A pilot study for control of hyperendemic cystic hydatid disease in China.
BACKGROUND: Cystic hydatid disease (CHD) is a global parasitic zoonosis caused by the dog tapeworm, Echinococcus granulosus. The disease is hyperendemic in western China because of poor economic development; limited community knowledge of CHD; widespread, small-scale household animal production; hom...
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ftdoajarticles:oai:doaj.org/article:3aed9858779c494e9593d0324c7376c3 2023-05-15T15:10:02+02:00 A pilot study for control of hyperendemic cystic hydatid disease in China. Wenbao Zhang Zhuangzhi Zhang Turhong Yimit Baoxin Shi Hasyeti Aili Gulnor Tulson Hong You Jun Li Darren J Gray Donald P McManus Jincheng Wang 2009-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0000534 https://doaj.org/article/3aed9858779c494e9593d0324c7376c3 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC2761615?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000534 https://doaj.org/article/3aed9858779c494e9593d0324c7376c3 PLoS Neglected Tropical Diseases, Vol 3, Iss 10, p e534 (2009) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2009 ftdoajarticles https://doi.org/10.1371/journal.pntd.0000534 2022-12-31T04:44:19Z BACKGROUND: Cystic hydatid disease (CHD) is a global parasitic zoonosis caused by the dog tapeworm, Echinococcus granulosus. The disease is hyperendemic in western China because of poor economic development; limited community knowledge of CHD; widespread, small-scale household animal production; home killing of livestock; and the feeding of dogs with uncooked offal. METHODOLOGY/PRINCIPAL FINDINGS: A control program focusing on monthly praziquantel (PZQ) treatment of all registered dogs and culling unwanted and stray dogs has been designed to control CHD in hyperendemic areas in China. A pilot field control project in two counties (Hutubi and Wensu) in Xinjiang, China showed that after 4 years of treatment, the prevalence of dogs with E. granulosus was reduced from 14.7% and 18.6%, respectively, to 0%, and this caused a 90%-100% decrease of CHD in sheep born after commencement of the control program. CONCLUSIONS/SIGNIFICANCE: The strategy aimed at preventing eggs being released from dogs into the environment by treating animals before adult tapeworms are patent can decrease E. granulosus transmission and considerably reduce hyperendemic CHD. Monthly treatment of dogs with PZQ and culling unwanted and stray dogs have been shown to be an efficient, highly cost-effective and practicable measure for implementation in rural communities. As a result, the Chinese Ministry of Health has launched an extensive CHD control program in 117 counties in western China using this control strategy. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 3 10 e534 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Wenbao Zhang Zhuangzhi Zhang Turhong Yimit Baoxin Shi Hasyeti Aili Gulnor Tulson Hong You Jun Li Darren J Gray Donald P McManus Jincheng Wang A pilot study for control of hyperendemic cystic hydatid disease in China. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND: Cystic hydatid disease (CHD) is a global parasitic zoonosis caused by the dog tapeworm, Echinococcus granulosus. The disease is hyperendemic in western China because of poor economic development; limited community knowledge of CHD; widespread, small-scale household animal production; home killing of livestock; and the feeding of dogs with uncooked offal. METHODOLOGY/PRINCIPAL FINDINGS: A control program focusing on monthly praziquantel (PZQ) treatment of all registered dogs and culling unwanted and stray dogs has been designed to control CHD in hyperendemic areas in China. A pilot field control project in two counties (Hutubi and Wensu) in Xinjiang, China showed that after 4 years of treatment, the prevalence of dogs with E. granulosus was reduced from 14.7% and 18.6%, respectively, to 0%, and this caused a 90%-100% decrease of CHD in sheep born after commencement of the control program. CONCLUSIONS/SIGNIFICANCE: The strategy aimed at preventing eggs being released from dogs into the environment by treating animals before adult tapeworms are patent can decrease E. granulosus transmission and considerably reduce hyperendemic CHD. Monthly treatment of dogs with PZQ and culling unwanted and stray dogs have been shown to be an efficient, highly cost-effective and practicable measure for implementation in rural communities. As a result, the Chinese Ministry of Health has launched an extensive CHD control program in 117 counties in western China using this control strategy. |
format |
Article in Journal/Newspaper |
author |
Wenbao Zhang Zhuangzhi Zhang Turhong Yimit Baoxin Shi Hasyeti Aili Gulnor Tulson Hong You Jun Li Darren J Gray Donald P McManus Jincheng Wang |
author_facet |
Wenbao Zhang Zhuangzhi Zhang Turhong Yimit Baoxin Shi Hasyeti Aili Gulnor Tulson Hong You Jun Li Darren J Gray Donald P McManus Jincheng Wang |
author_sort |
Wenbao Zhang |
title |
A pilot study for control of hyperendemic cystic hydatid disease in China. |
title_short |
A pilot study for control of hyperendemic cystic hydatid disease in China. |
title_full |
A pilot study for control of hyperendemic cystic hydatid disease in China. |
title_fullStr |
A pilot study for control of hyperendemic cystic hydatid disease in China. |
title_full_unstemmed |
A pilot study for control of hyperendemic cystic hydatid disease in China. |
title_sort |
pilot study for control of hyperendemic cystic hydatid disease in china. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2009 |
url |
https://doi.org/10.1371/journal.pntd.0000534 https://doaj.org/article/3aed9858779c494e9593d0324c7376c3 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 3, Iss 10, p e534 (2009) |
op_relation |
http://europepmc.org/articles/PMC2761615?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000534 https://doaj.org/article/3aed9858779c494e9593d0324c7376c3 |
op_doi |
https://doi.org/10.1371/journal.pntd.0000534 |
container_title |
PLoS Neglected Tropical Diseases |
container_volume |
3 |
container_issue |
10 |
container_start_page |
e534 |
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1766341102512635904 |