Genome-wide association study reveals multiple loci associated with primary tooth development during infancy.
Tooth development is a highly heritable process which relates to other growth and developmental processes, and which interacts with the development of the entire craniofacial complex. Abnormalities of tooth development are common, with tooth agenesis being the most common developmental anomaly in hu...
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ftdoajarticles:oai:doaj.org/article:3ab82573645d43d58948051fe2d36710 2023-05-15T17:42:29+02:00 Genome-wide association study reveals multiple loci associated with primary tooth development during infancy. Demetris Pillas Clive J Hoggart David M Evans Paul F O'Reilly Kirsi Sipilä Raija Lähdesmäki Iona Y Millwood Marika Kaakinen Gopalakrishnan Netuveli David Blane Pimphen Charoen Ulla Sovio Anneli Pouta Nelson Freimer Anna-Liisa Hartikainen Jaana Laitinen Sarianna Vaara Beate Glaser Peter Crawford Nicholas J Timpson Susan M Ring Guohong Deng Weihua Zhang Mark I McCarthy Panos Deloukas Leena Peltonen Paul Elliott Lachlan J M Coin George Davey Smith Marjo-Riitta Jarvelin 2010-02-01T00:00:00Z https://doi.org/10.1371/journal.pgen.1000856 https://doaj.org/article/3ab82573645d43d58948051fe2d36710 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC2829062?pdf=render https://doaj.org/toc/1553-7390 https://doaj.org/toc/1553-7404 1553-7390 1553-7404 doi:10.1371/journal.pgen.1000856 https://doaj.org/article/3ab82573645d43d58948051fe2d36710 PLoS Genetics, Vol 6, Iss 2, p e1000856 (2010) Genetics QH426-470 article 2010 ftdoajarticles https://doi.org/10.1371/journal.pgen.1000856 2022-12-31T05:10:06Z Tooth development is a highly heritable process which relates to other growth and developmental processes, and which interacts with the development of the entire craniofacial complex. Abnormalities of tooth development are common, with tooth agenesis being the most common developmental anomaly in humans. We performed a genome-wide association study of time to first tooth eruption and number of teeth at one year in 4,564 individuals from the 1966 Northern Finland Birth Cohort (NFBC1966) and 1,518 individuals from the Avon Longitudinal Study of Parents and Children (ALSPAC). We identified 5 loci at P<5x10(-8), and 5 with suggestive association (P<5x10(-6)). The loci included several genes with links to tooth and other organ development (KCNJ2, EDA, HOXB2, RAD51L1, IGF2BP1, HMGA2, MSRB3). Genes at four of the identified loci are implicated in the development of cancer. A variant within the HOXB gene cluster associated with occlusion defects requiring orthodontic treatment by age 31 years. Article in Journal/Newspaper Northern Finland Directory of Open Access Journals: DOAJ Articles PLoS Genetics 6 2 e1000856 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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language |
English |
topic |
Genetics QH426-470 |
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Genetics QH426-470 Demetris Pillas Clive J Hoggart David M Evans Paul F O'Reilly Kirsi Sipilä Raija Lähdesmäki Iona Y Millwood Marika Kaakinen Gopalakrishnan Netuveli David Blane Pimphen Charoen Ulla Sovio Anneli Pouta Nelson Freimer Anna-Liisa Hartikainen Jaana Laitinen Sarianna Vaara Beate Glaser Peter Crawford Nicholas J Timpson Susan M Ring Guohong Deng Weihua Zhang Mark I McCarthy Panos Deloukas Leena Peltonen Paul Elliott Lachlan J M Coin George Davey Smith Marjo-Riitta Jarvelin Genome-wide association study reveals multiple loci associated with primary tooth development during infancy. |
topic_facet |
Genetics QH426-470 |
description |
Tooth development is a highly heritable process which relates to other growth and developmental processes, and which interacts with the development of the entire craniofacial complex. Abnormalities of tooth development are common, with tooth agenesis being the most common developmental anomaly in humans. We performed a genome-wide association study of time to first tooth eruption and number of teeth at one year in 4,564 individuals from the 1966 Northern Finland Birth Cohort (NFBC1966) and 1,518 individuals from the Avon Longitudinal Study of Parents and Children (ALSPAC). We identified 5 loci at P<5x10(-8), and 5 with suggestive association (P<5x10(-6)). The loci included several genes with links to tooth and other organ development (KCNJ2, EDA, HOXB2, RAD51L1, IGF2BP1, HMGA2, MSRB3). Genes at four of the identified loci are implicated in the development of cancer. A variant within the HOXB gene cluster associated with occlusion defects requiring orthodontic treatment by age 31 years. |
format |
Article in Journal/Newspaper |
author |
Demetris Pillas Clive J Hoggart David M Evans Paul F O'Reilly Kirsi Sipilä Raija Lähdesmäki Iona Y Millwood Marika Kaakinen Gopalakrishnan Netuveli David Blane Pimphen Charoen Ulla Sovio Anneli Pouta Nelson Freimer Anna-Liisa Hartikainen Jaana Laitinen Sarianna Vaara Beate Glaser Peter Crawford Nicholas J Timpson Susan M Ring Guohong Deng Weihua Zhang Mark I McCarthy Panos Deloukas Leena Peltonen Paul Elliott Lachlan J M Coin George Davey Smith Marjo-Riitta Jarvelin |
author_facet |
Demetris Pillas Clive J Hoggart David M Evans Paul F O'Reilly Kirsi Sipilä Raija Lähdesmäki Iona Y Millwood Marika Kaakinen Gopalakrishnan Netuveli David Blane Pimphen Charoen Ulla Sovio Anneli Pouta Nelson Freimer Anna-Liisa Hartikainen Jaana Laitinen Sarianna Vaara Beate Glaser Peter Crawford Nicholas J Timpson Susan M Ring Guohong Deng Weihua Zhang Mark I McCarthy Panos Deloukas Leena Peltonen Paul Elliott Lachlan J M Coin George Davey Smith Marjo-Riitta Jarvelin |
author_sort |
Demetris Pillas |
title |
Genome-wide association study reveals multiple loci associated with primary tooth development during infancy. |
title_short |
Genome-wide association study reveals multiple loci associated with primary tooth development during infancy. |
title_full |
Genome-wide association study reveals multiple loci associated with primary tooth development during infancy. |
title_fullStr |
Genome-wide association study reveals multiple loci associated with primary tooth development during infancy. |
title_full_unstemmed |
Genome-wide association study reveals multiple loci associated with primary tooth development during infancy. |
title_sort |
genome-wide association study reveals multiple loci associated with primary tooth development during infancy. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2010 |
url |
https://doi.org/10.1371/journal.pgen.1000856 https://doaj.org/article/3ab82573645d43d58948051fe2d36710 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_source |
PLoS Genetics, Vol 6, Iss 2, p e1000856 (2010) |
op_relation |
http://europepmc.org/articles/PMC2829062?pdf=render https://doaj.org/toc/1553-7390 https://doaj.org/toc/1553-7404 1553-7390 1553-7404 doi:10.1371/journal.pgen.1000856 https://doaj.org/article/3ab82573645d43d58948051fe2d36710 |
op_doi |
https://doi.org/10.1371/journal.pgen.1000856 |
container_title |
PLoS Genetics |
container_volume |
6 |
container_issue |
2 |
container_start_page |
e1000856 |
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1766144360720629760 |