Treatment of severe chromoblastomycosis with itraconazole and 5-flucytosine association

• Published in: Revista do Instituto de Medicina Tropical de São Paulo
• Main Authors: Vicente Sperb Antonello, Marcelo Campos Appel da Silva, Eduardo Cambruzzi, Dimas Alexandre Kliemann, Breno Riegel Santos, Flávio Queiroz-Telles
• Format: Article in Journal/Newspaper
• Language: English
• Published: Universidade de São Paulo (USP) 2010
• Subjects: Chromoblastomycosis; Itraconazole; 5-Flucytosine; Subcutaneous mycoses; Arctic medicine. Tropical medicine; RC955-962; Infectious and parasitic diseases; RC109-216; Arctic
• Online Access: https://doi.org/10.1590/S0036-46652010000600008; https://doaj.org/article/3c4fd4d96b24443ebe574dff876cbded

Chromoblastomycosis is a chronic human melanized fungi infection of the subcutaneous tissue caused by traumatic inoculation of a specific group of dematiaceous fungi through the skin, often found in barefooted agricultural workers, in tropical and subtropical climate countries. We report the case of a male patient presenting a slow-growing pruriginous lesion on the limbs for 20 years, mistreated over that time, which was diagnosed and successfully treated as chromoblastomycosis. Besides the prevalence of this disease, treatment is still a clinical challenge.