Are pro-inflammatory markers associated with psychological distress in a cross-sectional study of healthy adolescents 15–17 years of age? The Fit Futures study
Abstract Background Inflammatory markers have been associated with depression and anxiety disorder in adolescents. Less is known about the association between inflammation and subclinical symptoms in the form of psychological distress. We investigated prevalence of psychological distress and examine...
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ftdoajarticles:oai:doaj.org/article:3bf1676714a24ac98d097c3bececf869 2023-05-15T17:43:36+02:00 Are pro-inflammatory markers associated with psychological distress in a cross-sectional study of healthy adolescents 15–17 years of age? The Fit Futures study Jonas Linkas Luai Awad Ahmed Gabor Csifcsak Nina Emaus Anne-Sofie Furberg Guri Grimnes Gunn Pettersen Kamilla Rognmo Tore Christoffersen 2022-03-01T00:00:00Z https://doi.org/10.1186/s40359-022-00779-8 https://doaj.org/article/3bf1676714a24ac98d097c3bececf869 EN eng BMC https://doi.org/10.1186/s40359-022-00779-8 https://doaj.org/toc/2050-7283 doi:10.1186/s40359-022-00779-8 2050-7283 https://doaj.org/article/3bf1676714a24ac98d097c3bececf869 BMC Psychology, Vol 10, Iss 1, Pp 1-13 (2022) Psychological distress Inflammatory markers Depressive symptoms Anxiety symptoms Adolescence Psychology BF1-990 article 2022 ftdoajarticles https://doi.org/10.1186/s40359-022-00779-8 2022-12-31T03:56:54Z Abstract Background Inflammatory markers have been associated with depression and anxiety disorder in adolescents. Less is known about the association between inflammation and subclinical symptoms in the form of psychological distress. We investigated prevalence of psychological distress and examined the associations between common pro-inflammatory markers and psychological distress in an adolescent population sample. Methods The study was based on data from 458 girls and 473 boys aged 15–17 years from the Fit Futures Study, a large-scale study on adolescent health, conducted in Northern Norway. Psychological distress was measured with the Hopkins Symptom Checklist (HSCL-10). Serum-levels of the following low-grade inflammatory markers were measured: C-reactive protein (CRP), interleukin 6 (IL-6), transforming growth factor-alpha (TGF-α), tumor necrosis factor alpha variant 1 (TRANCE) and tumor necrosis factor alpha variant 2 (TWEAK). Associations between quartiles of inflammatory markers and HSCL-10 were examined by logistic regression and adjusted for potential confounders in sex-stratified analyses. Results The proportion of psychological distress above cutoff were 26.9% and 10.8% among girls and boys, respectively. In both girls and boys, crude analysis showed positive associations between all inflammatory markers and HSCL-10, except for TWEAK and TRANCE in boys. However, none of these associations were statistically significant. Further, there were no significant findings in the adjusted analyses. Conclusion There was a higher prevalence of psychological distress in girls compared to boys. Pro-inflammatory markers were not significantly associated with psychological distress in data from healthy adolescents aged 15–17 years. Article in Journal/Newspaper Northern Norway Directory of Open Access Journals: DOAJ Articles Norway BMC Psychology 10 1 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Psychological distress Inflammatory markers Depressive symptoms Anxiety symptoms Adolescence Psychology BF1-990 |
spellingShingle |
Psychological distress Inflammatory markers Depressive symptoms Anxiety symptoms Adolescence Psychology BF1-990 Jonas Linkas Luai Awad Ahmed Gabor Csifcsak Nina Emaus Anne-Sofie Furberg Guri Grimnes Gunn Pettersen Kamilla Rognmo Tore Christoffersen Are pro-inflammatory markers associated with psychological distress in a cross-sectional study of healthy adolescents 15–17 years of age? The Fit Futures study |
topic_facet |
Psychological distress Inflammatory markers Depressive symptoms Anxiety symptoms Adolescence Psychology BF1-990 |
description |
Abstract Background Inflammatory markers have been associated with depression and anxiety disorder in adolescents. Less is known about the association between inflammation and subclinical symptoms in the form of psychological distress. We investigated prevalence of psychological distress and examined the associations between common pro-inflammatory markers and psychological distress in an adolescent population sample. Methods The study was based on data from 458 girls and 473 boys aged 15–17 years from the Fit Futures Study, a large-scale study on adolescent health, conducted in Northern Norway. Psychological distress was measured with the Hopkins Symptom Checklist (HSCL-10). Serum-levels of the following low-grade inflammatory markers were measured: C-reactive protein (CRP), interleukin 6 (IL-6), transforming growth factor-alpha (TGF-α), tumor necrosis factor alpha variant 1 (TRANCE) and tumor necrosis factor alpha variant 2 (TWEAK). Associations between quartiles of inflammatory markers and HSCL-10 were examined by logistic regression and adjusted for potential confounders in sex-stratified analyses. Results The proportion of psychological distress above cutoff were 26.9% and 10.8% among girls and boys, respectively. In both girls and boys, crude analysis showed positive associations between all inflammatory markers and HSCL-10, except for TWEAK and TRANCE in boys. However, none of these associations were statistically significant. Further, there were no significant findings in the adjusted analyses. Conclusion There was a higher prevalence of psychological distress in girls compared to boys. Pro-inflammatory markers were not significantly associated with psychological distress in data from healthy adolescents aged 15–17 years. |
format |
Article in Journal/Newspaper |
author |
Jonas Linkas Luai Awad Ahmed Gabor Csifcsak Nina Emaus Anne-Sofie Furberg Guri Grimnes Gunn Pettersen Kamilla Rognmo Tore Christoffersen |
author_facet |
Jonas Linkas Luai Awad Ahmed Gabor Csifcsak Nina Emaus Anne-Sofie Furberg Guri Grimnes Gunn Pettersen Kamilla Rognmo Tore Christoffersen |
author_sort |
Jonas Linkas |
title |
Are pro-inflammatory markers associated with psychological distress in a cross-sectional study of healthy adolescents 15–17 years of age? The Fit Futures study |
title_short |
Are pro-inflammatory markers associated with psychological distress in a cross-sectional study of healthy adolescents 15–17 years of age? The Fit Futures study |
title_full |
Are pro-inflammatory markers associated with psychological distress in a cross-sectional study of healthy adolescents 15–17 years of age? The Fit Futures study |
title_fullStr |
Are pro-inflammatory markers associated with psychological distress in a cross-sectional study of healthy adolescents 15–17 years of age? The Fit Futures study |
title_full_unstemmed |
Are pro-inflammatory markers associated with psychological distress in a cross-sectional study of healthy adolescents 15–17 years of age? The Fit Futures study |
title_sort |
are pro-inflammatory markers associated with psychological distress in a cross-sectional study of healthy adolescents 15–17 years of age? the fit futures study |
publisher |
BMC |
publishDate |
2022 |
url |
https://doi.org/10.1186/s40359-022-00779-8 https://doaj.org/article/3bf1676714a24ac98d097c3bececf869 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Northern Norway |
genre_facet |
Northern Norway |
op_source |
BMC Psychology, Vol 10, Iss 1, Pp 1-13 (2022) |
op_relation |
https://doi.org/10.1186/s40359-022-00779-8 https://doaj.org/toc/2050-7283 doi:10.1186/s40359-022-00779-8 2050-7283 https://doaj.org/article/3bf1676714a24ac98d097c3bececf869 |
op_doi |
https://doi.org/10.1186/s40359-022-00779-8 |
container_title |
BMC Psychology |
container_volume |
10 |
container_issue |
1 |
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1766145728892108800 |