Epidemiological characterization of incident cases of Rickettsia infection in rural areas of Urabá region, Colombia.
INTRODUCTION:Most of the studies related to rickettsial infection in Colombia are cross-sectional because of the challenge in conducting prospective studies on infectious disease that may have a difficult diagnosis. Although cross-sectional studies are essential to detect people exposed to rickettsi...
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ftdoajarticles:oai:doaj.org/article:3ad6ab1bc65f4242b690e367bdca6805 2023-05-15T15:16:33+02:00 Epidemiological characterization of incident cases of Rickettsia infection in rural areas of Urabá region, Colombia. Juan Carlos Quintero Vélez Daniel Camilo Aguirre-Acevedo Juan David Rodas Margarita Arboleda Adriana Troyo Francisco Vega Aguilar Lisardo Osorio Quintero Carlos Rojas Arbeláez 2018-10-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0006911 https://doaj.org/article/3ad6ab1bc65f4242b690e367bdca6805 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC6242695?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006911 https://doaj.org/article/3ad6ab1bc65f4242b690e367bdca6805 PLoS Neglected Tropical Diseases, Vol 12, Iss 10, p e0006911 (2018) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2018 ftdoajarticles https://doi.org/10.1371/journal.pntd.0006911 2022-12-31T10:52:54Z INTRODUCTION:Most of the studies related to rickettsial infection in Colombia are cross-sectional because of the challenge in conducting prospective studies on infectious disease that may have a difficult diagnosis. Although cross-sectional studies are essential to detect people exposed to rickettsiae, they are not suited to demonstrate the recent circulation of this pathogen in areas at risk of transmission. OBJECTIVE:To characterize the epidemiology of incident cases of Spotted fever group (SFG) rickettsial infection in humans and equines from rural areas of Urabá region in Colombia where outbreaks of rickettsiae previously occurred. MATERIALS AND METHODS:A prospective study was conducted in the Alto de Mulatos and Las Changas in the Urabá region. Serum samples and socio-ecological information were collected from 597 people enrolled in 2015, and a second sample was collected from 273 people a year later. Indirect immune-fluorescence assays for detection of IgG antibody against rickettsiae were done using slides with Rickettsia rickettsii antigens. A titer ≥128 was considered positive. Incident cases were defined as (i) serological conversion of IgG titers from seronegative to seropositive or (ii) at least a four-fold increase in IgG end point titers in the second sample. RESULTS:The cumulative incidence of rickettsial infection was 6.23% (95%CI 3.67-9.78) in humans and 32.31% (21/65) of incident cases in equines. Incident cases were mostly females (82.35%), the median age of cases was 41.02 years (IQR 18.62-54.1), and 29.41% reported tick bites during the study period. Results from multivariate analysis showed that removal of ticks after working outdoors is a protective factor for rickettsial infection (RR 0.26, 95%CI 0.08-0.84) and that a higher incidence of infection occurred in people who reported fever in the last year (RR 4.26, 95%CI 1.15-9.31). CONCLUSIONS:These results showed recent circulation of SFG rickettsiae in areas where previous lethal outbreaks have been reported, supporting the implementation ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 12 10 e0006911 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
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English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Juan Carlos Quintero Vélez Daniel Camilo Aguirre-Acevedo Juan David Rodas Margarita Arboleda Adriana Troyo Francisco Vega Aguilar Lisardo Osorio Quintero Carlos Rojas Arbeláez Epidemiological characterization of incident cases of Rickettsia infection in rural areas of Urabá region, Colombia. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
INTRODUCTION:Most of the studies related to rickettsial infection in Colombia are cross-sectional because of the challenge in conducting prospective studies on infectious disease that may have a difficult diagnosis. Although cross-sectional studies are essential to detect people exposed to rickettsiae, they are not suited to demonstrate the recent circulation of this pathogen in areas at risk of transmission. OBJECTIVE:To characterize the epidemiology of incident cases of Spotted fever group (SFG) rickettsial infection in humans and equines from rural areas of Urabá region in Colombia where outbreaks of rickettsiae previously occurred. MATERIALS AND METHODS:A prospective study was conducted in the Alto de Mulatos and Las Changas in the Urabá region. Serum samples and socio-ecological information were collected from 597 people enrolled in 2015, and a second sample was collected from 273 people a year later. Indirect immune-fluorescence assays for detection of IgG antibody against rickettsiae were done using slides with Rickettsia rickettsii antigens. A titer ≥128 was considered positive. Incident cases were defined as (i) serological conversion of IgG titers from seronegative to seropositive or (ii) at least a four-fold increase in IgG end point titers in the second sample. RESULTS:The cumulative incidence of rickettsial infection was 6.23% (95%CI 3.67-9.78) in humans and 32.31% (21/65) of incident cases in equines. Incident cases were mostly females (82.35%), the median age of cases was 41.02 years (IQR 18.62-54.1), and 29.41% reported tick bites during the study period. Results from multivariate analysis showed that removal of ticks after working outdoors is a protective factor for rickettsial infection (RR 0.26, 95%CI 0.08-0.84) and that a higher incidence of infection occurred in people who reported fever in the last year (RR 4.26, 95%CI 1.15-9.31). CONCLUSIONS:These results showed recent circulation of SFG rickettsiae in areas where previous lethal outbreaks have been reported, supporting the implementation ... |
format |
Article in Journal/Newspaper |
author |
Juan Carlos Quintero Vélez Daniel Camilo Aguirre-Acevedo Juan David Rodas Margarita Arboleda Adriana Troyo Francisco Vega Aguilar Lisardo Osorio Quintero Carlos Rojas Arbeláez |
author_facet |
Juan Carlos Quintero Vélez Daniel Camilo Aguirre-Acevedo Juan David Rodas Margarita Arboleda Adriana Troyo Francisco Vega Aguilar Lisardo Osorio Quintero Carlos Rojas Arbeláez |
author_sort |
Juan Carlos Quintero Vélez |
title |
Epidemiological characterization of incident cases of Rickettsia infection in rural areas of Urabá region, Colombia. |
title_short |
Epidemiological characterization of incident cases of Rickettsia infection in rural areas of Urabá region, Colombia. |
title_full |
Epidemiological characterization of incident cases of Rickettsia infection in rural areas of Urabá region, Colombia. |
title_fullStr |
Epidemiological characterization of incident cases of Rickettsia infection in rural areas of Urabá region, Colombia. |
title_full_unstemmed |
Epidemiological characterization of incident cases of Rickettsia infection in rural areas of Urabá region, Colombia. |
title_sort |
epidemiological characterization of incident cases of rickettsia infection in rural areas of urabá region, colombia. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2018 |
url |
https://doi.org/10.1371/journal.pntd.0006911 https://doaj.org/article/3ad6ab1bc65f4242b690e367bdca6805 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 12, Iss 10, p e0006911 (2018) |
op_relation |
http://europepmc.org/articles/PMC6242695?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006911 https://doaj.org/article/3ad6ab1bc65f4242b690e367bdca6805 |
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https://doi.org/10.1371/journal.pntd.0006911 |
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PLOS Neglected Tropical Diseases |
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12 |
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10 |
container_start_page |
e0006911 |
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1766346845764714496 |