Surveillance of the efficacy of artemether-lumefantrine and artesunate-amodiaquine for the treatment of uncomplicated Plasmodium falciparum among children under five in Togo, 2005-2009
Abstract Background Malaria remains a major public health problem in Togo. The national malaria control programme in Togo changed the anti-malarial treatment policy from monotherapy to artemisinin combination therapy in 2004. This study reports the results of therapeutic efficacy studies conducted o...
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ftdoajarticles:oai:doaj.org/article:3b53beb605b24ea1a1169a947f22a270 2023-05-15T15:11:27+02:00 Surveillance of the efficacy of artemether-lumefantrine and artesunate-amodiaquine for the treatment of uncomplicated Plasmodium falciparum among children under five in Togo, 2005-2009 Dorkenoo Monique A Barrette Amy Agbo Yao M Bogreau Hervé Kutoati Séenam Sodahlon Yao K Morgah Kodjo 2012-10-01T00:00:00Z https://doi.org/10.1186/1475-2875-11-338 https://doaj.org/article/3b53beb605b24ea1a1169a947f22a270 EN eng BMC http://www.malariajournal.com/content/11/1/338 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-11-338 1475-2875 https://doaj.org/article/3b53beb605b24ea1a1169a947f22a270 Malaria Journal, Vol 11, Iss 1, p 338 (2012) Malaria Plasmodium falciparum Therapeutic efficacy Artemisinin-based combination Togo Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2012 ftdoajarticles https://doi.org/10.1186/1475-2875-11-338 2022-12-31T08:45:40Z Abstract Background Malaria remains a major public health problem in Togo. The national malaria control programme in Togo changed the anti-malarial treatment policy from monotherapy to artemisinin combination therapy in 2004. This study reports the results of therapeutic efficacy studies conducted on artemether-lumefantrine and artesunate-amodiaquine for the treatment of uncomplicated Plasmodium falciparum malaria in Togo, between 2005 and 2009. Methods Children between 6 and 59 months of age, who were symptomatically infected with P. falciparum, were treated with either artemether-lumefantrine or artesunate-amodiaquine. The primary end-point was the 28-day cure rate, PCR-corrected for reinfection and recrudescence. Studies were conducted according to the standardized WHO protocol for the assessment of the efficacy of anti-malarial treatment. Differences between categorical data were compared using the chi-square test or the Fisher’s exact test where cell counts were ≤ 5. Differences in continuous data were compared using a t -test. Results A total of 16 studies were conducted in five sentinel sites, with 459, 505 and 332 children included in 2005, 2007 and 2009, respectively. The PCR-corrected 28-day cure rates using the per-protocol analysis were between 96%-100% for artemether-lumefantrine and 94%-100% for artesunate-amodiaquine. Conclusions Both formulations of artemisinin-based combination therapy were effective over time and no severe adverse events related to the treatment were reported during the studies. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 11 1 |
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Malaria Plasmodium falciparum Therapeutic efficacy Artemisinin-based combination Togo Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Malaria Plasmodium falciparum Therapeutic efficacy Artemisinin-based combination Togo Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Dorkenoo Monique A Barrette Amy Agbo Yao M Bogreau Hervé Kutoati Séenam Sodahlon Yao K Morgah Kodjo Surveillance of the efficacy of artemether-lumefantrine and artesunate-amodiaquine for the treatment of uncomplicated Plasmodium falciparum among children under five in Togo, 2005-2009 |
topic_facet |
Malaria Plasmodium falciparum Therapeutic efficacy Artemisinin-based combination Togo Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Malaria remains a major public health problem in Togo. The national malaria control programme in Togo changed the anti-malarial treatment policy from monotherapy to artemisinin combination therapy in 2004. This study reports the results of therapeutic efficacy studies conducted on artemether-lumefantrine and artesunate-amodiaquine for the treatment of uncomplicated Plasmodium falciparum malaria in Togo, between 2005 and 2009. Methods Children between 6 and 59 months of age, who were symptomatically infected with P. falciparum, were treated with either artemether-lumefantrine or artesunate-amodiaquine. The primary end-point was the 28-day cure rate, PCR-corrected for reinfection and recrudescence. Studies were conducted according to the standardized WHO protocol for the assessment of the efficacy of anti-malarial treatment. Differences between categorical data were compared using the chi-square test or the Fisher’s exact test where cell counts were ≤ 5. Differences in continuous data were compared using a t -test. Results A total of 16 studies were conducted in five sentinel sites, with 459, 505 and 332 children included in 2005, 2007 and 2009, respectively. The PCR-corrected 28-day cure rates using the per-protocol analysis were between 96%-100% for artemether-lumefantrine and 94%-100% for artesunate-amodiaquine. Conclusions Both formulations of artemisinin-based combination therapy were effective over time and no severe adverse events related to the treatment were reported during the studies. |
format |
Article in Journal/Newspaper |
author |
Dorkenoo Monique A Barrette Amy Agbo Yao M Bogreau Hervé Kutoati Séenam Sodahlon Yao K Morgah Kodjo |
author_facet |
Dorkenoo Monique A Barrette Amy Agbo Yao M Bogreau Hervé Kutoati Séenam Sodahlon Yao K Morgah Kodjo |
author_sort |
Dorkenoo Monique A |
title |
Surveillance of the efficacy of artemether-lumefantrine and artesunate-amodiaquine for the treatment of uncomplicated Plasmodium falciparum among children under five in Togo, 2005-2009 |
title_short |
Surveillance of the efficacy of artemether-lumefantrine and artesunate-amodiaquine for the treatment of uncomplicated Plasmodium falciparum among children under five in Togo, 2005-2009 |
title_full |
Surveillance of the efficacy of artemether-lumefantrine and artesunate-amodiaquine for the treatment of uncomplicated Plasmodium falciparum among children under five in Togo, 2005-2009 |
title_fullStr |
Surveillance of the efficacy of artemether-lumefantrine and artesunate-amodiaquine for the treatment of uncomplicated Plasmodium falciparum among children under five in Togo, 2005-2009 |
title_full_unstemmed |
Surveillance of the efficacy of artemether-lumefantrine and artesunate-amodiaquine for the treatment of uncomplicated Plasmodium falciparum among children under five in Togo, 2005-2009 |
title_sort |
surveillance of the efficacy of artemether-lumefantrine and artesunate-amodiaquine for the treatment of uncomplicated plasmodium falciparum among children under five in togo, 2005-2009 |
publisher |
BMC |
publishDate |
2012 |
url |
https://doi.org/10.1186/1475-2875-11-338 https://doaj.org/article/3b53beb605b24ea1a1169a947f22a270 |
geographic |
Arctic |
geographic_facet |
Arctic |
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Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 11, Iss 1, p 338 (2012) |
op_relation |
http://www.malariajournal.com/content/11/1/338 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-11-338 1475-2875 https://doaj.org/article/3b53beb605b24ea1a1169a947f22a270 |
op_doi |
https://doi.org/10.1186/1475-2875-11-338 |
container_title |
Malaria Journal |
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11 |
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1 |
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1766342299476819968 |