A Cost-Effectiveness Tool for Informing Policies on Zika Virus Control.
BACKGROUND:As Zika virus continues to spread, decisions regarding resource allocations to control the outbreak underscore the need for a tool to weigh policies according to their cost and the health burden they could avert. For example, to combat the current Zika outbreak the US President requested...
Published in: | PLOS Neglected Tropical Diseases |
---|---|
Main Authors: | , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Public Library of Science (PLoS)
2016
|
Subjects: | |
Online Access: | https://doi.org/10.1371/journal.pntd.0004743 https://doaj.org/article/3c70dbfc49a746b6ab2179ddd99ff7d9 |
id |
ftdoajarticles:oai:doaj.org/article:3c70dbfc49a746b6ab2179ddd99ff7d9 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:3c70dbfc49a746b6ab2179ddd99ff7d9 2023-05-15T15:16:46+02:00 A Cost-Effectiveness Tool for Informing Policies on Zika Virus Control. Jorge A Alfaro-Murillo Alyssa S Parpia Meagan C Fitzpatrick Jules A Tamagnan Jan Medlock Martial L Ndeffo-Mbah Durland Fish María L Ávila-Agüero Rodrigo Marín Albert I Ko Alison P Galvani 2016-05-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0004743 https://doaj.org/article/3c70dbfc49a746b6ab2179ddd99ff7d9 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4874682?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004743 https://doaj.org/article/3c70dbfc49a746b6ab2179ddd99ff7d9 PLoS Neglected Tropical Diseases, Vol 10, Iss 5, p e0004743 (2016) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2016 ftdoajarticles https://doi.org/10.1371/journal.pntd.0004743 2022-12-31T16:33:41Z BACKGROUND:As Zika virus continues to spread, decisions regarding resource allocations to control the outbreak underscore the need for a tool to weigh policies according to their cost and the health burden they could avert. For example, to combat the current Zika outbreak the US President requested the allocation of $1.8 billion from Congress in February 2016. METHODOLOGY/PRINCIPAL FINDINGS:Illustrated through an interactive tool, we evaluated how the number of Zika cases averted, the period during pregnancy in which Zika infection poses a risk of microcephaly, and probabilities of microcephaly and Guillain-Barré Syndrome (GBS) impact the cost at which an intervention is cost-effective. From Northeast Brazilian microcephaly incidence data, we estimated the probability of microcephaly in infants born to Zika-infected women (0.49% to 2.10%). We also estimated the probability of GBS arising from Zika infections in Brazil (0.02% to 0.06%) and Colombia (0.08%). We calculated that each microcephaly and GBS case incurs the loss of 29.95 DALYs and 1.25 DALYs per case, as well as direct medical costs for Latin America and the Caribbean of $91,102 and $28,818, respectively. We demonstrated the utility of our cost-effectiveness tool with examples evaluating funding commitments by Costa Rica and Brazil, the US presidential proposal, and the novel approach of genetically modified mosquitoes. Our analyses indicate that the commitments and the proposal are likely to be cost-effective, whereas the cost-effectiveness of genetically modified mosquitoes depends on the country of implementation. CONCLUSIONS/SIGNIFICANCE:Current estimates from our tool suggest that the health burden from microcephaly and GBS warrants substantial expenditures focused on Zika virus control. Our results justify the funding committed in Costa Rica and Brazil and many aspects of the budget outlined in the US president's proposal. As data continue to be collected, new parameter estimates can be customized in real-time within our user-friendly tool to ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Barré ENVELOPE(-68.550,-68.550,-67.500,-67.500) PLOS Neglected Tropical Diseases 10 5 e0004743 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Jorge A Alfaro-Murillo Alyssa S Parpia Meagan C Fitzpatrick Jules A Tamagnan Jan Medlock Martial L Ndeffo-Mbah Durland Fish María L Ávila-Agüero Rodrigo Marín Albert I Ko Alison P Galvani A Cost-Effectiveness Tool for Informing Policies on Zika Virus Control. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND:As Zika virus continues to spread, decisions regarding resource allocations to control the outbreak underscore the need for a tool to weigh policies according to their cost and the health burden they could avert. For example, to combat the current Zika outbreak the US President requested the allocation of $1.8 billion from Congress in February 2016. METHODOLOGY/PRINCIPAL FINDINGS:Illustrated through an interactive tool, we evaluated how the number of Zika cases averted, the period during pregnancy in which Zika infection poses a risk of microcephaly, and probabilities of microcephaly and Guillain-Barré Syndrome (GBS) impact the cost at which an intervention is cost-effective. From Northeast Brazilian microcephaly incidence data, we estimated the probability of microcephaly in infants born to Zika-infected women (0.49% to 2.10%). We also estimated the probability of GBS arising from Zika infections in Brazil (0.02% to 0.06%) and Colombia (0.08%). We calculated that each microcephaly and GBS case incurs the loss of 29.95 DALYs and 1.25 DALYs per case, as well as direct medical costs for Latin America and the Caribbean of $91,102 and $28,818, respectively. We demonstrated the utility of our cost-effectiveness tool with examples evaluating funding commitments by Costa Rica and Brazil, the US presidential proposal, and the novel approach of genetically modified mosquitoes. Our analyses indicate that the commitments and the proposal are likely to be cost-effective, whereas the cost-effectiveness of genetically modified mosquitoes depends on the country of implementation. CONCLUSIONS/SIGNIFICANCE:Current estimates from our tool suggest that the health burden from microcephaly and GBS warrants substantial expenditures focused on Zika virus control. Our results justify the funding committed in Costa Rica and Brazil and many aspects of the budget outlined in the US president's proposal. As data continue to be collected, new parameter estimates can be customized in real-time within our user-friendly tool to ... |
format |
Article in Journal/Newspaper |
author |
Jorge A Alfaro-Murillo Alyssa S Parpia Meagan C Fitzpatrick Jules A Tamagnan Jan Medlock Martial L Ndeffo-Mbah Durland Fish María L Ávila-Agüero Rodrigo Marín Albert I Ko Alison P Galvani |
author_facet |
Jorge A Alfaro-Murillo Alyssa S Parpia Meagan C Fitzpatrick Jules A Tamagnan Jan Medlock Martial L Ndeffo-Mbah Durland Fish María L Ávila-Agüero Rodrigo Marín Albert I Ko Alison P Galvani |
author_sort |
Jorge A Alfaro-Murillo |
title |
A Cost-Effectiveness Tool for Informing Policies on Zika Virus Control. |
title_short |
A Cost-Effectiveness Tool for Informing Policies on Zika Virus Control. |
title_full |
A Cost-Effectiveness Tool for Informing Policies on Zika Virus Control. |
title_fullStr |
A Cost-Effectiveness Tool for Informing Policies on Zika Virus Control. |
title_full_unstemmed |
A Cost-Effectiveness Tool for Informing Policies on Zika Virus Control. |
title_sort |
cost-effectiveness tool for informing policies on zika virus control. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2016 |
url |
https://doi.org/10.1371/journal.pntd.0004743 https://doaj.org/article/3c70dbfc49a746b6ab2179ddd99ff7d9 |
long_lat |
ENVELOPE(-68.550,-68.550,-67.500,-67.500) |
geographic |
Arctic Barré |
geographic_facet |
Arctic Barré |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 10, Iss 5, p e0004743 (2016) |
op_relation |
http://europepmc.org/articles/PMC4874682?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004743 https://doaj.org/article/3c70dbfc49a746b6ab2179ddd99ff7d9 |
op_doi |
https://doi.org/10.1371/journal.pntd.0004743 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
10 |
container_issue |
5 |
container_start_page |
e0004743 |
_version_ |
1766347061334114304 |