Malaria in humait a county, state of Amazonas, Brazil. XIX - evaluation of clindamycin for the treatment of patients with Plasmodium falciparum infection
A total of 207 patients with malaria caused by Plasmodium falciparum were submitted to 5 different treatment schedules with clindamycin from 1981 to 1984: A - 89 patients were treated intravenously and orally, or intramuscularly and orally with 20 mg/kg/day divided into two daily applications for 5...
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Sociedade Brasileira de Medicina Tropical (SBMT)
1988
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Online Access: | https://doi.org/10.1590/S0037-86821988000300005 https://doaj.org/article/3c15a9b097224547a0050cde4fd2afb1 |
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ftdoajarticles:oai:doaj.org/article:3c15a9b097224547a0050cde4fd2afb1 2023-05-15T15:11:52+02:00 Malaria in humait a county, state of Amazonas, Brazil. XIX - evaluation of clindamycin for the treatment of patients with Plasmodium falciparum infection Domingos Alves Meira Paulo Camara Marques Pereira Jussara Marcondes-Machado Rinaido Poncio Mendes Benedito Barraviera José Antonio G. Pirola Maria Regina Cotrim Guimarães Paulo Roberto Curi Renato Pedro Rodrigues 1988-09-01T00:00:00Z https://doi.org/10.1590/S0037-86821988000300005 https://doaj.org/article/3c15a9b097224547a0050cde4fd2afb1 EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821988000300005&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/S0037-86821988000300005 https://doaj.org/article/3c15a9b097224547a0050cde4fd2afb1 Revista da Sociedade Brasileira de Medicina Tropical, Vol 21, Iss 3, Pp 123-129 (1988) Tratamento da malária Plasmodium falciparum Clindamicina Arctic medicine. Tropical medicine RC955-962 article 1988 ftdoajarticles https://doi.org/10.1590/S0037-86821988000300005 2022-12-30T23:06:49Z A total of 207 patients with malaria caused by Plasmodium falciparum were submitted to 5 different treatment schedules with clindamycin from 1981 to 1984: A - 89 patients were treated intravenously and orally, or intramuscularly and orally with 20 mg/kg/day divided into two daily applications for 5 to 7 days; B-40 patients were treated orally with 20 mg/kg/day divided into two daily doses for 5 to 7 days; C-27 patients were treated with 20 mg/kg/day intravenously or orally divided into two daily applications for 3 days; D-16 patients were treated orally and/or intravenously with a single daily dose of 20 to 40 mg/kg/day for 5 to 7 days; E-35 patients were treated orally with 5 mg/kg/day divided into two doses for 5 days. Patients were examined daily during treatment and reexamined on the 7th, 24th, 21st, 28th and 35th day both clinically and parasitologically (blood test). Eighty three (40.1%) had moderate or severe malaria, and 97 (46.8%) had shown resistance to chloroquine or to the combination ofsulfadoxin and pyrimethamine. The proportion of cured patients was higher than 95% among patients submitted to schedules A and B. Side effects were only occasional and of low intensity. Three deaths occurred (1.4%), two of them involving patients whose signs and symptoms were already very severe when treatment was started. Thus, clindamycin proved to be very useful in the treatment of patients with malaria caused by Plasmodium falciparum and we recommend schedule A for moderate and severe cases and Bfor initial cases. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista da Sociedade Brasileira de Medicina Tropical 21 3 123 129 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Tratamento da malária Plasmodium falciparum Clindamicina Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Tratamento da malária Plasmodium falciparum Clindamicina Arctic medicine. Tropical medicine RC955-962 Domingos Alves Meira Paulo Camara Marques Pereira Jussara Marcondes-Machado Rinaido Poncio Mendes Benedito Barraviera José Antonio G. Pirola Maria Regina Cotrim Guimarães Paulo Roberto Curi Renato Pedro Rodrigues Malaria in humait a county, state of Amazonas, Brazil. XIX - evaluation of clindamycin for the treatment of patients with Plasmodium falciparum infection |
topic_facet |
Tratamento da malária Plasmodium falciparum Clindamicina Arctic medicine. Tropical medicine RC955-962 |
description |
A total of 207 patients with malaria caused by Plasmodium falciparum were submitted to 5 different treatment schedules with clindamycin from 1981 to 1984: A - 89 patients were treated intravenously and orally, or intramuscularly and orally with 20 mg/kg/day divided into two daily applications for 5 to 7 days; B-40 patients were treated orally with 20 mg/kg/day divided into two daily doses for 5 to 7 days; C-27 patients were treated with 20 mg/kg/day intravenously or orally divided into two daily applications for 3 days; D-16 patients were treated orally and/or intravenously with a single daily dose of 20 to 40 mg/kg/day for 5 to 7 days; E-35 patients were treated orally with 5 mg/kg/day divided into two doses for 5 days. Patients were examined daily during treatment and reexamined on the 7th, 24th, 21st, 28th and 35th day both clinically and parasitologically (blood test). Eighty three (40.1%) had moderate or severe malaria, and 97 (46.8%) had shown resistance to chloroquine or to the combination ofsulfadoxin and pyrimethamine. The proportion of cured patients was higher than 95% among patients submitted to schedules A and B. Side effects were only occasional and of low intensity. Three deaths occurred (1.4%), two of them involving patients whose signs and symptoms were already very severe when treatment was started. Thus, clindamycin proved to be very useful in the treatment of patients with malaria caused by Plasmodium falciparum and we recommend schedule A for moderate and severe cases and Bfor initial cases. |
format |
Article in Journal/Newspaper |
author |
Domingos Alves Meira Paulo Camara Marques Pereira Jussara Marcondes-Machado Rinaido Poncio Mendes Benedito Barraviera José Antonio G. Pirola Maria Regina Cotrim Guimarães Paulo Roberto Curi Renato Pedro Rodrigues |
author_facet |
Domingos Alves Meira Paulo Camara Marques Pereira Jussara Marcondes-Machado Rinaido Poncio Mendes Benedito Barraviera José Antonio G. Pirola Maria Regina Cotrim Guimarães Paulo Roberto Curi Renato Pedro Rodrigues |
author_sort |
Domingos Alves Meira |
title |
Malaria in humait a county, state of Amazonas, Brazil. XIX - evaluation of clindamycin for the treatment of patients with Plasmodium falciparum infection |
title_short |
Malaria in humait a county, state of Amazonas, Brazil. XIX - evaluation of clindamycin for the treatment of patients with Plasmodium falciparum infection |
title_full |
Malaria in humait a county, state of Amazonas, Brazil. XIX - evaluation of clindamycin for the treatment of patients with Plasmodium falciparum infection |
title_fullStr |
Malaria in humait a county, state of Amazonas, Brazil. XIX - evaluation of clindamycin for the treatment of patients with Plasmodium falciparum infection |
title_full_unstemmed |
Malaria in humait a county, state of Amazonas, Brazil. XIX - evaluation of clindamycin for the treatment of patients with Plasmodium falciparum infection |
title_sort |
malaria in humait a county, state of amazonas, brazil. xix - evaluation of clindamycin for the treatment of patients with plasmodium falciparum infection |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
1988 |
url |
https://doi.org/10.1590/S0037-86821988000300005 https://doaj.org/article/3c15a9b097224547a0050cde4fd2afb1 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 21, Iss 3, Pp 123-129 (1988) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821988000300005&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/S0037-86821988000300005 https://doaj.org/article/3c15a9b097224547a0050cde4fd2afb1 |
op_doi |
https://doi.org/10.1590/S0037-86821988000300005 |
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Revista da Sociedade Brasileira de Medicina Tropical |
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21 |
container_issue |
3 |
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123 |
op_container_end_page |
129 |
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