Genetic variation and population structure in native Americans.
We examined genetic diversity and population structure in the American landmass using 678 autosomal microsatellite markers genotyped in 422 individuals representing 24 Native American populations sampled from North, Central, and South America. These data were analyzed jointly with similar data avail...
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ftdoajarticles:oai:doaj.org/article:3a511dd8a0ea4141b34f05722c6a5b4e 2023-05-15T15:44:14+02:00 Genetic variation and population structure in native Americans. Sijia Wang Cecil M Lewis Mattias Jakobsson Sohini Ramachandran Nicolas Ray Gabriel Bedoya Winston Rojas Maria V Parra Julio A Molina Carla Gallo Guido Mazzotti Giovanni Poletti Kim Hill Ana M Hurtado Damian Labuda William Klitz Ramiro Barrantes Maria Cátira Bortolini Francisco M Salzano Maria Luiza Petzl-Erler Luiza T Tsuneto Elena Llop Francisco Rothhammer Laurent Excoffier Marcus W Feldman Noah A Rosenberg Andrés Ruiz-Linares 2007-11-01T00:00:00Z https://doi.org/10.1371/journal.pgen.0030185 https://doaj.org/article/3a511dd8a0ea4141b34f05722c6a5b4e EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC2082466?pdf=render https://doaj.org/toc/1553-7390 https://doaj.org/toc/1553-7404 1553-7390 1553-7404 doi:10.1371/journal.pgen.0030185 https://doaj.org/article/3a511dd8a0ea4141b34f05722c6a5b4e PLoS Genetics, Vol 3, Iss 11, p e185 (2007) Genetics QH426-470 article 2007 ftdoajarticles https://doi.org/10.1371/journal.pgen.0030185 2022-12-31T02:36:45Z We examined genetic diversity and population structure in the American landmass using 678 autosomal microsatellite markers genotyped in 422 individuals representing 24 Native American populations sampled from North, Central, and South America. These data were analyzed jointly with similar data available in 54 other indigenous populations worldwide, including an additional five Native American groups. The Native American populations have lower genetic diversity and greater differentiation than populations from other continental regions. We observe gradients both of decreasing genetic diversity as a function of geographic distance from the Bering Strait and of decreasing genetic similarity to Siberians--signals of the southward dispersal of human populations from the northwestern tip of the Americas. We also observe evidence of: (1) a higher level of diversity and lower level of population structure in western South America compared to eastern South America, (2) a relative lack of differentiation between Mesoamerican and Andean populations, (3) a scenario in which coastal routes were easier for migrating peoples to traverse in comparison with inland routes, and (4) a partial agreement on a local scale between genetic similarity and the linguistic classification of populations. These findings offer new insights into the process of population dispersal and differentiation during the peopling of the Americas. Article in Journal/Newspaper Bering Strait Directory of Open Access Journals: DOAJ Articles Bering Strait PLoS Genetics 3 11 e185 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Genetics QH426-470 |
spellingShingle |
Genetics QH426-470 Sijia Wang Cecil M Lewis Mattias Jakobsson Sohini Ramachandran Nicolas Ray Gabriel Bedoya Winston Rojas Maria V Parra Julio A Molina Carla Gallo Guido Mazzotti Giovanni Poletti Kim Hill Ana M Hurtado Damian Labuda William Klitz Ramiro Barrantes Maria Cátira Bortolini Francisco M Salzano Maria Luiza Petzl-Erler Luiza T Tsuneto Elena Llop Francisco Rothhammer Laurent Excoffier Marcus W Feldman Noah A Rosenberg Andrés Ruiz-Linares Genetic variation and population structure in native Americans. |
topic_facet |
Genetics QH426-470 |
description |
We examined genetic diversity and population structure in the American landmass using 678 autosomal microsatellite markers genotyped in 422 individuals representing 24 Native American populations sampled from North, Central, and South America. These data were analyzed jointly with similar data available in 54 other indigenous populations worldwide, including an additional five Native American groups. The Native American populations have lower genetic diversity and greater differentiation than populations from other continental regions. We observe gradients both of decreasing genetic diversity as a function of geographic distance from the Bering Strait and of decreasing genetic similarity to Siberians--signals of the southward dispersal of human populations from the northwestern tip of the Americas. We also observe evidence of: (1) a higher level of diversity and lower level of population structure in western South America compared to eastern South America, (2) a relative lack of differentiation between Mesoamerican and Andean populations, (3) a scenario in which coastal routes were easier for migrating peoples to traverse in comparison with inland routes, and (4) a partial agreement on a local scale between genetic similarity and the linguistic classification of populations. These findings offer new insights into the process of population dispersal and differentiation during the peopling of the Americas. |
format |
Article in Journal/Newspaper |
author |
Sijia Wang Cecil M Lewis Mattias Jakobsson Sohini Ramachandran Nicolas Ray Gabriel Bedoya Winston Rojas Maria V Parra Julio A Molina Carla Gallo Guido Mazzotti Giovanni Poletti Kim Hill Ana M Hurtado Damian Labuda William Klitz Ramiro Barrantes Maria Cátira Bortolini Francisco M Salzano Maria Luiza Petzl-Erler Luiza T Tsuneto Elena Llop Francisco Rothhammer Laurent Excoffier Marcus W Feldman Noah A Rosenberg Andrés Ruiz-Linares |
author_facet |
Sijia Wang Cecil M Lewis Mattias Jakobsson Sohini Ramachandran Nicolas Ray Gabriel Bedoya Winston Rojas Maria V Parra Julio A Molina Carla Gallo Guido Mazzotti Giovanni Poletti Kim Hill Ana M Hurtado Damian Labuda William Klitz Ramiro Barrantes Maria Cátira Bortolini Francisco M Salzano Maria Luiza Petzl-Erler Luiza T Tsuneto Elena Llop Francisco Rothhammer Laurent Excoffier Marcus W Feldman Noah A Rosenberg Andrés Ruiz-Linares |
author_sort |
Sijia Wang |
title |
Genetic variation and population structure in native Americans. |
title_short |
Genetic variation and population structure in native Americans. |
title_full |
Genetic variation and population structure in native Americans. |
title_fullStr |
Genetic variation and population structure in native Americans. |
title_full_unstemmed |
Genetic variation and population structure in native Americans. |
title_sort |
genetic variation and population structure in native americans. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2007 |
url |
https://doi.org/10.1371/journal.pgen.0030185 https://doaj.org/article/3a511dd8a0ea4141b34f05722c6a5b4e |
geographic |
Bering Strait |
geographic_facet |
Bering Strait |
genre |
Bering Strait |
genre_facet |
Bering Strait |
op_source |
PLoS Genetics, Vol 3, Iss 11, p e185 (2007) |
op_relation |
http://europepmc.org/articles/PMC2082466?pdf=render https://doaj.org/toc/1553-7390 https://doaj.org/toc/1553-7404 1553-7390 1553-7404 doi:10.1371/journal.pgen.0030185 https://doaj.org/article/3a511dd8a0ea4141b34f05722c6a5b4e |
op_doi |
https://doi.org/10.1371/journal.pgen.0030185 |
container_title |
PLoS Genetics |
container_volume |
3 |
container_issue |
11 |
container_start_page |
e185 |
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1766378523185905664 |