Systematic review of the status of pfhrp2 and pfhrp3 gene deletion, approaches and methods used for its estimation and reporting in Plasmodium falciparum populations in Africa: review of published studies 2010–2019
Abstract Background Malaria rapid diagnostic tests based on histidine-rich protein-2 have played a vital role in improving malaria case management and surveillance particularly in Africa, where Plasmodium falciparum is predominant. However, their usefulness has been threatened by the emergence of ge...
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ftdoajarticles:oai:doaj.org/article:3a8247d4e4054bb19a226fcb3f62f1de 2023-05-15T15:17:26+02:00 Systematic review of the status of pfhrp2 and pfhrp3 gene deletion, approaches and methods used for its estimation and reporting in Plasmodium falciparum populations in Africa: review of published studies 2010–2019 Bosco B. Agaba Adoke Yeka Sam Nsobya Emmanuel Arinaitwe Joaniter Nankabirwa Jimmy Opigo Paul Mbaka Chae Seung Lim Joan N. Kalyango Charles Karamagi Moses R. Kamya 2019-11-01T00:00:00Z https://doi.org/10.1186/s12936-019-2987-4 https://doaj.org/article/3a8247d4e4054bb19a226fcb3f62f1de EN eng BMC http://link.springer.com/article/10.1186/s12936-019-2987-4 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-019-2987-4 1475-2875 https://doaj.org/article/3a8247d4e4054bb19a226fcb3f62f1de Malaria Journal, Vol 18, Iss 1, Pp 1-10 (2019) Malaria rapid diagnostic tests Plasmodium falciparum Histidine rich protein 2 gene Systematic review Histidine rich protein 3 Gene deletion Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2019 ftdoajarticles https://doi.org/10.1186/s12936-019-2987-4 2022-12-31T03:46:40Z Abstract Background Malaria rapid diagnostic tests based on histidine-rich protein-2 have played a vital role in improving malaria case management and surveillance particularly in Africa, where Plasmodium falciparum is predominant. However, their usefulness has been threatened by the emergence of gene deletion on P. falciparum histidine rich protein 2 (pfhrp2) and P. falciparum histidine rich protein 3 (pfhrp3). Use of standard and recommended methods is key for accurate investigation, confirmation and reporting of pfhrp2 and pfhrp3 gene deletion. Methods A systematic review was conducted to assess the status, methods and approaches that have been used for investigation, confirmation and reporting of pfhrp2 and pfhrp3 gene deletion in Africa. An online search was done using PubMed and MEDLINE Google Scholar for all articles published in English on pfhrp2/3 gene deletion in Africa. Relevant articles that met the inclusion criteria were summarized and assessed based on the protocol recommended by the World Health Organization for confirmation and reporting of pfhrp2/3 gene deletion. Results The search identified a total of 18 articles out of which 14 (77.7%) fulfilled the criteria for inclusion and were retained for review. The articles were distributed across 12 countries where the pfhrp2 and pfhrp3 gene deletion studies were conducted and reported. The level of pfhrp2/3 gene deletion across selected studies in Africa ranged from the highest 62% to the lowest 0.4%. There was wide variation in methods and approaches including study designs, size and sampling and whether both pfhrp2 and pfhrp3 double deletions or pfhrp2 single deletion were investigated, with a wide variation in laboratory methods. Conclusion Based on the review, there is evidence of the presence of pfhrp2/3 gene-deleted P. falciparum parasites in Africa. The approaches and methods used for investigation, confirmation and reporting of pfhrp2/3 deleted parasites have varied between studies and across countries. Countries that are considering plans ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 18 1 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Malaria rapid diagnostic tests Plasmodium falciparum Histidine rich protein 2 gene Systematic review Histidine rich protein 3 Gene deletion Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Malaria rapid diagnostic tests Plasmodium falciparum Histidine rich protein 2 gene Systematic review Histidine rich protein 3 Gene deletion Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Bosco B. Agaba Adoke Yeka Sam Nsobya Emmanuel Arinaitwe Joaniter Nankabirwa Jimmy Opigo Paul Mbaka Chae Seung Lim Joan N. Kalyango Charles Karamagi Moses R. Kamya Systematic review of the status of pfhrp2 and pfhrp3 gene deletion, approaches and methods used for its estimation and reporting in Plasmodium falciparum populations in Africa: review of published studies 2010–2019 |
topic_facet |
Malaria rapid diagnostic tests Plasmodium falciparum Histidine rich protein 2 gene Systematic review Histidine rich protein 3 Gene deletion Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Malaria rapid diagnostic tests based on histidine-rich protein-2 have played a vital role in improving malaria case management and surveillance particularly in Africa, where Plasmodium falciparum is predominant. However, their usefulness has been threatened by the emergence of gene deletion on P. falciparum histidine rich protein 2 (pfhrp2) and P. falciparum histidine rich protein 3 (pfhrp3). Use of standard and recommended methods is key for accurate investigation, confirmation and reporting of pfhrp2 and pfhrp3 gene deletion. Methods A systematic review was conducted to assess the status, methods and approaches that have been used for investigation, confirmation and reporting of pfhrp2 and pfhrp3 gene deletion in Africa. An online search was done using PubMed and MEDLINE Google Scholar for all articles published in English on pfhrp2/3 gene deletion in Africa. Relevant articles that met the inclusion criteria were summarized and assessed based on the protocol recommended by the World Health Organization for confirmation and reporting of pfhrp2/3 gene deletion. Results The search identified a total of 18 articles out of which 14 (77.7%) fulfilled the criteria for inclusion and were retained for review. The articles were distributed across 12 countries where the pfhrp2 and pfhrp3 gene deletion studies were conducted and reported. The level of pfhrp2/3 gene deletion across selected studies in Africa ranged from the highest 62% to the lowest 0.4%. There was wide variation in methods and approaches including study designs, size and sampling and whether both pfhrp2 and pfhrp3 double deletions or pfhrp2 single deletion were investigated, with a wide variation in laboratory methods. Conclusion Based on the review, there is evidence of the presence of pfhrp2/3 gene-deleted P. falciparum parasites in Africa. The approaches and methods used for investigation, confirmation and reporting of pfhrp2/3 deleted parasites have varied between studies and across countries. Countries that are considering plans ... |
format |
Article in Journal/Newspaper |
author |
Bosco B. Agaba Adoke Yeka Sam Nsobya Emmanuel Arinaitwe Joaniter Nankabirwa Jimmy Opigo Paul Mbaka Chae Seung Lim Joan N. Kalyango Charles Karamagi Moses R. Kamya |
author_facet |
Bosco B. Agaba Adoke Yeka Sam Nsobya Emmanuel Arinaitwe Joaniter Nankabirwa Jimmy Opigo Paul Mbaka Chae Seung Lim Joan N. Kalyango Charles Karamagi Moses R. Kamya |
author_sort |
Bosco B. Agaba |
title |
Systematic review of the status of pfhrp2 and pfhrp3 gene deletion, approaches and methods used for its estimation and reporting in Plasmodium falciparum populations in Africa: review of published studies 2010–2019 |
title_short |
Systematic review of the status of pfhrp2 and pfhrp3 gene deletion, approaches and methods used for its estimation and reporting in Plasmodium falciparum populations in Africa: review of published studies 2010–2019 |
title_full |
Systematic review of the status of pfhrp2 and pfhrp3 gene deletion, approaches and methods used for its estimation and reporting in Plasmodium falciparum populations in Africa: review of published studies 2010–2019 |
title_fullStr |
Systematic review of the status of pfhrp2 and pfhrp3 gene deletion, approaches and methods used for its estimation and reporting in Plasmodium falciparum populations in Africa: review of published studies 2010–2019 |
title_full_unstemmed |
Systematic review of the status of pfhrp2 and pfhrp3 gene deletion, approaches and methods used for its estimation and reporting in Plasmodium falciparum populations in Africa: review of published studies 2010–2019 |
title_sort |
systematic review of the status of pfhrp2 and pfhrp3 gene deletion, approaches and methods used for its estimation and reporting in plasmodium falciparum populations in africa: review of published studies 2010–2019 |
publisher |
BMC |
publishDate |
2019 |
url |
https://doi.org/10.1186/s12936-019-2987-4 https://doaj.org/article/3a8247d4e4054bb19a226fcb3f62f1de |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 18, Iss 1, Pp 1-10 (2019) |
op_relation |
http://link.springer.com/article/10.1186/s12936-019-2987-4 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-019-2987-4 1475-2875 https://doaj.org/article/3a8247d4e4054bb19a226fcb3f62f1de |
op_doi |
https://doi.org/10.1186/s12936-019-2987-4 |
container_title |
Malaria Journal |
container_volume |
18 |
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1 |
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1766347675033141248 |