Use of doxycycline for leptospirosis after high-risk exposure in São Paulo, Brazil
A clinical trial pilot study, double-blinded, randomized, and controlled with a placebo to assess the effectiveness of oral doxycycline (200 mg, single dose) in preventing leptospirosis after high exposure to potentially contamined water was performed in São Paulo, SP, Brazil. Confirmed cases were d...
Published in: | Revista do Instituto de Medicina Tropical de São Paulo |
---|---|
Main Authors: | , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Universidade de São Paulo (USP)
1998
|
Subjects: | |
Online Access: | https://doi.org/10.1590/S0036-46651998000100012 https://doaj.org/article/3b77991cfe3b4fdc96e2ab0182526316 |
id |
ftdoajarticles:oai:doaj.org/article:3b77991cfe3b4fdc96e2ab0182526316 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:3b77991cfe3b4fdc96e2ab0182526316 2024-09-09T19:27:56+00:00 Use of doxycycline for leptospirosis after high-risk exposure in São Paulo, Brazil Claudio R. GONSALEZ Jorge CASSEB Francisco G. V. MONTEIRO João B. PAULA-NETO Rufino B. FERNANDEZ Marcos V. SILVA Eide D. CAMARGO João M. P. MAIRINQUE Lucia C. TAVARES 1998-01-01T00:00:00Z https://doi.org/10.1590/S0036-46651998000100012 https://doaj.org/article/3b77991cfe3b4fdc96e2ab0182526316 EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651998000100012 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46651998000100012 0036-4665 1678-9946 https://doaj.org/article/3b77991cfe3b4fdc96e2ab0182526316 Revista do Instituto de Medicina Tropical de São Paulo, Vol 40, Iss 1, p 59 (1998) Leptospirosis control São Paulo Brazil Doxycycline Incidence Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 1998 ftdoajarticles https://doi.org/10.1590/S0036-46651998000100012 2024-08-05T17:49:31Z A clinical trial pilot study, double-blinded, randomized, and controlled with a placebo to assess the effectiveness of oral doxycycline (200 mg, single dose) in preventing leptospirosis after high exposure to potentially contamined water was performed in São Paulo, SP, Brazil. Confirmed cases were defined as those with leptospira IgM antibody and symptoms; asymptomatic cases were those presenting with IgM antibodies but no symptoms; and suspected cases were individuals with symptoms but no IgM antibody. Forty subjects were given doxycycline and 42 were given placebo. In the drug-treated group there were 2 confirmed cases, 11 asymptomatic cases, and 6 suspected cases. In the placebo group there were 5 confirmed, 6 symptomatic, and 5 suspected cases. Even though we found a protective association of doxycycline for confirmed leptospirosis cases (RR = 2.3) and seroconversion only (RR = 2.0), the association was not statistically significant because of the small number of individuals enrolled in this pilot study. We observed that the 22% of the volunteers already had IgM antibodies to leptospirosis at the first sampling. Finally, the attack rate to confirmed, asymptomatic, and suspected cases of Leptospirosis was 8.5%, 22%, and 13%, respectively, in this population. Um ensaio clínico, duplo-cego, ao acaso, e controlado com placebo para aferir a eficácia da doxiciclina (200 mg, dose única) em prevenir leptospirose após exposição de alto risco com água potencialmente contaminada foi realizado em São Paulo, SP, Brasil. Casos confirmados foram definidos como aqueles que apresentavam anticorpos IgM anti-Leptospira e sintomas; casos assintomáticos eram aqueles que apresentavam somente anticorpo IgM, casos suspeitos apresentavam sintomas, porém sem anticorpo IgM. 40 indivíduos tomaram doxaciclina e 42 tomaram placebo. No grupo tratado houve 2 casos confirmados, 11 assintomáticos e 6 casos suspeitos. No grupo placebo houve 5 casos confirmados, 6 assintomáticos e 5 casos suspeitos. Apesar de haver uma associação protetora da ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista do Instituto de Medicina Tropical de São Paulo 40 1 59 61 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Leptospirosis control São Paulo Brazil Doxycycline Incidence Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Leptospirosis control São Paulo Brazil Doxycycline Incidence Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Claudio R. GONSALEZ Jorge CASSEB Francisco G. V. MONTEIRO João B. PAULA-NETO Rufino B. FERNANDEZ Marcos V. SILVA Eide D. CAMARGO João M. P. MAIRINQUE Lucia C. TAVARES Use of doxycycline for leptospirosis after high-risk exposure in São Paulo, Brazil |
topic_facet |
Leptospirosis control São Paulo Brazil Doxycycline Incidence Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
A clinical trial pilot study, double-blinded, randomized, and controlled with a placebo to assess the effectiveness of oral doxycycline (200 mg, single dose) in preventing leptospirosis after high exposure to potentially contamined water was performed in São Paulo, SP, Brazil. Confirmed cases were defined as those with leptospira IgM antibody and symptoms; asymptomatic cases were those presenting with IgM antibodies but no symptoms; and suspected cases were individuals with symptoms but no IgM antibody. Forty subjects were given doxycycline and 42 were given placebo. In the drug-treated group there were 2 confirmed cases, 11 asymptomatic cases, and 6 suspected cases. In the placebo group there were 5 confirmed, 6 symptomatic, and 5 suspected cases. Even though we found a protective association of doxycycline for confirmed leptospirosis cases (RR = 2.3) and seroconversion only (RR = 2.0), the association was not statistically significant because of the small number of individuals enrolled in this pilot study. We observed that the 22% of the volunteers already had IgM antibodies to leptospirosis at the first sampling. Finally, the attack rate to confirmed, asymptomatic, and suspected cases of Leptospirosis was 8.5%, 22%, and 13%, respectively, in this population. Um ensaio clínico, duplo-cego, ao acaso, e controlado com placebo para aferir a eficácia da doxiciclina (200 mg, dose única) em prevenir leptospirose após exposição de alto risco com água potencialmente contaminada foi realizado em São Paulo, SP, Brasil. Casos confirmados foram definidos como aqueles que apresentavam anticorpos IgM anti-Leptospira e sintomas; casos assintomáticos eram aqueles que apresentavam somente anticorpo IgM, casos suspeitos apresentavam sintomas, porém sem anticorpo IgM. 40 indivíduos tomaram doxaciclina e 42 tomaram placebo. No grupo tratado houve 2 casos confirmados, 11 assintomáticos e 6 casos suspeitos. No grupo placebo houve 5 casos confirmados, 6 assintomáticos e 5 casos suspeitos. Apesar de haver uma associação protetora da ... |
format |
Article in Journal/Newspaper |
author |
Claudio R. GONSALEZ Jorge CASSEB Francisco G. V. MONTEIRO João B. PAULA-NETO Rufino B. FERNANDEZ Marcos V. SILVA Eide D. CAMARGO João M. P. MAIRINQUE Lucia C. TAVARES |
author_facet |
Claudio R. GONSALEZ Jorge CASSEB Francisco G. V. MONTEIRO João B. PAULA-NETO Rufino B. FERNANDEZ Marcos V. SILVA Eide D. CAMARGO João M. P. MAIRINQUE Lucia C. TAVARES |
author_sort |
Claudio R. GONSALEZ |
title |
Use of doxycycline for leptospirosis after high-risk exposure in São Paulo, Brazil |
title_short |
Use of doxycycline for leptospirosis after high-risk exposure in São Paulo, Brazil |
title_full |
Use of doxycycline for leptospirosis after high-risk exposure in São Paulo, Brazil |
title_fullStr |
Use of doxycycline for leptospirosis after high-risk exposure in São Paulo, Brazil |
title_full_unstemmed |
Use of doxycycline for leptospirosis after high-risk exposure in São Paulo, Brazil |
title_sort |
use of doxycycline for leptospirosis after high-risk exposure in são paulo, brazil |
publisher |
Universidade de São Paulo (USP) |
publishDate |
1998 |
url |
https://doi.org/10.1590/S0036-46651998000100012 https://doaj.org/article/3b77991cfe3b4fdc96e2ab0182526316 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 40, Iss 1, p 59 (1998) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651998000100012 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46651998000100012 0036-4665 1678-9946 https://doaj.org/article/3b77991cfe3b4fdc96e2ab0182526316 |
op_doi |
https://doi.org/10.1590/S0036-46651998000100012 |
container_title |
Revista do Instituto de Medicina Tropical de São Paulo |
container_volume |
40 |
container_issue |
1 |
container_start_page |
59 |
op_container_end_page |
61 |
_version_ |
1809897250129707008 |