Zika and dengue but not chikungunya are associated with Guillain-Barré syndrome in Mexico: A case-control study.
Background Zika, dengue and chikungunya viruses (ZIKV, CHIKV and DENV) are temporally associated with neurological diseases, such as Guillain-Barré syndrome (GBS). Because these three arboviruses coexist in Mexico, the frequency and severity of GBS could theoretically increase. This study aims to de...
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Online Access: | https://doi.org/10.1371/journal.pntd.0008032 https://doaj.org/article/3c06f30fe9e84c3692d43e24293502e9 |
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ftdoajarticles:oai:doaj.org/article:3c06f30fe9e84c3692d43e24293502e9 2023-05-15T15:15:30+02:00 Zika and dengue but not chikungunya are associated with Guillain-Barré syndrome in Mexico: A case-control study. Israel Grijalva Concepción Grajales-Muñiz César González-Bonilla Victor Hugo Borja-Aburto Martín Paredes-Cruz José Guerrero-Cantera Joaquín González-Ibarra Alfonso Vallejos-Parás Teresita Rojas-Mendoza Clara Esperanza Santacruz-Tinoco Porfirio Hernández-Bautista Lumumba Arriaga-Nieto Ma Guadalupe Garza-Sagástegui Ignacio Vargas-Ramos Ana Sepúlveda-Núñez Omar Israel Campos-Villarreal Roberto Corrales-Pérez Mallela Azuara-Castillo Elsa Sierra-González José Alfonso Meza-Medina Bernardo Martínez-Miguel Gabriela López-Becerril Jessica Ramos-Orozco Tomás Muñoz-Guerrero María Soledad Gutiérrez-Lozano Arlette Areli Cervantes-Ocampo 2020-12-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0008032 https://doaj.org/article/3c06f30fe9e84c3692d43e24293502e9 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0008032 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008032 https://doaj.org/article/3c06f30fe9e84c3692d43e24293502e9 PLoS Neglected Tropical Diseases, Vol 14, Iss 12, p e0008032 (2020) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2020 ftdoajarticles https://doi.org/10.1371/journal.pntd.0008032 2022-12-31T07:36:44Z Background Zika, dengue and chikungunya viruses (ZIKV, CHIKV and DENV) are temporally associated with neurological diseases, such as Guillain-Barré syndrome (GBS). Because these three arboviruses coexist in Mexico, the frequency and severity of GBS could theoretically increase. This study aims to determine the association between these arboviruses and GBS in a Mexican population and to establish the clinical characteristics of the patients, including the severity of the infection. A case-control study was conducted (2016/07/01-2018/06/30) in Instituto Mexicano del Seguro Social (Mexican Social Security Institute) hospitals, using serum and urine samples that were collected to determine exposure to ZIKV, DENV, CHIKV by RT-qPCR and serology (IgM). For the categorical variables analysis, Pearson's χ2 or Fisher exact tests were used, and the Mann-Whitney U test for continuous variables. To determine the association of GBS and viral infection diagnosis through laboratory and symptomatology before admission, we calculated the odds ratio (OR) and 95% confidence intervals (95%CI) using a 2x2 contingency table. A p-value ≤ 0.05 was considered as significant. Ninety-seven GBS cases and 184 controls were included. The association of GBS with ZIKV acute infection (OR, 8.04; 95% CI, 0.89-73.01, p = 0.047), as well as laboratory evidence of ZIKV infection (OR, 16.45; 95% CI, 2.03-133.56; p = 0.001) or Flavivirus (ZIKV and DENV) infection (OR, 6.35; 95% CI, 1.99-20.28; p = 0.001) was observed. Cases of GBS associated with ZIKV demonstrated a greater impairment of functional status and a higher percentage of mechanical ventilation. According to laboratory results, an association between ZIKV or ZIKV and DENV infection in patients with GBS was found. Cases of GBS associated with ZIKV exhibited a more severe clinical picture. Cases with co-infection were not found. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Barré ENVELOPE(-68.550,-68.550,-67.500,-67.500) PLOS Neglected Tropical Diseases 14 12 e0008032 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Israel Grijalva Concepción Grajales-Muñiz César González-Bonilla Victor Hugo Borja-Aburto Martín Paredes-Cruz José Guerrero-Cantera Joaquín González-Ibarra Alfonso Vallejos-Parás Teresita Rojas-Mendoza Clara Esperanza Santacruz-Tinoco Porfirio Hernández-Bautista Lumumba Arriaga-Nieto Ma Guadalupe Garza-Sagástegui Ignacio Vargas-Ramos Ana Sepúlveda-Núñez Omar Israel Campos-Villarreal Roberto Corrales-Pérez Mallela Azuara-Castillo Elsa Sierra-González José Alfonso Meza-Medina Bernardo Martínez-Miguel Gabriela López-Becerril Jessica Ramos-Orozco Tomás Muñoz-Guerrero María Soledad Gutiérrez-Lozano Arlette Areli Cervantes-Ocampo Zika and dengue but not chikungunya are associated with Guillain-Barré syndrome in Mexico: A case-control study. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Zika, dengue and chikungunya viruses (ZIKV, CHIKV and DENV) are temporally associated with neurological diseases, such as Guillain-Barré syndrome (GBS). Because these three arboviruses coexist in Mexico, the frequency and severity of GBS could theoretically increase. This study aims to determine the association between these arboviruses and GBS in a Mexican population and to establish the clinical characteristics of the patients, including the severity of the infection. A case-control study was conducted (2016/07/01-2018/06/30) in Instituto Mexicano del Seguro Social (Mexican Social Security Institute) hospitals, using serum and urine samples that were collected to determine exposure to ZIKV, DENV, CHIKV by RT-qPCR and serology (IgM). For the categorical variables analysis, Pearson's χ2 or Fisher exact tests were used, and the Mann-Whitney U test for continuous variables. To determine the association of GBS and viral infection diagnosis through laboratory and symptomatology before admission, we calculated the odds ratio (OR) and 95% confidence intervals (95%CI) using a 2x2 contingency table. A p-value ≤ 0.05 was considered as significant. Ninety-seven GBS cases and 184 controls were included. The association of GBS with ZIKV acute infection (OR, 8.04; 95% CI, 0.89-73.01, p = 0.047), as well as laboratory evidence of ZIKV infection (OR, 16.45; 95% CI, 2.03-133.56; p = 0.001) or Flavivirus (ZIKV and DENV) infection (OR, 6.35; 95% CI, 1.99-20.28; p = 0.001) was observed. Cases of GBS associated with ZIKV demonstrated a greater impairment of functional status and a higher percentage of mechanical ventilation. According to laboratory results, an association between ZIKV or ZIKV and DENV infection in patients with GBS was found. Cases of GBS associated with ZIKV exhibited a more severe clinical picture. Cases with co-infection were not found. |
format |
Article in Journal/Newspaper |
author |
Israel Grijalva Concepción Grajales-Muñiz César González-Bonilla Victor Hugo Borja-Aburto Martín Paredes-Cruz José Guerrero-Cantera Joaquín González-Ibarra Alfonso Vallejos-Parás Teresita Rojas-Mendoza Clara Esperanza Santacruz-Tinoco Porfirio Hernández-Bautista Lumumba Arriaga-Nieto Ma Guadalupe Garza-Sagástegui Ignacio Vargas-Ramos Ana Sepúlveda-Núñez Omar Israel Campos-Villarreal Roberto Corrales-Pérez Mallela Azuara-Castillo Elsa Sierra-González José Alfonso Meza-Medina Bernardo Martínez-Miguel Gabriela López-Becerril Jessica Ramos-Orozco Tomás Muñoz-Guerrero María Soledad Gutiérrez-Lozano Arlette Areli Cervantes-Ocampo |
author_facet |
Israel Grijalva Concepción Grajales-Muñiz César González-Bonilla Victor Hugo Borja-Aburto Martín Paredes-Cruz José Guerrero-Cantera Joaquín González-Ibarra Alfonso Vallejos-Parás Teresita Rojas-Mendoza Clara Esperanza Santacruz-Tinoco Porfirio Hernández-Bautista Lumumba Arriaga-Nieto Ma Guadalupe Garza-Sagástegui Ignacio Vargas-Ramos Ana Sepúlveda-Núñez Omar Israel Campos-Villarreal Roberto Corrales-Pérez Mallela Azuara-Castillo Elsa Sierra-González José Alfonso Meza-Medina Bernardo Martínez-Miguel Gabriela López-Becerril Jessica Ramos-Orozco Tomás Muñoz-Guerrero María Soledad Gutiérrez-Lozano Arlette Areli Cervantes-Ocampo |
author_sort |
Israel Grijalva |
title |
Zika and dengue but not chikungunya are associated with Guillain-Barré syndrome in Mexico: A case-control study. |
title_short |
Zika and dengue but not chikungunya are associated with Guillain-Barré syndrome in Mexico: A case-control study. |
title_full |
Zika and dengue but not chikungunya are associated with Guillain-Barré syndrome in Mexico: A case-control study. |
title_fullStr |
Zika and dengue but not chikungunya are associated with Guillain-Barré syndrome in Mexico: A case-control study. |
title_full_unstemmed |
Zika and dengue but not chikungunya are associated with Guillain-Barré syndrome in Mexico: A case-control study. |
title_sort |
zika and dengue but not chikungunya are associated with guillain-barré syndrome in mexico: a case-control study. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2020 |
url |
https://doi.org/10.1371/journal.pntd.0008032 https://doaj.org/article/3c06f30fe9e84c3692d43e24293502e9 |
long_lat |
ENVELOPE(-68.550,-68.550,-67.500,-67.500) |
geographic |
Arctic Barré |
geographic_facet |
Arctic Barré |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 14, Iss 12, p e0008032 (2020) |
op_relation |
https://doi.org/10.1371/journal.pntd.0008032 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008032 https://doaj.org/article/3c06f30fe9e84c3692d43e24293502e9 |
op_doi |
https://doi.org/10.1371/journal.pntd.0008032 |
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PLOS Neglected Tropical Diseases |
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e0008032 |
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