Effect of wide spectrum anti-helminthic drugs upon Schistosoma mansoni experimentally infected mice
Mebendazole, albendazole, levamisole and thiabendazole are well known as active drugs against several nematode species, and against cestodes as well, when the first two drugs are considered. None of the drugs have proven activity, however, against trematodes. We tested the effect of these drugs on t...
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ftdoajarticles:oai:doaj.org/article:3a56bfddf4f34864b598581d3a2c058e 2024-09-09T19:26:31+00:00 Effect of wide spectrum anti-helminthic drugs upon Schistosoma mansoni experimentally infected mice PANCERA Christiane Finardi ALVES Adriana Leal PASCHOALOTTI Maria Aparecida CHIEFFI Pedro Paulo 1997-01-01T00:00:00Z https://doaj.org/article/3a56bfddf4f34864b598581d3a2c058e EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651997000300007 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 0036-4665 1678-9946 https://doaj.org/article/3a56bfddf4f34864b598581d3a2c058e Revista do Instituto de Medicina Tropical de São Paulo, Vol 39, Iss 3, Pp 159-164 (1997) Schistosomiasis Schistosoma mansoni Mebendazole Albendazole Levamisole Thiabendazole Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 1997 ftdoajarticles 2024-08-05T17:49:31Z Mebendazole, albendazole, levamisole and thiabendazole are well known as active drugs against several nematode species, and against cestodes as well, when the first two drugs are considered. None of the drugs have proven activity, however, against trematodes. We tested the effect of these drugs on the fecal shedding of schistosome eggs and the recovering of adult schistosomes, after portal perfusion in Schistosoma mansoni experimentally infected mice. Balb/c mice infected with 80 S. mansoni cercariae were divided into three groups, each in turn subdivided into four other groups, for each tested drug. The first group was treated with each one of the studied drugs 25 days after S. mansoni infection; the second group was submitted to treatment with each one of the drugs 60 days after infection. Finally, the third group, considered as control, received no treatment. No effect upon fecal shedding of S. mansoni eggs and recovering of schistosomes after portal perfusion was observed when mice were treated with either mebendazole or albendazole. Mice treated with either levamisole or thiabendazole, on the other hand, showed a significant reduction in the recovering of adult schistosomes after portal perfusion, mainly when both drugs were given during the schistosomula evolution period, i.e., 25 days after cercariae penetration, probably due to unspecific immunomodulation Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic |
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Directory of Open Access Journals: DOAJ Articles |
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topic |
Schistosomiasis Schistosoma mansoni Mebendazole Albendazole Levamisole Thiabendazole Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Schistosomiasis Schistosoma mansoni Mebendazole Albendazole Levamisole Thiabendazole Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 PANCERA Christiane Finardi ALVES Adriana Leal PASCHOALOTTI Maria Aparecida CHIEFFI Pedro Paulo Effect of wide spectrum anti-helminthic drugs upon Schistosoma mansoni experimentally infected mice |
topic_facet |
Schistosomiasis Schistosoma mansoni Mebendazole Albendazole Levamisole Thiabendazole Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Mebendazole, albendazole, levamisole and thiabendazole are well known as active drugs against several nematode species, and against cestodes as well, when the first two drugs are considered. None of the drugs have proven activity, however, against trematodes. We tested the effect of these drugs on the fecal shedding of schistosome eggs and the recovering of adult schistosomes, after portal perfusion in Schistosoma mansoni experimentally infected mice. Balb/c mice infected with 80 S. mansoni cercariae were divided into three groups, each in turn subdivided into four other groups, for each tested drug. The first group was treated with each one of the studied drugs 25 days after S. mansoni infection; the second group was submitted to treatment with each one of the drugs 60 days after infection. Finally, the third group, considered as control, received no treatment. No effect upon fecal shedding of S. mansoni eggs and recovering of schistosomes after portal perfusion was observed when mice were treated with either mebendazole or albendazole. Mice treated with either levamisole or thiabendazole, on the other hand, showed a significant reduction in the recovering of adult schistosomes after portal perfusion, mainly when both drugs were given during the schistosomula evolution period, i.e., 25 days after cercariae penetration, probably due to unspecific immunomodulation |
format |
Article in Journal/Newspaper |
author |
PANCERA Christiane Finardi ALVES Adriana Leal PASCHOALOTTI Maria Aparecida CHIEFFI Pedro Paulo |
author_facet |
PANCERA Christiane Finardi ALVES Adriana Leal PASCHOALOTTI Maria Aparecida CHIEFFI Pedro Paulo |
author_sort |
PANCERA Christiane Finardi |
title |
Effect of wide spectrum anti-helminthic drugs upon Schistosoma mansoni experimentally infected mice |
title_short |
Effect of wide spectrum anti-helminthic drugs upon Schistosoma mansoni experimentally infected mice |
title_full |
Effect of wide spectrum anti-helminthic drugs upon Schistosoma mansoni experimentally infected mice |
title_fullStr |
Effect of wide spectrum anti-helminthic drugs upon Schistosoma mansoni experimentally infected mice |
title_full_unstemmed |
Effect of wide spectrum anti-helminthic drugs upon Schistosoma mansoni experimentally infected mice |
title_sort |
effect of wide spectrum anti-helminthic drugs upon schistosoma mansoni experimentally infected mice |
publisher |
Universidade de São Paulo (USP) |
publishDate |
1997 |
url |
https://doaj.org/article/3a56bfddf4f34864b598581d3a2c058e |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 39, Iss 3, Pp 159-164 (1997) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651997000300007 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 0036-4665 1678-9946 https://doaj.org/article/3a56bfddf4f34864b598581d3a2c058e |
_version_ |
1809896105422356480 |