Immunological Characteristics of Hyperreactive Malarial Splenomegaly Syndrome in Sudanese Patients
Hyperreactive Malarial Splenomegaly (HMS) is defined as a massive enlargement of the spleen resulting from abnormal immune responses after repeated exposure to the malaria parasites. This study was carried out in Khartoum, Sudan. Sudan is considered to be one of the countries where HMS is quite prev...
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ftdoajarticles:oai:doaj.org/article:3a48e3d99711429c83d12796bbf57ff8 2024-09-09T19:27:24+00:00 Immunological Characteristics of Hyperreactive Malarial Splenomegaly Syndrome in Sudanese Patients Tayseer Alkadarou Ahmed Musa Abedelgader Alkadarou Mohamed S. Mahfouz Marita Troye-Blomberg Ahmed M. Elhassan Ibrahim M. Elhassan 2013-01-01T00:00:00Z https://doi.org/10.1155/2013/961051 https://doaj.org/article/3a48e3d99711429c83d12796bbf57ff8 EN eng Wiley http://dx.doi.org/10.1155/2013/961051 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2013/961051 https://doaj.org/article/3a48e3d99711429c83d12796bbf57ff8 Journal of Tropical Medicine, Vol 2013 (2013) Arctic medicine. Tropical medicine RC955-962 article 2013 ftdoajarticles https://doi.org/10.1155/2013/961051 2024-08-05T17:48:40Z Hyperreactive Malarial Splenomegaly (HMS) is defined as a massive enlargement of the spleen resulting from abnormal immune responses after repeated exposure to the malaria parasites. This study was carried out in Khartoum, Sudan. Sudan is considered to be one of the countries where HMS is quite prevalent. The objective of the study was to determine the incidence of HMS in patients who reported to the Omdurman Tropical Diseases Hospital (OMTDH) in Sudan and to investigate the basic laboratory and immunological characteristics of this condition in these patients. A cross-sectional study was carried out in OMTDH, and all patients with enlarged spleens were included in the study. Thirty-one out of 335 (9.3%) patients were diagnosed as having the HMS condition using international criteria for HMS diagnosis. The mean serum immunoglobulin M (IgM) levels in HMS patient groups were 14.3±5 g/L, and this was significantly higher compared with geographically matched controls (P<0.001). Immunoglobulin G (IgG) C anticircumsporozoite (CSP) antibody levels were higher in the HMS patients although the difference was not statistically significant, when compared with a group of patients with mild malaria. In comparison with naïve European controls, both the HMS and the mild malaria groups had significantly higher antimalarial antibody levels P<0.001 and P<0.01, respectively. Plasma levels of interleukin 10 (IL10) and interferon gamma (IFNγ) were significantly increased in the HMS patients compared with the healthy control donors (P<0.05 and P<0.01) for IL10 and IFNγ, respectively. The findings of this study suggest that HMS is one of the significant causes of tropical splenomegaly in Sudan. HMS is associated with significant elevations of circulating IgM and antimalarial IgG antibodies as well as IL10 and IFNγ. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Tropical Medicine 2013 1 5 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Tayseer Alkadarou Ahmed Musa Abedelgader Alkadarou Mohamed S. Mahfouz Marita Troye-Blomberg Ahmed M. Elhassan Ibrahim M. Elhassan Immunological Characteristics of Hyperreactive Malarial Splenomegaly Syndrome in Sudanese Patients |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 |
description |
Hyperreactive Malarial Splenomegaly (HMS) is defined as a massive enlargement of the spleen resulting from abnormal immune responses after repeated exposure to the malaria parasites. This study was carried out in Khartoum, Sudan. Sudan is considered to be one of the countries where HMS is quite prevalent. The objective of the study was to determine the incidence of HMS in patients who reported to the Omdurman Tropical Diseases Hospital (OMTDH) in Sudan and to investigate the basic laboratory and immunological characteristics of this condition in these patients. A cross-sectional study was carried out in OMTDH, and all patients with enlarged spleens were included in the study. Thirty-one out of 335 (9.3%) patients were diagnosed as having the HMS condition using international criteria for HMS diagnosis. The mean serum immunoglobulin M (IgM) levels in HMS patient groups were 14.3±5 g/L, and this was significantly higher compared with geographically matched controls (P<0.001). Immunoglobulin G (IgG) C anticircumsporozoite (CSP) antibody levels were higher in the HMS patients although the difference was not statistically significant, when compared with a group of patients with mild malaria. In comparison with naïve European controls, both the HMS and the mild malaria groups had significantly higher antimalarial antibody levels P<0.001 and P<0.01, respectively. Plasma levels of interleukin 10 (IL10) and interferon gamma (IFNγ) were significantly increased in the HMS patients compared with the healthy control donors (P<0.05 and P<0.01) for IL10 and IFNγ, respectively. The findings of this study suggest that HMS is one of the significant causes of tropical splenomegaly in Sudan. HMS is associated with significant elevations of circulating IgM and antimalarial IgG antibodies as well as IL10 and IFNγ. |
format |
Article in Journal/Newspaper |
author |
Tayseer Alkadarou Ahmed Musa Abedelgader Alkadarou Mohamed S. Mahfouz Marita Troye-Blomberg Ahmed M. Elhassan Ibrahim M. Elhassan |
author_facet |
Tayseer Alkadarou Ahmed Musa Abedelgader Alkadarou Mohamed S. Mahfouz Marita Troye-Blomberg Ahmed M. Elhassan Ibrahim M. Elhassan |
author_sort |
Tayseer Alkadarou |
title |
Immunological Characteristics of Hyperreactive Malarial Splenomegaly Syndrome in Sudanese Patients |
title_short |
Immunological Characteristics of Hyperreactive Malarial Splenomegaly Syndrome in Sudanese Patients |
title_full |
Immunological Characteristics of Hyperreactive Malarial Splenomegaly Syndrome in Sudanese Patients |
title_fullStr |
Immunological Characteristics of Hyperreactive Malarial Splenomegaly Syndrome in Sudanese Patients |
title_full_unstemmed |
Immunological Characteristics of Hyperreactive Malarial Splenomegaly Syndrome in Sudanese Patients |
title_sort |
immunological characteristics of hyperreactive malarial splenomegaly syndrome in sudanese patients |
publisher |
Wiley |
publishDate |
2013 |
url |
https://doi.org/10.1155/2013/961051 https://doaj.org/article/3a48e3d99711429c83d12796bbf57ff8 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Tropical Medicine, Vol 2013 (2013) |
op_relation |
http://dx.doi.org/10.1155/2013/961051 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2013/961051 https://doaj.org/article/3a48e3d99711429c83d12796bbf57ff8 |
op_doi |
https://doi.org/10.1155/2013/961051 |
container_title |
Journal of Tropical Medicine |
container_volume |
2013 |
container_start_page |
1 |
op_container_end_page |
5 |
_version_ |
1809896828699672576 |