artesunate-containing treatment regimens for uncomplicated Plasmodium falciparum malaria were slower than elsewhere which suggested the emergence of artemisinin resistance. Vietnam shares a long land border with Cambodia with a large number of migrants crossing it on a daily basis. Therefore, there is an urgent need to investigate whether there is any evidence of a change in the parasitological response to the artemisinin derivatives in Vietnam. Methods From August 2010 to May 2011, a randomized controlled clinical trial in uncomplicated falciparum malaria was conducted to compare two doses of artesunate (AS) (2mg/kg/day versus 4 mg/kg/day for three days) followed by dihydroartemisinin-piperaquine (DHA-PPQ) and a control arm of DHA-PPQ. The goal was characterization of the current efficacy of artesunate in southern Vietnam. The primary endpoint of this study was the parasite clearance half-life; secondary endpoints included the parasite reduction ratios at 24 and 48 hours and the parasite clearance time. Results 166 patients were recruited into the study. The median parasite clearance half-lives were 3.54 (AS 2mg/kg), 2.72 (AS 4mg/kg), and 2.98 hours (DHA-PPQ) (p=0.19). The median parasite-reduction ratio at 24 hours was 48 in the AS 2mg/kg group compared with 212 and 113 in the other two groups, respectively (p=0.02). The proportions of patients with a parasite clearance time of >72 hours for AS 2mg/kg, AS 4mg/kg and DHA-PPQ were 27%, 27%, and 22%, respectively. Early treatment failure occurred in two (4%) and late clinical failure occurred in one (2%) of the 55 patients in the AS 2mg/kg group, as compared with none in the other two study arms. The PCR-corrected adequate clinical and parasitological response (APCR) rates in the three groups were 94%, 100%, and 100% (p=0.04). Conclusions This study demonstrated faster P . falciparum parasite clearance in southern Vietnam than in western Cambodia but ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 11 1 |
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topic |
Plasmodium falciparum Artesunate Parasite clearance half-life Parasite reduction ratio Parasite clearance of >72 hours Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Plasmodium falciparum Artesunate Parasite clearance half-life Parasite reduction ratio Parasite clearance of >72 hours Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Hien Tran Thuy-Nhien Nguyen Phu Nguyen Boni Maciej F Thanh Ngo Nha-Ca Nguyen Thai Le Thai Cao Van Toi Pham Thuan Phung Long Le Dong Le Merson Laura Dolecek Christiane Stepniewska Kasia Ringwald Pascal White Nicholas J Farrar Jeremy Wolbers Marcel In vivo susceptibility of Plasmodium falciparum to artesunate in Binh Phuoc Province, Vietnam |
topic_facet |
Plasmodium falciparum Artesunate Parasite clearance half-life Parasite reduction ratio Parasite clearance of >72 hours Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background By 2009, there were worrying signs from western Cambodia that parasitological responses to artesunate-containing treatment regimens for uncomplicated Plasmodium falciparum malaria were slower than elsewhere which suggested the emergence of artemisinin resistance. Vietnam shares a long land border with Cambodia with a large number of migrants crossing it on a daily basis. Therefore, there is an urgent need to investigate whether there is any evidence of a change in the parasitological response to the artemisinin derivatives in Vietnam. Methods From August 2010 to May 2011, a randomized controlled clinical trial in uncomplicated falciparum malaria was conducted to compare two doses of artesunate (AS) (2mg/kg/day versus 4 mg/kg/day for three days) followed by dihydroartemisinin-piperaquine (DHA-PPQ) and a control arm of DHA-PPQ. The goal was characterization of the current efficacy of artesunate in southern Vietnam. The primary endpoint of this study was the parasite clearance half-life; secondary endpoints included the parasite reduction ratios at 24 and 48 hours and the parasite clearance time. Results 166 patients were recruited into the study. The median parasite clearance half-lives were 3.54 (AS 2mg/kg), 2.72 (AS 4mg/kg), and 2.98 hours (DHA-PPQ) (p=0.19). The median parasite-reduction ratio at 24 hours was 48 in the AS 2mg/kg group compared with 212 and 113 in the other two groups, respectively (p=0.02). The proportions of patients with a parasite clearance time of >72 hours for AS 2mg/kg, AS 4mg/kg and DHA-PPQ were 27%, 27%, and 22%, respectively. Early treatment failure occurred in two (4%) and late clinical failure occurred in one (2%) of the 55 patients in the AS 2mg/kg group, as compared with none in the other two study arms. The PCR-corrected adequate clinical and parasitological response (APCR) rates in the three groups were 94%, 100%, and 100% (p=0.04). Conclusions This study demonstrated faster P . falciparum parasite clearance in southern Vietnam than in western Cambodia but ... |
format |
Article in Journal/Newspaper |
author |
Hien Tran Thuy-Nhien Nguyen Phu Nguyen Boni Maciej F Thanh Ngo Nha-Ca Nguyen Thai Le Thai Cao Van Toi Pham Thuan Phung Long Le Dong Le Merson Laura Dolecek Christiane Stepniewska Kasia Ringwald Pascal White Nicholas J Farrar Jeremy Wolbers Marcel |
author_facet |
Hien Tran Thuy-Nhien Nguyen Phu Nguyen Boni Maciej F Thanh Ngo Nha-Ca Nguyen Thai Le Thai Cao Van Toi Pham Thuan Phung Long Le Dong Le Merson Laura Dolecek Christiane Stepniewska Kasia Ringwald Pascal White Nicholas J Farrar Jeremy Wolbers Marcel |
author_sort |
Hien Tran |
title |
In vivo susceptibility of Plasmodium falciparum to artesunate in Binh Phuoc Province, Vietnam |
title_short |
In vivo susceptibility of Plasmodium falciparum to artesunate in Binh Phuoc Province, Vietnam |
title_full |
In vivo susceptibility of Plasmodium falciparum to artesunate in Binh Phuoc Province, Vietnam |
title_fullStr |
In vivo susceptibility of Plasmodium falciparum to artesunate in Binh Phuoc Province, Vietnam |
title_full_unstemmed |
In vivo susceptibility of Plasmodium falciparum to artesunate in Binh Phuoc Province, Vietnam |
title_sort |
in vivo susceptibility of plasmodium falciparum to artesunate in binh phuoc province, vietnam |
publisher |
BMC |
publishDate |
2012 |
url |
https://doi.org/10.1186/1475-2875-11-355 https://doaj.org/article/3c7ecf9343324e6092a07e122a2cd4e1 |
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Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 11, Iss 1, p 355 (2012) |
op_relation |
http://www.malariajournal.com/content/11/1/355 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-11-355 1475-2875 https://doaj.org/article/3c7ecf9343324e6092a07e122a2cd4e1 |
op_doi |
https://doi.org/10.1186/1475-2875-11-355 |
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Malaria Journal |
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11 |
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