Vitamin D in a northern Canadian first nation population: dietary intake, serum concentrations and functional gene polymorphisms.
The wide spectrum of vitamin D activity has focused attention on its potential role in the elevated burden of disease in a northern Canadian First Nations (Dené) cohort. Vitamin D insufficiency, and gene polymorphisms in the vitamin D receptor (VDR) and vitamin D binding protein (VDBP) have been imp...
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ftdoajarticles:oai:doaj.org/article:3ac8d4535ec8481f8b841130f9de3640 2023-05-15T16:17:01+02:00 Vitamin D in a northern Canadian first nation population: dietary intake, serum concentrations and functional gene polymorphisms. Linda Larcombe Neeloffer Mookherjee Joyce Slater Caroline Slivinski Matthew Singer Chris Whaley Lizette Denechezhe Sara Matyas Emily Turner-Brannen Peter Nickerson Pamela Orr 2012-01-01T00:00:00Z https://doi.org/10.1371/journal.pone.0049872 https://doaj.org/article/3ac8d4535ec8481f8b841130f9de3640 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3503822?pdf=render https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0049872 https://doaj.org/article/3ac8d4535ec8481f8b841130f9de3640 PLoS ONE, Vol 7, Iss 11, p e49872 (2012) Medicine R Science Q article 2012 ftdoajarticles https://doi.org/10.1371/journal.pone.0049872 2022-12-31T00:01:21Z The wide spectrum of vitamin D activity has focused attention on its potential role in the elevated burden of disease in a northern Canadian First Nations (Dené) cohort. Vitamin D insufficiency, and gene polymorphisms in the vitamin D receptor (VDR) and vitamin D binding protein (VDBP) have been implicated in susceptibility to infectious and chronic diseases. The objectives of this study were to determine the contribution of vitamin D from food, and measure the serum concentrations of 25-hydroxyvitamin D(3) (25-OHD(3)) and VDBP in Dené participants. Single nucleotide polymorphisms (SNPs) associated with the dysregulation of the innate immune response were typed and counted. Potential correlations between the SNPs and serum concentrations of 25-OHD(3) and VDBP were evaluated. Venous blood was collected in summer and winter over a one-year period and analyzed for 25-OHD(3) and VDBP concentrations (N = 46). A questionnaire was administered to determine the amount of dietary vitamin D consumed. Sixty-one percent and 30% of the participants had 25-OHD(3) serum concentrations <75 nmol/L in the winter and summer respectively. Mean vitamin D binding protein concentrations were within the normal range in the winter but below normal in the summer. VDBP and VDR gene polymorphisms affect the bioavailability and regulation of 25-OHD(3). The Dené had a high frequency of the VDBP D432E-G allele (71%) and the Gc1 genotype (90%), associated with high concentrations of VDBP and a high binding affinity to 25-OHD(3). The Dené had a high frequency of VDR Fok1-f allele (82%), which has been associated with a down-regulated Th1 immune response. VDBP and VDR polymorphisms, and low winter 25-OHD(3) serum concentrations may be risk factors for infectious diseases and chronic conditions related to the dysregulation of the vitamin D pathway. Article in Journal/Newspaper First Nations Directory of Open Access Journals: DOAJ Articles PLoS ONE 7 11 e49872 |
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Medicine R Science Q Linda Larcombe Neeloffer Mookherjee Joyce Slater Caroline Slivinski Matthew Singer Chris Whaley Lizette Denechezhe Sara Matyas Emily Turner-Brannen Peter Nickerson Pamela Orr Vitamin D in a northern Canadian first nation population: dietary intake, serum concentrations and functional gene polymorphisms. |
topic_facet |
Medicine R Science Q |
description |
The wide spectrum of vitamin D activity has focused attention on its potential role in the elevated burden of disease in a northern Canadian First Nations (Dené) cohort. Vitamin D insufficiency, and gene polymorphisms in the vitamin D receptor (VDR) and vitamin D binding protein (VDBP) have been implicated in susceptibility to infectious and chronic diseases. The objectives of this study were to determine the contribution of vitamin D from food, and measure the serum concentrations of 25-hydroxyvitamin D(3) (25-OHD(3)) and VDBP in Dené participants. Single nucleotide polymorphisms (SNPs) associated with the dysregulation of the innate immune response were typed and counted. Potential correlations between the SNPs and serum concentrations of 25-OHD(3) and VDBP were evaluated. Venous blood was collected in summer and winter over a one-year period and analyzed for 25-OHD(3) and VDBP concentrations (N = 46). A questionnaire was administered to determine the amount of dietary vitamin D consumed. Sixty-one percent and 30% of the participants had 25-OHD(3) serum concentrations <75 nmol/L in the winter and summer respectively. Mean vitamin D binding protein concentrations were within the normal range in the winter but below normal in the summer. VDBP and VDR gene polymorphisms affect the bioavailability and regulation of 25-OHD(3). The Dené had a high frequency of the VDBP D432E-G allele (71%) and the Gc1 genotype (90%), associated with high concentrations of VDBP and a high binding affinity to 25-OHD(3). The Dené had a high frequency of VDR Fok1-f allele (82%), which has been associated with a down-regulated Th1 immune response. VDBP and VDR polymorphisms, and low winter 25-OHD(3) serum concentrations may be risk factors for infectious diseases and chronic conditions related to the dysregulation of the vitamin D pathway. |
format |
Article in Journal/Newspaper |
author |
Linda Larcombe Neeloffer Mookherjee Joyce Slater Caroline Slivinski Matthew Singer Chris Whaley Lizette Denechezhe Sara Matyas Emily Turner-Brannen Peter Nickerson Pamela Orr |
author_facet |
Linda Larcombe Neeloffer Mookherjee Joyce Slater Caroline Slivinski Matthew Singer Chris Whaley Lizette Denechezhe Sara Matyas Emily Turner-Brannen Peter Nickerson Pamela Orr |
author_sort |
Linda Larcombe |
title |
Vitamin D in a northern Canadian first nation population: dietary intake, serum concentrations and functional gene polymorphisms. |
title_short |
Vitamin D in a northern Canadian first nation population: dietary intake, serum concentrations and functional gene polymorphisms. |
title_full |
Vitamin D in a northern Canadian first nation population: dietary intake, serum concentrations and functional gene polymorphisms. |
title_fullStr |
Vitamin D in a northern Canadian first nation population: dietary intake, serum concentrations and functional gene polymorphisms. |
title_full_unstemmed |
Vitamin D in a northern Canadian first nation population: dietary intake, serum concentrations and functional gene polymorphisms. |
title_sort |
vitamin d in a northern canadian first nation population: dietary intake, serum concentrations and functional gene polymorphisms. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2012 |
url |
https://doi.org/10.1371/journal.pone.0049872 https://doaj.org/article/3ac8d4535ec8481f8b841130f9de3640 |
genre |
First Nations |
genre_facet |
First Nations |
op_source |
PLoS ONE, Vol 7, Iss 11, p e49872 (2012) |
op_relation |
http://europepmc.org/articles/PMC3503822?pdf=render https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0049872 https://doaj.org/article/3ac8d4535ec8481f8b841130f9de3640 |
op_doi |
https://doi.org/10.1371/journal.pone.0049872 |
container_title |
PLoS ONE |
container_volume |
7 |
container_issue |
11 |
container_start_page |
e49872 |
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