α:Non–α and Gγ:Aγ globin chain ratios in thalassemia intermedia patients treated with hydroxyurea

• Published in: Asian Pacific Journal of Tropical Biomedicine
• Main Authors: Abbas Najjari, Mohsen Asouri, Ladan Hosseini Gouhari, Haleh Akhavan Niaki, Amir Sasan Mozaffari Nejad, Seyyedeh Masoumeh Eslami, Hassan Abolghasemi, Ramin Ataee, Abdol Ali Ebrahimi, Masoumeh Rezaei Moshaei, Ali Asghar Ahmadi
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wolters Kluwer Medknow Publications 2014
• Subjects: Thalassemia intermedia; Globin chain; AUT-PAGE; Hydroxyurea; Hemoglobin; Arctic medicine. Tropical medicine; RC955-962; Biology (General); QH301-705.5; Arctic; Sickle
• Online Access: https://doi.org/10.12980/APJTB.4.2014C1161; https://doaj.org/article/3b48ae89f0834cddabaa88b28e45be4d

Objective: To elucidate the possible ways by which hydroxyurea molecules affect globin chain (α or β-like) synthesis. Methods: A total of 23 thalassemia intermedia patients (13 male and 10 female) aged between 5 and 26 years were treated for five months with 15 mg/(kg·day) of hydroxyurea. Hemoglobin...