Single-Cell Transcriptome Profiling of Immune Cell Repertoire of the Atlantic Cod Which Naturally Lacks the Major Histocompatibility Class II System

• Published in: Frontiers in Immunology
• Main Authors: Naomi Croft Guslund, Monica Hongrø Solbakken, Marine S. O. Brieuc, Sissel Jentoft, Kjetill S. Jakobsen, Shuo-Wang Qiao
• Format: Article in Journal/Newspaper
• Language: English
• Published: Frontiers Media S.A. 2020
• Subjects: Atlantic cod (Gadus morhua); single-cell sequencing; GATA-3; immune system; gene marker; Immunologic diseases. Allergy; RC581-607; Gata; atlantic cod; Gadus morhua
• Online Access: https://doi.org/10.3389/fimmu.2020.559555; https://doaj.org/article/3bfaf14431304939a4a3652f9b77b580

The Atlantic cod’s unusual immune system, entirely lacking the Major Histocompatibility class II pathway, has prompted intriguing questions about what mechanisms are used to combat bacterial infections and how immunological memory is generated. By single-cell RNA sequencing we here report an in-dept...